2,4-Dichlorothieno[2,3-d]pyrimidine
Application- Product Name
- 2,4-Dichlorothieno[2,3-d]pyrimidine
- CAS No.
- 18740-39-1
- Chemical Name
- 2,4-Dichlorothieno[2,3-d]pyrimidine
- Synonyms
- 2,4-Dichlorothieno[2,3-d]...;2,4-Dichlorothieno[2,3-d]pyrimidine;Thieno[2,3-d]pyrimidine, 2,4-dichloro-;2,4-Dichlorothieno[2,3-d]pyrimidine ISO 9001：2015 REACH
- CBNumber
- CB2958369
- Molecular Formula
- C6H2Cl2N2S
- Formula Weight
- 205.06
- MOL File
- 18740-39-1.mol
2,4-Dichlorothieno[2,3-d]pyrimidine Property
- Boiling point:
- 274.8±22.0 °C(Predicted)
- Density
- 1.662±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- -0.84±0.40(Predicted)
- form
- crystalline powder
- color
- Pale yellow
- InChI
- InChI=1S/C6H2Cl2N2S/c7-4-3-1-2-11-5(3)10-6(8)9-4/h1-2H
- InChIKey
- HRXNGIQKOWQHCX-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(Cl)=C2C=CSC2=N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H319Causes serious eye irritation
- Precautionary statements
-
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SYX00043
- Product name
- 2,4-Dichlorothieno[2,3-d]pyrimidine
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $286
- Updated
- 2025/07/31
- Product number
- D436658
- Product name
- 2,4-Dichlorothieno[2,3-d]pyrimidine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- D436658
- Product name
- 2,4-Dichlorothieno[2,3-d]pyrimidine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- J99683
- Product name
- 2,4-Dichlorothieno[2,3-d]pyrimidine
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 070117
- Product name
- 2,4-Dichlorothieno[2,3-d]pyrimidine
- Purity
- >97%
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
2,4-Dichlorothieno[2,3-d]pyrimidine Chemical Properties,Usage,Production
Application
2,4-Dichlorothiophene[2,3-D]pyrimidine is an organic intermediate commonly used in the preparation of pharmaceutical products.
Synthesis
18740-38-0
18740-39-1
General procedure for the synthesis of 2,4-dichlorothieno[2,3-d]pyrimidines from 2,4-dihydroxythieno[2,3-d]pyrimidines: thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (12) (2.5 g, 0.012 mol) and a drop of N,N-dimethylformamide (DMF) were added to 20 mL phosphorus oxychloride (POCl3) . The reaction mixture was heated to 115°C and kept for 8 hours. After the reaction was completed, it was cooled to room temperature and the reaction mixture was slowly poured into 500 g of ice-water mixture. The solid product was collected by filtration and dissolved in dichloromethane (CH2Cl2). The insoluble material was removed by filtration and the filtrate was distilled under reduced pressure to give 1.7 g of 2,4-dichlorothieno[2,3-d]pyrimidine (13) in 56.0% yield. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6) δ 8.16 (d, J = 3.4 Hz, 1H, Ar-H), 7.62 (d, J = 3.4 Hz, 1H, Ar-H) and ESI-MS (m/z): 205.1 [M+H]+.
References
[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 22, p. 7815 - 7833
[2] Bulletin of the Korean Chemical Society, 2010, vol. 31, # 8, p. 2242 - 2246
[3] European Journal of Medicinal Chemistry, 2015, vol. 93, p. 64 - 73
[4] Patent: CN106831812, 2017, A. Location in patent: Paragraph 0091; 0092; 0093
[5] Patent: JP6120311, 2017, B2. Location in patent: Paragraph 0144-0145
2,4-Dichlorothieno[2,3-d]pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-Dichlorothieno[2,3-d]pyrimidine manufacturers
- Product
- 2,4-Dichlorothieno[2,3-d]pyrimidine 18740-39-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-12
- Product
- 2,4-Dichlorothieno[2,3-d]pyrimidine 18740-39-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-17
- Product
- 2,4-Dichlorothieno[2,3-d]pyrimidine 18740-39-1
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2018-12-24