Moxonidine

ChemicalBook > CAS DataBase List > Moxonidine

Description Physical and Chemical Properties Application Preparation Precautions References

Product Name: Moxonidine
CAS No.: 75438-57-2
Chemical Name: Moxonidine
Synonyms: Cynt;LoMox;be5895;Nucynt;bdf5895;Norcynt;Moxonidin;MOXONIDINE;NorMoxocin;Physiotens
CBNumber: CB8121013
Molecular Formula: C9H12ClN5O
Formula Weight: 241.68
MOL File: 75438-57-2.mol

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Moxonidine Property

Melting point:: 217-219° (dec)
Boiling point:: 364.7±52.0 °C(Predicted)
Density: 1.52±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Very slightly soluble in water, sparingly soluble in methanol, slightly soluble in methylene chloride, very slightly soluble in acetonitrile.
pka: 7.11±0.10(Predicted)
color: White to Almost white
Water Solubility: 800.3mg/L(temperature not stated)
Merck: 14,6293
InChIKey: WPNJAUFVNXKLIM-UHFFFAOYSA-N
CAS DataBase Reference: 75438-57-2(CAS DataBase Reference)

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Safety

RIDADR: UN 2811 6.1/PG III
WGK Germany: 3
RTECS: UV6260290
HS Code: 2933.99.5300
HazardClass: 6.1
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0000226
Product name: Moxonidine
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000226
Price: $150
Updated: 2024/03/01

TCI Chemical

Product number: M2660
Product name: Moxonidine
Purity: >98.0%(T)
Packaging: 200mg
Price: $117
Updated: 2024/03/01

TCI Chemical

Product number: M2660
Product name: Moxonidine
Purity: >98.0%(T)
Packaging: 1g
Price: $406
Updated: 2024/03/01

Cayman Chemical

Product number: 25639
Product name: Moxonidine
Purity: ≥95%
Packaging: 10mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 25639
Product name: Moxonidine
Purity: ≥95%
Packaging: 50mg
Price: $321
Updated: 2024/03/01

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Moxonidine Chemical Properties,Usage,Production

Description

Moxonidine, also known as Physiotens, is a highly selective imidazoline receptor agonist-Ⅰ by excitement ventrolateral medulla nucleus (RVLM)-Ⅰ type imidazoline receptor in the peripheral sympathetic nerve activity decreased. This receptor subtype is found in both the rostral ventro-lateral pressor and ventromedial depressor areas of the medulla oblongata.
Moxonidine therefore causes a decrease in sympathetic nervous system activity and, therefore, a decrease in blood pressure.
It is a new type of antihypertensive drug, commonly used in the treatment of essential hypertension. Compared to the older central-acting antihypertensives, moxonidine binds with much greater affinity to the imidazoline I1-receptor than to the α2-receptor. In contrast, clonidine binds to both receptors with equal affinity.
It may have a role when thiazides, beta-blockers, ACE inhibitors and calcium channel blockers are not appropriate or have failed to control blood pressure.

Physical and Chemical Properties

ensity: 1.52g/cm3, boiling point: 364.7 °C at 760 mmHg, flash point: 174.3 °C, crystallization, melting point: 217-219 degrees Celsius.

Application

By stimulating the central presynaptic alpha 2-receptor and onset, and its antihypertensive effect of ACE inhibitors, calcium antagonists nifedipine and captopril similar. Treatment of essential hypertension.
The intervention of renal interstitial fibrosis can protect the kidney.

Preparation

5-amino-4,6-dichloro-2-methyl pyrimidine and 1-acetyl-2-imidazolin-2-one. The product, reacting with sodium methanol can produce moxonidine.

Precautions

There may be dry mouth, fatigue and headache at the beginning of treatment, occasional dizziness, insomnia, and weakness in the legs and so on.
Sick sinus syndrome, the sinus node and atrioventricular Ⅱ-Ⅲ degree block, resting bradycardia (50 beats/min), unstable angina, severe liver disease, progressive renal dysfunction, angioedema patients should not use it.

References

https://en.wikipedia.org/wiki/Moxonidine

Description

Moxonidine, which is structurally related to clonidine, is a new centrally acting antihypertensive that acts as a stronger agonist at imidazole receptors and a weaker agonist at α2-adrenergic receptors than clonidine. It is also reported to have less side effects and a much reduced potential to produce a rebound in blood pressure on withdrawal. Clinically, moxonidine appears to have comparable antihypertensive efficacy with the ACE inhibitors and calcium antagonists.

Chemical Properties

White Solid

Originator

Beiersdorf (Germany)

Uses

Antihypertensive;Imidazoline receptor agonist

Uses

Moxonidine is an antihypertensive agent.

