2,4-DIBROMO-5-NITROPYRIDINE
- Product Name
- 2,4-DIBROMO-5-NITROPYRIDINE
- CAS No.
- 4487-57-4
- Chemical Name
- 2,4-DIBROMO-5-NITROPYRIDINE
- Synonyms
- 2,4-DIBROMO-5-NITROPYRIDINE;PRYIDEINE DERIVATIVE4487-57-4;Pyridine,2,4-dibromo-5-nitro-;2,4-Dibromo-5-nitropyridine 98%;2,4-DibroMo-5-nitropyridine DISCONTINUED;2,4-DIBROMO-5-NITROPYRIDINE ISO 9001：2015 REACH
- CBNumber
- CB11466442
- Molecular Formula
- C5H2Br2N2O2
- Formula Weight
- 281.89
- MOL File
- 4487-57-4.mol
2,4-DIBROMO-5-NITROPYRIDINE Property
- Melting point:
- 99 °C
- Boiling point:
- 292.0±35.0 °C(Predicted)
- Density
- 2?+-.0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.18±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C5H2Br2N2O2/c6-3-1-5(7)8-2-4(3)9(10)11/h1-2H
- InChIKey
- RZZGFCFQBVRQSX-UHFFFAOYSA-N
- SMILES
- C1(Br)=NC=C([N+]([O-])=O)C(Br)=C1
- CAS DataBase Reference
- 4487-57-4
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FD146951
- Product name
- 2,4-Dibromo-5-nitropyridine
- Packaging
- 5mg
- Price
- $66
- Updated
- 2021/12/16
- Product number
- CS-W019756
- Product name
- 2,4-Dibromo-5-nitropyridine
- Purity
- >97.0%
- Packaging
- 1g
- Price
- $66
- Updated
- 2021/12/16
- Product number
- OR315206
- Product name
- 2,4-Dibromo-5-nitropyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $111
- Updated
- 2021/12/16
- Product number
- FD146951
- Product name
- 2,4-Dibromo-5-nitropyridine
- Packaging
- 10mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- 4H54-9-73
- Product name
- 2,4-Dibromo-5-nitropyridine
- Packaging
- 1g
- Price
- $122
- Updated
- 2021/12/16
2,4-DIBROMO-5-NITROPYRIDINE Chemical Properties,Usage,Production
Uses
2,4-Dibromo-5-nitropyridine is a tri-substituted pyridine derivative used in the preparation of AKT kinase inhibitors and antihypertensive agents.
Synthesis
607373-82-0
4487-57-4
The general procedure for the synthesis of 2,4-dibromo-5-nitropyridine from 4-methoxy-5-nitropyridin-2(1H)-one is as follows: step 2. Phosphoribromide (5.73 g, 20 mmol) was slowly added to a suspension of the product of step 1 (1.70 g, 10 mmol) in acetonitrile (20 mL) at room temperature. Subsequently, the reaction mixture was heated to reflux and maintained for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and carefully poured into ice water and left to stratify. The aqueous layer was extracted with ethyl acetate (EtOAc) and the organic phases were combined. The organic phase was washed sequentially with water and saturated brine, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to give the title compound 2,4-dibromo-5-nitropyridine (2.1 g, 75% yield) as a dark solid.
References
[1] Patent: WO2005/37197, 2005, A2. Location in patent: Page/Page column 94
[2] Patent: WO2005/37197, 2005, A2. Location in patent: Page/Page column 94
[3] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 5, p. 1508 - 1511
[4] Patent: WO2006/113837, 2006, A2. Location in patent: Page/Page column 36; 63
[5] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 1, p. 42 - 46
2,4-DIBROMO-5-NITROPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-DIBROMO-5-NITROPYRIDINE manufacturers
- Product
- 2,4-DIBROMO-5-NITROPYRIDINE 4487-57-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-22
- Product
- 2,4-DIBROMO-5-NITROPYRIDINE 4487-57-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-14