PUROMYCIN AMINONUCLEOSIDE
- Product Name
- PUROMYCIN AMINONUCLEOSIDE
- CAS No.
- 58-60-6
- Chemical Name
- PUROMYCIN AMINONUCLEOSIDE
- Synonyms
- ARDMA;Nsc3056;Aids000507;Aids-000507;aminonucleoside;3′-Amino-3′-deoxy-N6;3’-Amino-3’-deoxy-N6;aminonucleosidepuromycin;PuroMycin aMinonucleosid;PUROMYCIN AMINONUCLEOSIDE
- CBNumber
- CB5455647
- Molecular Formula
- C12H18N6O3
- Formula Weight
- 294.31
- MOL File
- 58-60-6.mol
PUROMYCIN AMINONUCLEOSIDE Property
- Melting point:
- 235℃ (Decomposition)
- Boiling point:
- 436.08°C (rough estimate)
- Density
- 1.2131 (rough estimate)
- refractive index
- 1.7000 (estimate)
- Flash point:
- >110°(230°F)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- H2O: 50 mg/mL, clear, slightly yellow
- form
- liquid
- pka
- 13.26±0.70(Predicted)
- color
- White
- Water Solubility
- Soluble in water at 50mg/ml. May require heating
- BRN
- 93902
- Stability:
- Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.
- InChIKey
- RYSMHWILUNYBFW-GRIPGOBMSA-N
- EPA Substance Registry System
- Adenosine, 3'-amino-3'-deoxy-N,N-dimethyl- (58-60-6)
N-Bromosuccinimide Price
- Product number
- P7130
- Product name
- Puromycin aminonucleoside
- Packaging
- 100mg
- Price
- $528.8
- Updated
- 2024/03/01
- Product number
- P7130
- Product name
- Puromycin aminonucleoside
- Packaging
- 1g
- Price
- $3920
- Updated
- 2024/03/01
- Product number
- J66301
- Product name
- Puromycin aminonucleoside, 98%
- Packaging
- 100mg
- Price
- $561
- Updated
- 2024/03/01
- Product number
- J66301
- Product name
- Puromycin aminonucleoside, 98%
- Packaging
- 500mg
- Price
- $2040
- Updated
- 2024/03/01
- Product number
- 15509
- Product name
- Puromycin Aminonucleoside
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $62
- Updated
- 2024/03/01
PUROMYCIN AMINONUCLEOSIDE Chemical Properties,Usage,Production
Description
Puromycin aminonucleoside (58-60-6) is the nucleoside moiety of puromycin (Cat.# 10-2100) which does not inhibit protein synthesis or induce apoptosis.1?It acts as a glomerular epithelial cell toxin2 and as such is a useful tool for producing animal models of nephropathy3,4, or puromycin aminonucleoside nephrosis (1-2.5 mg/100g rat body weight)5. Active in vivo.
Chemical Properties
White crystal
Uses
Puromycin aminonucleoside is a semi-synthetic derivative of puromycin which lacks the methoxyphenylalanyl moiety. Puromycin aminonucleoside is the key intermediate in the synthesis of semi-synthetic analogues of puromycin. It does not inhibit protein synthesis or induce apoptosis, but exhibits antitumour properties. Puromycin aminonucleoside-induced nephrosis is a well-described model of human idiopathic nephrotic syndrome, suppressing integrin expression in cultured glomerular epithelial cells.
Uses
Puromycin Aminonucleoside is an aminonucleoside portion of the antibiotic puromycin.
Definition
ChEBI: Puromycin derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring.
Safety Profile
An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx,.
References
1) Chow et al. (1995), Reevaluation of the role of de novo protein synthesis in rat thymocyte apoptosis; Exp. Cell Res., 216 149 2) Krishnamurti et al. (2001), Puromycin aminonucleoside suppresses integrin expression in cultured glomerular epithelial cells; J. Am. Soc. Nephrol., 12 758 3) Egashira et al. (2006), Tryptophan-niacin metabolism in rat with puromycin aminonucleoside-induced nephrosis; Int. J. Vitam. Nutr. Res., 76 28 4) Hagiwara et al. (2006), Mitochondrial dysfunction in focal segmental glomerulosclerosis of puromycin aminonucleoside nephrosis; Kidney Int., 69 1146 5) Lowenborg et al. (2000), Glomerular function and morphology in puromycin aminonucleoside nephropathy in rats; Nephrol. Dial. Transplant, 15 1547
PUROMYCIN AMINONUCLEOSIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from PUROMYCIN AMINONUCLEOSIDE manufacturers
- Product
- PUROMYCINAMINONUCLEOSIDE 58-60-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- KG/T
- Release date
- 2019-12-17