Description Physical and Chemical Properties Application Preparation Precautions References
ChemicalBook > CAS DataBase List > Moxonidine

Moxonidine

Description Physical and Chemical Properties Application Preparation Precautions References
Product Name
Moxonidine
CAS No.
75438-57-2
Chemical Name
Moxonidine
Synonyms
Cynt;LoMox;be5895;Nucynt;bdf5895;Norcynt;Moxonidin;MOXONIDINE;NorMoxocin;Physiotens
CBNumber
CB8121013
Molecular Formula
C9H12ClN5O
Formula Weight
241.68
MOL File
75438-57-2.mol
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Moxonidine Property

Melting point:
217-219° (dec)
Boiling point:
364.7±52.0 °C(Predicted)
Density 
1.52±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Very slightly soluble in water, sparingly soluble in methanol, slightly soluble in methylene chloride, very slightly soluble in acetonitrile.
form 
Solid
pka
7.11±0.10(Predicted)
color 
White to Almost white
Water Solubility 
800.3mg/L(temperature not stated)
Merck 
14,6293
InChIKey
WPNJAUFVNXKLIM-UHFFFAOYSA-N
CAS DataBase Reference
75438-57-2(CAS DataBase Reference)
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Safety

RIDADR 
UN 2811 6.1/PG III
WGK Germany 
3
RTECS 
UV6260290
HS Code 
2933.99.5300
HazardClass 
6.1
PackingGroup 
III
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0000226
Product name
Moxonidine
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0000226
Price
$150
Updated
2024/03/01
TCI Chemical
Product number
M2660
Product name
Moxonidine
Purity
>98.0%(T)
Packaging
200mg
Price
$117
Updated
2024/03/01
TCI Chemical
Product number
M2660
Product name
Moxonidine
Purity
>98.0%(T)
Packaging
1g
Price
$406
Updated
2024/03/01
Cayman Chemical
Product number
25639
Product name
Moxonidine
Purity
≥95%
Packaging
10mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
25639
Product name
Moxonidine
Purity
≥95%
Packaging
50mg
Price
$321
Updated
2024/03/01
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Moxonidine Chemical Properties,Usage,Production

Description

Moxonidine, also known as Physiotens, is a highly selective imidazoline receptor agonist-Ⅰ by excitement ventrolateral medulla nucleus (RVLM)-Ⅰ type imidazoline receptor in the peripheral sympathetic nerve activity decreased. This receptor subtype is found in both the rostral ventro-lateral pressor and ventromedial depressor areas of the medulla oblongata.
Moxonidine therefore causes a decrease in sympathetic nervous system activity and, therefore, a decrease in blood pressure.
It is a new type of antihypertensive drug, commonly used in the treatment of essential hypertension. Compared to the older central-acting antihypertensives, moxonidine binds with much greater affinity to the imidazoline I1-receptor than to the α2-receptor. In contrast, clonidine binds to both receptors with equal affinity.
It may have a role when thiazides, beta-blockers, ACE inhibitors and calcium channel blockers are not appropriate or have failed to control blood pressure.

Physical and Chemical Properties

ensity: 1.52g/cm3, boiling point:  364.7 °C at 760 mmHg, flash point: 174.3 °C, crystallization, melting point: 217-219 degrees Celsius.

Application

  • By stimulating the central presynaptic alpha 2-receptor and onset, and its antihypertensive effect of ACE inhibitors, calcium antagonists nifedipine and captopril similar. Treatment of essential hypertension.
  • The intervention of renal interstitial fibrosis can protect the kidney.

Preparation

5-amino-4,6-dichloro-2-methyl pyrimidine and 1-acetyl-2-imidazolin-2-one. The product, reacting with sodium methanol can produce moxonidine.

Precautions

  • There may be dry mouth, fatigue and headache at the beginning of treatment, occasional dizziness, insomnia, and weakness in the legs and so on.
  • Sick sinus syndrome, the sinus node and atrioventricular Ⅱ-Ⅲ degree block, resting bradycardia (50 beats/min), unstable angina, severe liver disease, progressive renal dysfunction, angioedema patients should not use it.

References

https://en.wikipedia.org/wiki/Moxonidine

Description

Moxonidine, which is structurally related to clonidine, is a new centrally acting antihypertensive that acts as a stronger agonist at imidazole receptors and a weaker agonist at α2-adrenergic receptors than clonidine. It is also reported to have less side effects and a much reduced potential to produce a rebound in blood pressure on withdrawal. Clinically, moxonidine appears to have comparable antihypertensive efficacy with the ACE inhibitors and calcium antagonists.

