2-Amino-4,6-dichloropyrimidine
- Product Name
- 2-Amino-4,6-dichloropyrimidine
- CAS No.
- 56-05-3
- Chemical Name
- 2-Amino-4,6-dichloropyrimidine
- Synonyms
- 4,6-DICHLOROPYRIMIDIN-2-AMINE;ADCP;2-PYRIMIDINAMINE, 4,6-DICHLORO-;py11;AKOS 90013;oropyrimidine;2-Amino-4,6-dichL;TIMTEC-BB SBB003919;6-dichloropyriMidine;LABOTEST-BB LT00080771
- CBNumber
- CB3128097
- Molecular Formula
- C4H3Cl2N3
- Formula Weight
- 163.99
- MOL File
- 56-05-3.mol
2-Amino-4,6-dichloropyrimidine Property
- Melting point:
- 219-222 °C (lit.)
- Boiling point:
- 219-222°C
- Density
- 1.6662 (rough estimate)
- refractive index
- 1.6300 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 0.14±0.10(Predicted)
- form
- Liquid
- color
- Clear colorless to light yellow
- Water Solubility
- Insoluble in water, soluble in acetone, two monomer (VCM) and thermal toluene.
- BRN
- 118454
- InChI
- InChI=1S/C4H3Cl2N3/c5-2-1-3(6)9-4(7)8-2/h1H,(H2,7,8,9)
- InChIKey
- JPZOAVGMSDSWSW-UHFFFAOYSA-N
- SMILES
- C1(N)=NC(Cl)=CC(Cl)=N1
- CAS DataBase Reference
- 56-05-3(CAS DataBase Reference)
- EPA Substance Registry System
- 2-Pyrimidinamine, 4,6-dichloro- (56-05-3)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-24/25
- WGK Germany
- 3
- RTECS
- UV6260485
- F
- 10
- TSCA
- TSCA listed
- HazardClass
- IRRITANT
- HS Code
- 29335995
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A48601
- Product name
- 2-Amino-4,6-dichloropyrimidine
- Purity
- 98%
- Packaging
- 10G
- Price
- $121
- Updated
- 2025/07/31
- Product number
- A48601
- Product name
- 2-Amino-4,6-dichloropyrimidine
- Purity
- 98%
- Packaging
- 100G
- Price
- $287
- Updated
- 2025/07/31
- Product number
- A1110
- Product name
- 2-Amino-4,6-dichloropyrimidine
- Purity
- >98.0%(N)
- Packaging
- 25g
- Price
- $86
- Updated
- 2025/07/31
- Product number
- A1456
- Product name
- 2-Amino-4,6-dichloropyrimidine
- Purity
- >95.0%(N)
- Packaging
- 25g
- Price
- $89
- Updated
- 2023/06/20
- Product number
- A577135
- Product name
- 2-Amino-4,5-dichloropyrimidine
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
2-Amino-4,6-dichloropyrimidine Chemical Properties,Usage,Production
Chemical Properties
LIGHT BROWN CRYSTALLINE POWDER
Uses
Microwave-assisted synthesis of pyrazolo [3, 4-d] pyrimidines from 2-amino-4, 6-dichloropyrimidine-5-carbaldehyde is under solvent-free conditions. A series of 6-alkynyl-2,4-diaminopyrimidine derivatives bearing various substituents at alkynyl moiety was prepared by the Sonogashira cross-coupling reaction of 2,4-diamino-6-iodopyrimidine using Pd(PPh3)2Cl2 as catalyst.
Synthesis
56-09-7
56-05-3
The general procedure for the synthesis of 2-amino-4,6-dichloropyrimidine from 2-amino-4,6-dihydroxypyrimidine is as follows: in a four-necked flask equipped with a reflux condenser, 510 g of 2-amino-4,6-dihydroxypyrimidine (98% purity, 4 mol) and 1428 g of phosphorus triclosan (99% purity) were added, heated and stirred. 810 g of triethylamine (99% purity) was slowly added dropwise at 40 to 45 °C through a constant pressure dropping funnel. After the dropwise addition, the reaction temperature was raised to 85 to 90 °C and maintained at this temperature for 2 hours. The progress of the reaction was monitored by high performance liquid chromatography (HPLC) and the reaction was considered complete when the amount of 2-amino-4,6-dihydroxypyrimidine was less than 1%. Subsequently, 3000 g of toluene was added to the reaction mixture, cooled to 0-10°C, and 3000 g of ice-water mixture was added for low temperature hydrolysis. The mixture was then warmed to room temperature and left to stratify. The aqueous layer was extracted twice with 400 g of toluene, and the organic phases were combined and washed sequentially with aqueous sodium carbonate and water until neutral. The organic phase was concentrated and 1800 g of toluene was recovered to give 2668 g of highly concentrated toluene solution. The product was analyzed by HPLC, the purity was 96.8%, the content was 22.58% (external standard method), and the yield of crude product was 92%.
References
[1] Patent: CN108395409, 2018, A. Location in patent: Paragraph 0046-0047; 0050
[2] Organic Letters, 2009, vol. 11, # 1, p. 61 - 64
[3] Chemical Communications, 2017, vol. 53, # 18, p. 2689 - 2692
[4] Organic and Biomolecular Chemistry, 2017, vol. 15, # 47, p. 10087 - 10094
[5] Tetrahedron Letters, 2015, vol. 56, # 10, p. 1179 - 1182
2-Amino-4,6-dichloropyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Amino-4,6-dichloropyrimidine manufacturers
- Product
- 2-Amino-4,6-dichloropyrimidine 56-05-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 5000kg
- Purity
- 0.99
- Supply Ability
- 50 tons
- Release date
- 2025-03-11
- Product
- 2-Amino-4,6-dichloropyrimidine 56-05-3
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2025-03-14
- Product
- 2-Amino-4,6-dichloropyrimidine 56-05-3
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-13