Description Uses Safety References
ChemicalBook > CAS DataBase List > Methylisothiazolinone

Methylisothiazolinone

Description Uses Safety References
Product Name
Methylisothiazolinone
CAS No.
2682-20-4
Chemical Name
Methylisothiazolinone
Synonyms
MIT50%;MIT-20;KATHONCG;Skycide 100;MIT, 100ppm;Isothiazolone;2-Methyl-4-iso;Isothiazolone 14%;METHYLISOTHIAZOLIN;METHYLISOTHIAZOLINE
CBNumber
CB0193926
Molecular Formula
C4H5NOS
Formula Weight
115.15
MOL File
2682-20-4.mol
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Methylisothiazolinone Property

Melting point:
254-256 °C(lit.)
Boiling point:
bp0.03 93°
Density 
1.25 (14% aq.)
vapor pressure 
<0.1 mm Hg ( 25 °C)
storage temp. 
2-8°C
pka
-2.03±0.20(Predicted)
form 
neat
BRN 
606203
InChIKey
BEGLCMHJXHIJLR-UHFFFAOYSA-N
CAS DataBase Reference
2682-20-4(CAS DataBase Reference)
NIST Chemistry Reference
3(2H)-isothiazolone, 2-methyl-(2682-20-4)
EPA Substance Registry System
2-Methyl-3(2H)-isothiazolone (2682-20-4)
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Safety

Hazard Codes 
N,C,T
Risk Statements 
50/53-50-43-34-20/21/22-37-23-22
Safety Statements 
60-61-36/37/39-26-24-45
RIDADR 
UN 3077 9/PG 3
WGK Germany 
2
RTECS 
FE1250000
HazardClass 
8
PackingGroup 
III
HS Code 
29349990
Hazardous Substances Data
2682-20-4(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H331Toxic if inhaled

H335May cause respiratory irritation

H400Very toxic to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P310Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
725765
Product name
2-Methyl-4-isothiazolin-3-one
Purity
95%
Packaging
5g
Price
$81.7
Updated
2021/03/22
Sigma-Aldrich
Product number
725765
Product name
2-Methyl-4-isothiazolin-3-one
Purity
95%
Packaging
25g
Price
$323
Updated
2021/03/22
Sigma-Aldrich
Product number
73569
Product name
2-Methyl-4-isothiazolin-3-one
Purity
analytical standard
Packaging
1g
Price
$101
Updated
2021/03/22
Cayman Chemical
Product number
28136
Product name
Methylisothiazolinone
Packaging
10mL
Price
$125
Updated
2021/03/22
Cayman Chemical
Product number
28136
Product name
Methylisothiazolinone
Packaging
25mL
Price
$219
Updated
2021/03/22
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Methylisothiazolinone Chemical Properties,Usage,Production

Description

Methylisothiazolinone (also called 2-methyl-4-isothiazolin-3-one), is a powerful synthetic biocide and preservative within the group of  isothiazolinones.
Methylisothiazolinone is used to control slime-forming bacteria, fungi, and algae in pulp/paper mills, cooling water systems, oil field operations, industrial process waters, and air washer systems. And it is incorporated into adhesives, coatings, fuels, metal working fluids, resin emulsions, paints, and various other specialty industrial products as a preservative. It is also used to control the growth of mold, mildew, and sapstain on wood products. It is generally recommended for use only in rinse-off and leave-on cosmetic products (maximum concentration of 100 ppm) as preservative such as shampoo, conditioner, hair color, body wash, lotion, sunscreen, mascara, shaving cream, baby lotion, baby shampoo, hairspray, makeup remover, liquid soaps, and detergents. Nevertheless, methylisothiazolinone is allergenic. It is reported that methylisothiazolinone in rinse-off products causes allergic contact dermatitis.

Uses

Methylisothiazolinone, or MIT as it is sometimes known, is a preservative used in cosmetics and beauty products. It is a powerful biocide, or “chemical substance capable of killing living organisms, usually in a selective way.”Biocides are a general term that includes antimicrobial, germicide, antibiotic, and antifungal. Ultimately, Methylisothiazolinone is used to prevent a wide variety of bacteria and fungi from growing in cosmetics and beauty products, most often in shampoo. It is only approved for use in rinse-off formulas and at low concentrations.

