2,4-Dichloro-6-methoxypyrimidine
- Product Name
- 2,4-Dichloro-6-methoxypyrimidine
- CAS No.
- 43212-41-5
- Chemical Name
- 2,4-Dichloro-6-methoxypyrimidine
- Synonyms
- 2,4-Dichloro-6-methoxypyrimidine;2,6-Dichloro-4-methoxypyrimidine;2,4-Dichloro-6-methoxy-1,3-diazine;Pyrimidine, 2,4-dichloro-6-methoxy-;2,4-Dichloro-6-methoxypyrimidine,>97%;2,4-Dichloro-6-methoxypyrimidine ISO 9001：2015 REACH
- CBNumber
- CB22203876
- Molecular Formula
- C5H4Cl2N2O
- Formula Weight
- 179
- MOL File
- 43212-41-5.mol
2,4-Dichloro-6-methoxypyrimidine Property
- Boiling point:
- 263.2±20.0 °C(Predicted)
- Density
- 1.446±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -4.54±0.30(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C5H4Cl2N2O/c1-10-4-2-3(6)8-5(7)9-4/h2H,1H3
- InChIKey
- ZSNZDRHTTWBNGI-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(OC)=CC(Cl)=N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P308+P313IF exposed or concerned: Get medical advice/attention.
P363Wash contaminated clothing before reuse.
P403Store in a well-ventilated place.
N-Bromosuccinimide Price
- Product number
- D435310
- Product name
- 2,4-Dichloro-6-methoxypyrimidine
- Packaging
- 100mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FD71632
- Product name
- 2,4-Dichloro-6-methoxypyrimidine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- W6269
- Product name
- 2,4-Dichloro-6-methoxypyrimidine
- Packaging
- 100mg
- Price
- $77
- Updated
- 2021/12/16
- Product number
- OR301155
- Product name
- 2,4-Dichloro-6-methoxypyrimidine
- Packaging
- 250mg
- Price
- $87
- Updated
- 2021/12/16
- Product number
- 4H07-5-02
- Product name
- 2,4-Dichloro-6-methoxypyrimidine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $96
- Updated
- 2021/12/16
2,4-Dichloro-6-methoxypyrimidine Chemical Properties,Usage,Production
Uses
2,4-Dichloro-6-methoxypyrimidine is an intermediate used to prepare piperazinyl pyrimidine derivatives as γ-secretase modulators. It is also used in the synthesis of α-azinylalkylamino-substituted (thiazolylamino)pyrimidines and -pyrazines as selective JAK2 inhibitors.
Synthesis
29458-38-6
43212-41-5
General procedure for the synthesis of 2,4-dichloro-6-methoxypyrimidine from 6-methoxypyrimidine-2,4(1H,3H)-dione: 6-methoxypyrimidine-2,4(1H,3H)-dione (15 g, 0.106 mol) was mixed with phosphorus triclosan (400 ml) and heated and refluxed for 4 h. After completion of the reaction the excess of phosphorus triclosan was removed by distillation under reduced pressure. The residue was quenched with an ice-water mixture and extracted with ethyl acetate (EtOAc). The organic phases were combined, washed with water, dried over anhydrous sodium sulfate (Na2SO4), and concentrated under reduced pressure to remove the solvent to afford 2,4-dichloro-6-methoxypyrimidine as an oil (5.5 g, 30% yield). Nuclear Magnetic Resonance Hydrogen Spectroscopy (NMR) data: δ 3.96 (3H, single peak), 6.63 (1H, single peak); Mass Spectrum (m/z): 179 [MH]+.
References
[1] Patent: WO2007/31745, 2007, A1. Location in patent: Page/Page column 96
[2] Organic Process Research and Development, 2012, vol. 16, # 8, p. 1416 - 1421
[3] Patent: WO2006/109026, 2006, A1. Location in patent: Page/Page column 97
[4] Patent: WO2008/117051, 2008, A1. Location in patent: Page/Page column 29
[5] Patent: WO2016/168619, 2016, A1. Location in patent: Paragraph 00162
2,4-Dichloro-6-methoxypyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-Dichloro-6-methoxypyrimidine manufacturers
- Product
- 2,4-Dichloro-6-methoxypyrimidine 43212-41-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-13
- Product
- 2,4-Dichloro-6-methoxypyrimidine 43212-41-5
- Price
- US $0.37/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10kg/100kg
- Release date
- 2020-11-09