Moxonidine
Description Physical and Chemical Properties Application Preparation Precautions References- Product Name
- Moxonidine
- CAS No.
- 75438-57-2
- Chemical Name
- Moxonidine
- Synonyms
- Cynt;LoMox;be5895;Nucynt;bdf5895;Norcynt;Moxonidin;MOXONIDINE;NorMoxocin;Physiotens
- CBNumber
- CB8121013
- Molecular Formula
- C9H12ClN5O
- Formula Weight
- 241.68
- MOL File
- 75438-57-2.mol
Moxonidine Property
- Melting point:
- 217-219° (dec)
- Boiling point:
- 364.7±52.0 °C(Predicted)
- Density
- 1.52±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Very slightly soluble in water, sparingly soluble in methanol, slightly soluble in methylene chloride, very slightly soluble in acetonitrile.
- pka
- 7.11±0.10(Predicted)
- color
- White to Almost white
- Water Solubility
- 800.3mg/L(temperature not stated)
- Merck
- 14,6293
- InChIKey
- WPNJAUFVNXKLIM-UHFFFAOYSA-N
- CAS DataBase Reference
- 75438-57-2(CAS DataBase Reference)
Safety
- RIDADR
- UN 2811 6.1/PG III
- WGK Germany
- 3
- RTECS
- UV6260290
- HS Code
- 2933.99.5300
- HazardClass
- 6.1
- PackingGroup
- III
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- Y0000226
- Product name
- Moxonidine
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0000226
- Price
- $150
- Updated
- 2024/03/01
- Product number
- M2660
- Product name
- Moxonidine
- Purity
- >98.0%(T)
- Packaging
- 200mg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- M2660
- Product name
- Moxonidine
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $406
- Updated
- 2024/03/01
- Product number
- 25639
- Product name
- Moxonidine
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 25639
- Product name
- Moxonidine
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $321
- Updated
- 2024/03/01
Moxonidine Chemical Properties,Usage,Production
Description
Moxonidine, also known as Physiotens, is a highly selective imidazoline receptor agonist-Ⅰ by excitement ventrolateral medulla nucleus (RVLM)-Ⅰ type imidazoline receptor in the peripheral sympathetic nerve activity decreased. This receptor subtype is found in both the rostral ventro-lateral pressor and ventromedial depressor areas of the medulla oblongata.
Moxonidine therefore causes a decrease in sympathetic nervous system activity and, therefore, a decrease in blood pressure.
It is a new type of antihypertensive drug, commonly used in the treatment of essential hypertension. Compared to the older central-acting antihypertensives, moxonidine binds with much greater affinity to the imidazoline I1-receptor than to the α2-receptor. In contrast, clonidine binds to both receptors with equal affinity.
It may have a role when thiazides, beta-blockers, ACE inhibitors and calcium channel blockers are not appropriate or have failed to control blood pressure.
Physical and Chemical Properties
ensity: 1.52g/cm3, boiling point: 364.7 °C at 760 mmHg, flash point: 174.3 °C, crystallization, melting point: 217-219 degrees Celsius.
Application
- By stimulating the central presynaptic alpha 2-receptor and onset, and its antihypertensive effect of ACE inhibitors, calcium antagonists nifedipine and captopril similar. Treatment of essential hypertension.
- The intervention of renal interstitial fibrosis can protect the kidney.
Preparation
5-amino-4,6-dichloro-2-methyl pyrimidine and 1-acetyl-2-imidazolin-2-one. The product, reacting with sodium methanol can produce moxonidine.
Precautions
- There may be dry mouth, fatigue and headache at the beginning of treatment, occasional dizziness, insomnia, and weakness in the legs and so on.
- Sick sinus syndrome, the sinus node and atrioventricular Ⅱ-Ⅲ degree block, resting bradycardia (50 beats/min), unstable angina, severe liver disease, progressive renal dysfunction, angioedema patients should not use it.
References
https://en.wikipedia.org/wiki/Moxonidine
Description
Moxonidine, which is structurally related to clonidine, is a new centrally acting antihypertensive that acts as a stronger agonist at imidazole receptors and a weaker agonist at α2-adrenergic receptors than clonidine. It is also reported to have less side effects and a much reduced potential to produce a rebound in blood pressure on withdrawal. Clinically, moxonidine appears to have comparable antihypertensive efficacy with the ACE inhibitors and calcium antagonists.
Chemical Properties
White Solid
Originator
Beiersdorf (Germany)
Uses
Antihypertensive;Imidazoline receptor agonist
Uses
Moxonidine is an antihypertensive agent.
Definition
ChEBI: Moxonidine is an organohalogen compound and a member of pyrimidines.
brand name
Cynt (Lilly); Nucynt (Lilly); Norcynt (Lilly);Physiotens.
Biological Activity
Mixed I 1 imidazoline receptor and α 2 -adrenergic agonist; displays 40-fold higher affinity for I 1 receptors versus α 2 -adrenoceptors. Centrally acting antihypertensive agent.
Clinical Use
Antihypertensive agent (centrally acting agonist at I1 receptor, imidazoline and alpha2 adrenoceptors)
Metabolism
10-20% metabolised, predominantly to 4,5-dehydromoxonidine and to an aminomethanamidine derivative both of which are much less active than moxonidine. Moxonidine and its metabolites are almost entirely eliminated via the kidney. More than 90% of the dose is eliminated in the first 24 hours via the kidney, while approximately 1% is eliminated in the faeces
Moxonidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Moxonidine manufacturers
- Product
- Moxonidine 75438-57-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2024-04-08
- Product
- Moxonidine 75438-57-2
- Price
- US $0.00/Kg/Bag
- Min. Order
- 50g
- Purity
- 97.5%-102%
- Supply Ability
- 1000g
- Release date
- 2021-08-20
- Product
- Moxonidine 75438-57-2
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 9000kg/per week
- Release date
- 2021-05-19