4-Chloro-6-methoxypyrimidine
- Product Name
- 4-Chloro-6-methoxypyrimidine
- CAS No.
- 26452-81-3
- Chemical Name
- 4-Chloro-6-methoxypyrimidine
- Synonyms
- 4-CHLORO-6-METHOXYPYRIMIDINE;4-Chloro-6-methoxy-1,3-diazine;Pyrimidine, 4-chloro-6-methoxy-;4-Chloro-6-methoxypyrimidine >4-Chloro-6-methoxypyrimidine 98%;4-Chloro-6-methoxypyrimidine 98+%;6-CHLORO-4-PYRIMIDINYL METHYL ETHER;4-Chloro-6-MethoxypyriMidine（in stock）;4-Chloro-6-MethoxypyriMidine, 98.0%(GC);4-chloro-6-methoxypyrimidine(SALTDATA: FREE)
- CBNumber
- CB0729547
- Molecular Formula
- C5H5ClN2O
- Formula Weight
- 144.56
- MOL File
- 26452-81-3.mol
4-Chloro-6-methoxypyrimidine Property
- Melting point:
- 34.5-35.0 °C
- Boiling point:
- 80°C/18mmHg(lit.)
- Density
- 1.292±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to lump to clear liquid
- pka
- -1.59±0.17(Predicted)
- color
- White or Colorless to Light yellow
- InChI
- InChI=1S/C5H5ClN2O/c1-9-5-2-4(6)7-3-8-5/h2-3H,1H3
- InChIKey
- KLJGSQVYUGQOAW-UHFFFAOYSA-N
- SMILES
- C1=NC(OC)=CC(Cl)=N1
- CAS DataBase Reference
- 26452-81-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- C2369
- Product name
- 4-Chloro-6-methoxypyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $47
- Updated
- 2025/07/31
- Product number
- C2369
- Product name
- 4-Chloro-6-methoxypyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $188
- Updated
- 2025/07/31
- Product number
- C367888
- Product name
- 4-Chloro-6-methoxypyrimidine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- C367888
- Product name
- 4-Chloro-6-methoxypyrimidine
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 4H07-5-X8
- Product name
- 4-Chloro-6-methoxypyrimidine
- Purity
- 98.0%
- Packaging
- 1g
- Price
- $69
- Updated
- 2021/12/16
4-Chloro-6-methoxypyrimidine Chemical Properties,Usage,Production
Uses
4-Chloro-6-methoxypyrimidine could be the starting material for preparing 4-chloro-6-hydroxypyrimidine.
Synthesis
67-56-1
1193-21-1
26452-81-3
A) Methanol (5.4 mL) was slowly added dropwise to a suspension of tetrahydrofuran (THF, 200 mL) containing 60% sodium hydride (8.05 g) under nitrogen protection, keeping the reaction temperature at 0 °C. Subsequently, a solution of 4,6-dichloropyrimidine (20.0 g) in THF (45 mL) was added to the reaction system at 0 °C, and the reaction continued to be stirred at 0 °C for 1 hour. Upon completion of the reaction, 1N hydrochloric acid was slowly added to the reaction mixture at 0 °C for neutralization, followed by extraction of the reaction product with ethyl acetate. The organic phase was washed sequentially with water and saturated brine and dried with anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure and the residue was recrystallized by hexane to afford the target product 4-chloro-6-methoxypyrimidine (10.2 g) as light yellow crystals. The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 3.96 (3H, s), 7.19 (1H, s), 8.69 (1H, s).
References
[1] Tetrahedron Letters, 2005, vol. 46, # 23, p. 3977 - 3979
[2] European Journal of Medicinal Chemistry, 2005, vol. 40, # 9, p. 862 - 874
[3] Patent: US2013/143870, 2013, A1. Location in patent: Paragraph 0267; 0268; 0269
[4] Patent: US2013/137688, 2013, A1. Location in patent: Paragraph 0221; 0222; 0223; 0224
[5] Patent: US2013/158038, 2013, A1. Location in patent: Paragraph 0134; 0135
4-Chloro-6-methoxypyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Chloro-6-methoxypyrimidine manufacturers
- Product
- 4-Chloro-6-methoxypyrimidine 26452-81-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-12
- Product
- 4-Chloro-6-methoxypyrimidine 26452-81-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 4-Chloro-6-methoxypyrimidine 26452-81-3
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- customise
- Release date
- 2018-08-09