Definition

ChEBI: Moxonidine is an organohalogen compound and a member of pyrimidines.

brand name

Cynt (Lilly); Nucynt (Lilly); Norcynt (Lilly);Physiotens.

Biological Activity

Mixed I 1 imidazoline receptor and α 2 -adrenergic agonist; displays 40-fold higher affinity for I 1 receptors versus α 2 -adrenoceptors. Centrally acting antihypertensive agent.

Clinical Use

Antihypertensive agent (centrally acting agonist at I1 receptor, imidazoline and alpha2 adrenoceptors)

Metabolism

10-20% metabolised, predominantly to 4,5-dehydromoxonidine and to an aminomethanamidine derivative both of which are much less active than moxonidine. Moxonidine and its metabolites are almost entirely eliminated via the kidney. More than 90% of the dose is eliminated in the first 24 hours via the kidney, while approximately 1% is eliminated in the faeces

Moxonidine Preparation Products And Raw materials

Raw materials

Ethylenediamine 4,6-Dichloro-2-methylpyrimidine Ammonium thiocyanate 4,5-dihydro-1H-imidazole

Preparation Products

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Moxonidine Suppliers

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View Lastest Price from Moxonidine manufacturers

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Moxonidine 75438-57-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20tons
Release date: 2024-04-08

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Moxonidine 75438-57-2
Price: US $0.00/Kg/Bag
Min. Order: 50g
Purity: 97.5%-102%
Supply Ability: 1000g
Release date: 2021-08-20

Hebei Lingding Biotechnology Co., Ltd.

Product: Moxonidine 75438-57-2
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 9000kg/per week
Release date: 2021-05-19

75438-57-2, MoxonidineRelated Search:

(Trifluoromethoxy)benzene 1-Methylimidazole MOXONIDINE HYDROCHLORIDE,MOXONIDINE HCL 5-METHYLCYTOSINE Pirimiphos-methyl Mestinon Bendazac L-lysine Losartan potassium Fursultiamine Terazosin Lovastatin 4-chloro-6-methoxy-2-methyl-N-(4,4,5,5-tetradeuterio-1H-imidazol-2-yl)pyrimidin-5-amine 5-Amino-4,6-dichloro-2-methylpyrimidine 4-chloro-6-methoxy-2-methylpyrimidin-5-amine 4-Chloro-6-methoxypyrimidine Imidazole Pyrimidine 6-Chloropyrimidin-4(3H)-one

MOXONIDINE

MOXONIDINE HCL

4-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamin

bdf5895

be5895

BDF-5895 HCL

4-CHLORO-6-METHOXY-2-METHYL-5-(2-IMIDAZOLIN-2-YL)AMINOPYRIMIDINE HCL

4-CHLORO-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-6-METHOXY-2-METHYL-5-PYRIMIDINAMINE HYDROCHLORIDE

Moxonidin

4-Chloro-5-(2-imidazolin-2-ylamino)-6-methoxy-2-methylpyrimidine

MOXONIDINE/4-CHLORO-N-(4,5-DIHYDRO-1H-2-IMIDAZOLYL)-6-METHOXY-2-METHYL-5-PYRAMINE

4-Chloro-N-(4，5-dihydro-1H-imidaml-2-y1)-6-methoxy-2-methyl-5-pyrimidinamine

Cynt

Physioterls

4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamine

4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methylpyrimidin-5-amine

Norcynt

(4-chloro-6-methoxy-2-methyl-pyrimidin-5-yl)-(4,5-dihydro-1H-imidazol-2-yl)amine

5-Pyrimidinamine, 4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-

2-(6-Chloro-4-Methoxy-2-MethylpyriMidin-5-ylaMino)-2-iMidazoline

LoMox

NorMoxocin

Nucynt

Physiotens

Moxonidine-d3

4-Chloro-6-methoxy-2-methyl-5-(2-imidazolin-2-yl)aminopyrimidine hydrochloride

4-chloro-N-imidazolidin-2-ylidene-6-methoxy-2-methylpyrimidin-5-amine

Moxonidine &gt

Moxonidine CRS

Moxonidine USP/EP/BP

Moxonidine (BDF5895)

Moxonidine 13CD3Q: What is Moxonidine 13CD3 Q: What is the CAS Number of Moxonidine 13CD3 Q: What is the storage condition of Moxonidine 13CD3

MoxonidineQ: What is Moxonidine Q: What is the CAS Number of Moxonidine Q: What is the storage condition of Moxonidine Q: What are the applications of Moxonidine

75438-57-2

C9H12ClN5O

C9H12Cl5O

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