Safety

Methylisothiazolinone (MIT) is a heterocyclic organic compound used as a preservative in cosmetics and personal care products in concentrations up to 0.01%. MIT is a colorless, clear liquid with a mild odor that is completely soluble in water; mostly soluble in acetonitrile, methanol, and hexane; and slightly soluble in xylene. Consistent with its solubility, dermal penetration is low. The Cosmetic Ingredient Review Expert Panel noted the in vitro evidence of neurotoxicity but concluded that the absence of any neurotoxicity findings in the many in vivo studies, including subchronic, chronic, and reproductive and developmental animal studies, suggests that MIT would not be neurotoxic as used in cosmetics. Although recognizing that MIT was a sensitizer in both animal and human studies, the panel concluded that there is a threshold dose response and that cosmetic products formulated to contain concentrations of MIT at 100 ppm (0.0 1%) or less would not be expected to pose a sensitization risk. Accordingly, MIT may be safely used as a preservative in cosmetics up to that concentration.

References

[1] http://www.safecosmetics.org/get-the-facts/chemicals-of-concern/methylisothiazolinone/
[2] K. Yazar, M. D. Lundov, A. Faurschou, M. Matura, A. Boman, J. D. Johansen, C. Lidén (2015) Methylisothiazolinone in rinse-off products causes allergic contact dermatitis: a repeated open-application study, 173, 115-122
[3] https://www3.epa.gov/pesticides/chem_search/reg_actions/reregistration/fs_G-58_1-Oct-98.pdf

Description

MI is contained in Kathon CG, MCI/MI and Euxyl K100. It can cause severe irritant dermatitis, as with Euxyl K100 incorporated in a cleansing cream used by an engine man.

Chemical Properties

Yellow Low melting Solid

Uses

2-Methyl-4-isothiazolin-3-one is a isothiazolinone based biocide and preservative used in personal care products. 2-Methyl-4-isothiazolin-3-one is also used for controlling microbial growth in water-c ontaining solution.

Uses

A potent biocide useful for controlling microbial growth

Uses

methylisothiazolinone is a preservative.

Definition

ChEBI: A 1,2-thazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom. It is a powerful biocide and preservative and is the minor active ingredient in the commercial product KathonTM.

Contact allergens

MI is generally associated with MCI, in Kathon? CG, MCI/MI, and Euxyl? K 100. This preservative is currently used in water-based products such as cosmetics, paints, and glues. Skin contact with concentrated solution can cause severe irritant dermatitis.

Methylisothiazolinone Preparation Products And Raw materials

Raw materials

Preparation Products

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Methylisothiazolinone Suppliers

Wuhan Hongde Yuexin Pharmatech Co.,Ltd
Tel
027-83855396-
Fax
027-83855396
Email
whhdyxchem@sina.com
Country
China
ProdList
749
Advantage
58
ShangHai Anpel Co, Ltd.
Tel
021-54890099
Email
shanpel@anpel.com.cn
Country
CHINA
ProdList
1584
Advantage
58
Wuhan ShuEr Biology Technology Co.,Ltd
Tel
Fax
QQ 1799696397
Email
1799696397@qq.com
Country
China
ProdList
2247
Advantage
58
Foshan Lanfeng additives Co., Ltd
Tel
0757-86600570
Fax
0757-86600190
Email
2814782833@qq.com
Country
CHINA
ProdList
34
Advantage
58
Hangzhou Jingyou Chemical Co., Ltd.
Tel
571-28350142- ;
Fax
0571-87219532
Email
sales@jingyouchem.com;joy@jingyouchem.com
Country
China
ProdList
123
Advantage
58
Tianjin Zhongxin Chemtech Co., Ltd.
Tel
022-66880623;022-89880623
Fax
86(0)22-66880086
Email
sales@tjzxchem.com;sales@tjzxchem.com
Country
China
ProdList
617
Advantage
60
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2346
Advantage
56
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
9917
Advantage
62
Nanjing Chemlin Chemical Co., Ltd
Tel
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
20007
Advantage
64
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View Lastest Price from Methylisothiazolinone manufacturers

Hebei Crovell Biotech Co Ltd
Product
Methylisothiazolinone (MIT) 2682-20-4
Price
US $9.10/KG
Min. Order
1KG
Purity
99.%
Supply Ability
10 ton
Release date
2021-08-13
Shanghai Yunao International Trade Co., Ltd
Product
2-Methyl-4-Isothiazolin-3-one 2682-20-4
Price
US $20.00/ASSAYS
Min. Order
1ASSAYS
Purity
99%
Supply Ability
100ton
Release date
2021-11-30
Hebei Zhanyao Biotechnology Co. Ltd
Product
Methylisothiazolinone 2682-20-4
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2021-11-25

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