2,4-dichloro-6-phenylpyrimidine
- Product Name
- 2,4-dichloro-6-phenylpyrimidine
- CAS No.
- 26032-72-4
- Chemical Name
- 2,4-dichloro-6-phenylpyrimidine
- Synonyms
- NSC 49018;2,4-dichloro-6-phenylpyrimidine;PyriMidine,2,4-dichloro-6-phenyl-
- CBNumber
- CB11078261
- Molecular Formula
- C10H6Cl2N2
- Formula Weight
- 225.07
- MOL File
- 26032-72-4.mol
2,4-dichloro-6-phenylpyrimidine Property
- Melting point:
- 92-93℃
- Boiling point:
- 361.2±22.0 °C(Predicted)
- Density
- 1.363±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to crystal
- pka
- -3.45±0.30(Predicted)
- color
- White to Light yellow
- CAS DataBase Reference
- 26032-72-4
Safety
- HS Code
- 2933.59.9500
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D5505
- Product name
- 2,4-Dichloro-6-phenylpyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $141
- Updated
- 2025/07/31
- Product number
- D5505
- Product name
- 2,4-Dichloro-6-phenylpyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $501
- Updated
- 2025/07/31
- Product number
- B419503
- Product name
- 2,4-Dichloro-6-phenylpyrimidine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 2210AB
- Product name
- 2,4-Dichloro-6-phenylpyrimidine
- Packaging
- 1g
- Price
- $205
- Updated
- 2021/12/16
- Product number
- NUC0001603
- Product name
- 2,4-DICHLORO-6-PHENYLPYRIMIDINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $330.75
- Updated
- 2021/12/16
2,4-dichloro-6-phenylpyrimidine Chemical Properties,Usage,Production
Chemical Properties
white powder
Synthesis Reference(s)
The Journal of Organic Chemistry, 53, p. 4137, 1988 DOI: 10.1021/jo00252a057
Synthesis
13345-09-0
26032-72-4
Step 2: Synthesis of 2,4-dichloro-6-phenylpyrimidine; in 50.0 ml of reaction system. To a round-bottomed flask equipped with a magnetic stirrer and a reflux condenser, protected by argon, 6-phenylpyrimidine-2,4(1H,3H)-dione (2.22 g, 11.8 mmol) and phosphorus trichloride (11.0 ml, 118 mmol) were added. The flask was placed in an oil bath preheated to 116 °C and rapidly heated to reflux. The reaction mixture was stirred at 116 °C for 4 h in an argon atmosphere and subsequently cooled to room temperature. The reaction progress was monitored by LC-MS (m/e 225 [M + H]+) to confirm product generation. Subsequently, a short-range distillation unit was installed to remove the excess phosphorus trichloride by decompression distillation at 116 °C. The residue was further distilled at ~70 °C to remove unreacted feedstock. The crude product was cooled to -3°C (using an ice bath and monitoring the temperature via a built-in thermometer). The reaction was quenched by the slow addition of ice water while keeping the temperature below 10°C. The reaction mixture was continued to be stirred in an ice bath for 60 minutes to induce precipitation of the product. The precipitate was collected by vacuum filtration and analyzed by LC-MS and confirmed to be the target product 2,4-dichloro-6-phenylpyrimidine (1.74 g, 7.7 mmol, 65% yield). m/e MS (ES) 225 [M + H]+.
References
[1] Patent: WO2009/97474, 2009, A1. Location in patent: Page/Page column 35
[2] Yakugaku Zasshi, 1950, vol. 70, p. 137
[3] Chem.Abstr., 1950, p. 5886
[4] Journal of Medicinal Chemistry, 2011, vol. 54, # 2, p. 510 - 524
2,4-dichloro-6-phenylpyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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