2,4-DICHLORO-5,7-DIHYDROFURO[3,4-D]PYRIMIDINE
- Product Name
- 2,4-DICHLORO-5,7-DIHYDROFURO[3,4-D]PYRIMIDINE
- CAS No.
- 848398-41-4
- Chemical Name
- 2,4-DICHLORO-5,7-DIHYDROFURO[3,4-D]PYRIMIDINE
- Synonyms
- 2,4-dichloro-5H,7H-furo[3,4-d]pyrimidine;2,4-DICHLORO-5,7-DIHYDROFURO[3,4-D]PYRIMIDINE;Furo[3,4-d]pyrimidine, 2,4-dichloro-5,7-dihydro-;2,4-dichloro-5,7-dihydrofurano [3,4-d] pyrimidine
- CBNumber
- CB22468938
- Molecular Formula
- C6H4Cl2N2O
- Formula Weight
- 191.01
- MOL File
- 848398-41-4.mol
2,4-DICHLORO-5,7-DIHYDROFURO[3,4-D]PYRIMIDINE Property
- Boiling point:
- 337.8±42.0 °C(Predicted)
- Density
- 1.592±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -3.43±0.20(Predicted)
- Appearance
- Light yellow to brown Solid
Safety
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D433965
- Product name
- 2,4-Dichloro-5,7-dihydrofuro[3,4-d]pyrimidine
- Packaging
- 100mg
- Price
- $135
- Updated
- 2021/12/16
- Product number
- D433965
- Product name
- 2,4-Dichloro-5,7-dihydrofuro[3,4-d]pyrimidine
- Packaging
- 250mg
- Price
- $295
- Updated
- 2021/12/16
- Product number
- D433965
- Product name
- 2,4-Dichloro-5,7-dihydrofuro[3,4-d]pyrimidine
- Packaging
- 500mg
- Price
- $580
- Updated
- 2021/12/16
- Product number
- FD142103
- Product name
- 2,4-Dichloro-5,7-dihydrofuro[3,4-d]pyrimidine
- Packaging
- 1g
- Price
- $681.25
- Updated
- 2021/12/16
- Product number
- 101665
- Product name
- 2,4-Dichloro-5,7-dihydrofuro[3,4-d]pyrimidine
- Purity
- 97%
- Packaging
- 500mg
- Price
- $887
- Updated
- 2021/12/16
2,4-DICHLORO-5,7-DIHYDROFURO[3,4-D]PYRIMIDINE Chemical Properties,Usage,Production
Uses
2,4-Dichloro-5,7-dihydrofuro[3,4-d]pyrimidine is used as a reagent in the synthesis of substituted pyrimidinediamines as potent dual BRD4-kinase inhibitors for treating cancer.
Synthesis
848398-40-3
848398-41-4
The general procedure for the synthesis of 2,4-dichloro-5,7-dihydrofuro[3,4-D]pyrimidine-2,4-diol from 5,7-dihydrofuro[3,4-D]pyrimidine-2,4-diol is as follows: to a solution of trichlorophosphine oxide (30 mL) of 5,7-dihydrofuro[3,4-D]pyrimidine-2,4-diol (500 mg, 3.25 mmol) was added, at 0 °C, a solution of dimethylaniline (500 mg, 4.13 mmol). The reaction mixture was heated to reflux for 12 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was carefully poured into ice (100 g) and extracted with dichloromethane (50 mL x 3). The organic layers were combined, washed with saturated brine and dried over anhydrous sodium sulfate. After filtration to remove the desiccant sodium sulfate, the organic solvent was removed by concentration under reduced pressure. Finally, the crude product was purified by fast column chromatography using a mixed solvent system of hexane and ethyl acetate to afford the target compound 2,4-dichloro-5,7-dihydrofuro[3,4-d]pyrimidine (300 mg, 49% yield). Mass spectrometry (LRMS) analysis showed the m/z value of (M + H+) to be: calculated value 192.01; measured value 192.10.
References
[1] Patent: WO2014/15291, 2014, A1. Location in patent: Page/Page column 181; 182
[2] Patent: EP1666468, 2006, A1. Location in patent: Page/Page column 32-33
2,4-DICHLORO-5,7-DIHYDROFURO[3,4-D]PYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-DICHLORO-5,7-DIHYDROFURO[3,4-D]PYRIMIDINE manufacturers
- Product
- 2,4-DICHLORO-5,7-DIHYDROFURO[3,4-D]PYRIMIDINE 848398-41-4
- Price
- US $8.00/KG
- Min. Order
- 1g
- Purity
- ＞98% HPLC
- Supply Ability
- kg--ton
- Release date
- 2020-02-20