ChemicalBook > CAS DataBase List > 2,4-Dichloro-6-methoxypyrimidine

2,4-Dichloro-6-methoxypyrimidine

Product Name: 2,4-Dichloro-6-methoxypyrimidine
CAS No.: 43212-41-5
Chemical Name: 2,4-Dichloro-6-methoxypyrimidine
Synonyms: 2,4-Dichloro-6-methoxypyrimidine;2,6-Dichloro-4-methoxypyrimidine;2,4-Dichloro-6-methoxy-1,3-diazine;Pyrimidine, 2,4-dichloro-6-methoxy-;2,4-Dichloro-6-methoxypyrimidine,>97%;2,4-Dichloro-6-methoxypyrimidine ISO 9001：2015 REACH
CBNumber: CB22203876
Molecular Formula: C5H4Cl2N2O
Formula Weight: 179
MOL File: 43212-41-5.mol

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2,4-Dichloro-6-methoxypyrimidine Property

Boiling point:: 263.2±20.0 °C(Predicted)
Density: 1.446±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -4.54±0.30(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C5H4Cl2N2O/c1-10-4-2-3(6)8-5(7)9-4/h2H,1H3
InChIKey: ZSNZDRHTTWBNGI-UHFFFAOYSA-N
SMILES: C1(Cl)=NC(OC)=CC(Cl)=N1

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Safety

Hazard Codes: Xn
Risk Statements: 22-36
Safety Statements: 26
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

TRC

Product number: D435310
Product name: 2,4-Dichloro-6-methoxypyrimidine
Packaging: 100mg
Price: $55
Updated: 2021/12/16

ChemScene

Product number: CS-W002709
Product name: 2,4-Dichloro-6-methoxypyrimidine
Purity: 99.97%
Packaging: 1g
Price: $52
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD71632
Product name: 2,4-Dichloro-6-methoxypyrimidine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: W6269
Product name: 2,4-Dichloro-6-methoxypyrimidine
Packaging: 100mg
Price: $77
Updated: 2021/12/16

Apolloscientific

Product number: OR301155
Product name: 2,4-Dichloro-6-methoxypyrimidine
Packaging: 250mg
Price: $87
Updated: 2021/12/16

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2,4-Dichloro-6-methoxypyrimidine Chemical Properties,Usage,Production

Uses

2,4-Dichloro-6-methoxypyrimidine is an intermediate used to prepare piperazinyl pyrimidine derivatives as γ-secretase modulators. It is also used in the synthesis of α-azinylalkylamino-substituted (thiazolylamino)pyrimidines and -pyrazines as selective JAK2 inhibitors.

Synthesis

29458-38-6

43212-41-5

General procedure for the synthesis of 2,4-dichloro-6-methoxypyrimidine from 6-methoxypyrimidine-2,4(1H,3H)-dione: 6-methoxypyrimidine-2,4(1H,3H)-dione (15 g, 0.106 mol) was mixed with phosphorus triclosan (400 ml) and heated and refluxed for 4 h. After completion of the reaction the excess of phosphorus triclosan was removed by distillation under reduced pressure. The residue was quenched with an ice-water mixture and extracted with ethyl acetate (EtOAc). The organic phases were combined, washed with water, dried over anhydrous sodium sulfate (Na2SO4), and concentrated under reduced pressure to remove the solvent to afford 2,4-dichloro-6-methoxypyrimidine as an oil (5.5 g, 30% yield). Nuclear Magnetic Resonance Hydrogen Spectroscopy (NMR) data: δ 3.96 (3H, single peak), 6.63 (1H, single peak); Mass Spectrum (m/z): 179 [MH]+.

References

[1] Patent: WO2007/31745, 2007, A1. Location in patent: Page/Page column 96
[2] Organic Process Research and Development, 2012, vol. 16, # 8, p. 1416 - 1421
[3] Patent: WO2006/109026, 2006, A1. Location in patent: Page/Page column 97
[4] Patent: WO2008/117051, 2008, A1. Location in patent: Page/Page column 29
[5] Patent: WO2016/168619, 2016, A1. Location in patent: Paragraph 00162

2,4-Dichloro-6-methoxypyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,4-Dichloro-6-methoxypyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2,4-Dichloro-6-methoxypyrimidine 43212-41-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-13

Career Henan Chemica Co

Product: 2,4-Dichloro-6-methoxypyrimidine 43212-41-5
Price: US $0.37/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg/100kg
Release date: 2020-11-09

43212-41-5, 2,4-Dichloro-6-methoxypyrimidineRelated Search:

2,4-DICHLORO-5,7-DIHYDROFURO[3,4-D]PYRIMIDINE 2,4-dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine HCl salt 2,4-Dichloro-3-iodopyridine 2,4-DIBROMO-3-CHLOROPYRIDINE 7-Benzyl-2,4-dichloro-5,6... 2,4-Dibromothiazole-5-methanol 2,4-DIBROMO-5-NITROPYRIDINE 2,4-dichloro-6-phenylpyrimidine 2,4-dichloro-5-iodo-6-methylpyrimidine CHEMPACIFIC 38112 2,4-DIBROMOBENZOTHIAZOLE 5-Thiazolecarboxylic acid, 2,4-dibromo- 2-CHLORO-4-METHOXYPYRIMIDINE 4-Chloro-6-methoxypyrimidine 2,4-Dichloro-6-methoxypyrimidine 6-Chloropyrimidin-4(3H)-one 4(1H)-Pyrimidinone, 2-chloro- (9CI) 2,4-DICHLORO-6-METHOXY-5-PHENYL-PYRIMIDINE

2,4-Dichloro-6-methoxypyrimidine

Pyrimidine, 2,4-dichloro-6-methoxy-

2,4-Dichloro-6-methoxy-1,3-diazine

2,6-Dichloro-4-methoxypyrimidine

2,4-Dichloro-6-methoxypyrimidine,>97%

2,4-Dichloro-6-methoxypyrimidine ISO 9001：2015 REACH

43212-41-5

Heterocycle-Pyrimidine series