Chemical Properties

White Solid

Originator

Beiersdorf (Germany)

Uses

Antihypertensive;Imidazoline receptor agonist

Uses

Moxonidine is an antihypertensive agent.

Definition

ChEBI: Moxonidine is an organohalogen compound and a member of pyrimidines.

brand name

Cynt (Lilly); Nucynt (Lilly); Norcynt (Lilly);Physiotens.

Biological Activity

Mixed I 1 imidazoline receptor and α 2 -adrenergic agonist; displays 40-fold higher affinity for I 1 receptors versus α 2 -adrenoceptors. Centrally acting antihypertensive agent.

Clinical Use

Antihypertensive agent (centrally acting agonist at I1 receptor, imidazoline and alpha2 adrenoceptors)

Metabolism

10-20% metabolised, predominantly to 4,5-dehydromoxonidine and to an aminomethanamidine derivative both of which are much less active than moxonidine. Moxonidine and its metabolites are almost entirely eliminated via the kidney. More than 90% of the dose is eliminated in the first 24 hours via the kidney, while approximately 1% is eliminated in the faeces

Moxonidine Preparation Products And Raw materials

Raw materials

Ethylenediamine 4,6-Dichloro-2-methylpyrimidine Ammonium thiocyanate 4,5-dihydro-1H-imidazole

Preparation Products

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View Lastest Price from Moxonidine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Moxonidine 75438-57-2
Price
US $0.00/Kg/Bag
Min. Order
50g
Purity
97.5%-102%
Supply Ability
1000g
Release date
2021-08-20
Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
Moxonidine 75438-57-2
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2024-04-08
Zhuozhou Wenxi import and Export Co., Ltd
Product
Moxonidine 75438-57-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

75438-57-2, MoxonidineRelated Search:

(Trifluoromethoxy)benzene 1-Methylimidazole MOXONIDINE HYDROCHLORIDE,MOXONIDINE HCL 5-METHYLCYTOSINE Pirimiphos-methyl Mestinon Bendazac L-lysine Losartan potassium Fursultiamine Terazosin Lovastatin 4-chloro-6-methoxy-2-methyl-N-(4,4,5,5-tetradeuterio-1H-imidazol-2-yl)pyrimidin-5-amine 5-Amino-4,6-dichloro-2-methylpyrimidine 4-chloro-6-methoxy-2-methylpyrimidin-5-amine 4-Chloro-6-methoxypyrimidine Imidazole Pyrimidine 6-Chloropyrimidin-4(3H)-one

  • MOXONIDINE
  • MOXONIDINE HCL
  • 4-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamin
  • bdf5895
  • be5895
  • BDF-5895 HCL
  • 4-CHLORO-6-METHOXY-2-METHYL-5-(2-IMIDAZOLIN-2-YL)AMINOPYRIMIDINE HCL
  • 4-CHLORO-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-6-METHOXY-2-METHYL-5-PYRIMIDINAMINE HYDROCHLORIDE
  • Moxonidin
  • 4-Chloro-5-(2-imidazolin-2-ylamino)-6-methoxy-2-methylpyrimidine
  • MOXONIDINE/4-CHLORO-N-(4,5-DIHYDRO-1H-2-IMIDAZOLYL)-6-METHOXY-2-METHYL-5-PYRAMINE
  • 4-Chloro-N-(4，5-dihydro-1H-imidaml-2-y1)-6-methoxy-2-methyl-5-pyrimidinamine
  • Cynt
  • Physioterls
  • 4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamine
  • 4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methylpyrimidin-5-amine
  • Norcynt
  • (4-chloro-6-methoxy-2-methyl-pyrimidin-5-yl)-(4,5-dihydro-1H-imidazol-2-yl)amine
  • 5-Pyrimidinamine, 4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-
  • 2-(6-Chloro-4-Methoxy-2-MethylpyriMidin-5-ylaMino)-2-iMidazoline
  • LoMox
  • NorMoxocin
  • Nucynt
  • Physiotens
  • Moxonidine-d3
  • 4-Chloro-6-methoxy-2-methyl-5-(2-imidazolin-2-yl)aminopyrimidine hydrochloride
  • 4-chloro-N-imidazolidin-2-ylidene-6-methoxy-2-methylpyrimidin-5-amine
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  • 75438-57-2
  • C9H12ClN5O
  • C9H12Cl5O
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