ChemicalBook > CAS DataBase List > 6-Chloropyrimidin-4(3H)-one

6-Chloropyrimidin-4(3H)-one

Product Name
6-Chloropyrimidin-4(3H)-one
CAS No.
4765-77-9
Chemical Name
6-Chloropyrimidin-4(3H)-one
Synonyms
NSC 618279;6-Chlorpyrimidin-4-ol;6-Chloro-4-pyrimidinol;6-CHLOROPYRIMIDIN-4-OL;4-Chloropyrimidin-6-one;6-chloropyriMidine-4-ol;6-CHLOROPYRIMIDIN-4(3H)-ONE;6-Chloro-4(1H)-Pyrimidinone;6-chloro-4(3H)-Pyrimidinone;6-chloropyrimidin-4(1H)-one
CBNumber
CB8853660
Molecular Formula
C4H3ClN2O
Formula Weight
130.53
MOL File
4765-77-9.mol
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6-Chloropyrimidin-4(3H)-one Property

Melting point:
194 °C
Boiling point:
199.4±50.0 °C(Predicted)
Density 
1.55±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO, Water
form 
Solid
pka
6.92±0.40(Predicted)
color 
Off-White to Pale Yellowish
CAS DataBase Reference
4765-77-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-41-37/38-22
Safety Statements 
22-26-36/37/39-39
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C2368
Product name
4-Chloro-6-hydroxypyrimidine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$34
Updated
2025/07/31
TCI Chemical
Product number
C2368
Product name
4-Chloro-6-hydroxypyrimidine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$132
Updated
2025/07/31
TRC
Product number
C366670
Product name
4-Chloro-6-hydroxypyrimidine
Packaging
5g
Price
$65
Updated
2021/12/16
Usbiological
Product number
C5010-37
Product name
4-Chloro-6-hydroxypyrimidine
Packaging
1g
Price
$403
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0025189
Product name
6-CHLORO-4-HYDROXYPYRIMIDINE
Purity
95.00%
Packaging
1G
Price
$779.78
Updated
2021/12/16
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6-Chloropyrimidin-4(3H)-one Chemical Properties,Usage,Production

Chemical Properties

Off-White to Pale Yellowish Solid

Uses

4-Chloro-6-hydroxypyrimidine (cas# 4765-77-9) is a compound useful in organic synthesis.

Definition

ChEBI: 6-Chloro-4-pyrimidinol is an organohalogen compound and a member of pyrimidines.

Synthesis

1193-21-1

4765-77-9

The general procedure for the synthesis of 6-chloropyrimidin-4(3H)-ones from 4,6-dichloropyrimidines is as follows: Intermediate 1: Synthesis of 6-chloro-3H-pyrimidin-4-one 4,6-Dichloropyrimidine (Aldrich; 10.00 g, 67.1 mmol), concentrated hydrochloric acid (50 mL), water (50 mL), and dioxane (50 mL) were mixed and heated at 70 °C for 6 h, and subsequently cooled to room temperature to obtain a pink solution. The solvent was removed by evaporation under reduced pressure (using a vacuum pump) to obtain a pink solid. Ethanol (50 mL) was added to the solid and the mixture was heated until the solid was completely dissolved. The solution was cooled slowly in a warm water bath at about 50°C. After standing overnight, it was filtered to obtain an off-white solid, 6-chloro-3H-pyrimidin-4-one (5.02 g, 57% yield), with a melting point of 193-194°C (literature value: 192-193°C, see DJ Brown and JS Harper, J. Chem. Soc. 1961, 1298-1303). 1H NMR (d6-DMSO) data: δ 6.50 (s, 1H), 8.19 (s, 1H), 13.00 (br s, 1H).

References

[1] Journal of the Chinese Chemical Society, 2013, vol. 60, # 1, p. 27 - 34
[2] Patent: US2009/149466, 2009, A1
[3] Patent: WO2017/59080, 2017, A1. Location in patent: Page/Page column 288; 289

6-Chloropyrimidin-4(3H)-one Preparation Products And Raw materials

Raw materials

4,6-Dichloropyrimidine Ethyl acetate Hydrochloric acid Diisopropyl ether Ammonia

Preparation Products

ETRIMFOS
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View Lastest Price from 6-Chloropyrimidin-4(3H)-one manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-Chloro-6-hydroxypyriMidine 4765-77-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-14
Career Henan Chemical Co
Product
6-Chloropyrimidin-4(3H)-one 4765-77-9
Price
US $1.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
500kg
Release date
2018-08-19

4765-77-9, 6-Chloropyrimidin-4(3H)-oneRelated Search:

Trazodone Chlormezanone 3'-Chloroacetophenone Chlortalidone 6-CHLORO-2,4-DIMETHOXYPYRIMIDINE 2,4-Dichloro-6-methoxypyrimidine 2-AMINO-4-CHLORO-6-ETHOXYPYRIMIDINE 2-Amino-4-chloro-6-methoxypyrimidine Difluorochloromethane KETAMINE/ZYLAZINE SOLUTION--SCHEDULE*III ITEM 4-chloro-6-methoxy-2-methylpyrimidin-5-amine 2-AMINO-6-CHLORO-4-PYRIMIDINOL HYDRATE, 95 6-Chlorouracil Moxonidine 2-Amino-6-chloro-4-pyrimidinol (6-CHLOROPYRIDAZIN-3-YL)(PHENYL)METHANONE 4-Hydroxypyrimidine Chlorimuron-ethyl

  • 6-CHLOROPYRIMIDIN-4(3H)-ONE
  • 6-CHLOROPYRIMIDIN-4-OL
  • 6-Chloro-4-pyrimidinol
  • 6-CHLORO-4-HYDROXYPYRIMIDINE
  • 4(1H)-Pyrimidinone, 6-chloro- (9CI)
  • 6-Chloro-4(1H)-Pyrimidinone
  • 6-CHLORO-4-HYDROXYPYRIMIDINE,98%
  • 6-chloropyrimidin-4(1H)-one
  • 4-Chloropyrimidin-6-one
  • 6-chloro-4(3H)-Pyrimidinone
  • NSC 618279
  • 4(1H)-Pyrimidinone, 6-chloro-
  • 6-Chloro-3,4-dihydro-4-oxopyrimidine
  • 4-hydroxy-6-chloropyriMidine
  • 6-Chloro-4-pyrimidinol 6-Chloro-4(1H)-pyrimidinone
  • 6-chloropyriMidine-4-ol
  • 4-CHLORO-6-HYDROXYPYRIMIDINE
  • 6-Chloro-1,4-dihydropyrimidin-4-one
  • 4-Chloro-6-hydroxypyrimidine &gt
  • 6-Chlorpyrimidin-4-ol
  • 4765-77-9
  • 765-77-9
  • Bases & Related Reagents
  • Nucleotides
  • Heterocycle-Pyrimidine series
  • Heterocycles
  • Nucleotides and Nucleosides
  • PYRIMIDINE
  • APIs & Intermediate