4,6-Dichloro-2-methylpyrimidine
- Product Name
- 4,6-Dichloro-2-methylpyrimidine
- CAS No.
- 1780-26-3
- Chemical Name
- 4,6-Dichloro-2-methylpyrimidine
- Synonyms
- 6-Dichloro-2-methylpyrimidine;2-METHYL-4,6-DICHLOROPYRIMIDINE;Pyrimidine, 4,6-dichloro-2-methyl-;2-MDCP;BUTTPARK 52\14-70;4,6-Dichloro-2-methy;Dasatinib Impurity 99;Dasatinib EP Impurity-B;4,6-Dicloro-2-methylpyrimidine;4,6-DICHLORO-2-METHYLPYRIMIDINE
- CBNumber
- CB2176132
- Molecular Formula
- C5H4Cl2N2
- Formula Weight
- 163
- MOL File
- 1780-26-3.mol
4,6-Dichloro-2-methylpyrimidine Property
- Melting point:
- 41.5-45.5 °C (lit.)
- Boiling point:
- 210.8±20.0 °C(Predicted)
- Density
- 1.404±0.06 g/cm3(Predicted)
- Flash point:
- 208 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- pka
- -3.84±0.30(Predicted)
- form
- Crystalline Powder or Crystals
- color
- White to off-white
- InChI
- InChI=1S/C5H4Cl2N2/c1-3-8-4(6)2-5(7)9-3/h2H,1H3
- InChIKey
- FIMUTBLUWQGTIJ-UHFFFAOYSA-N
- SMILES
- C1(C)=NC(Cl)=CC(Cl)=N1
- CAS DataBase Reference
- 1780-26-3(CAS DataBase Reference)
Safety
- Hazard Codes
- C,N,Xn
- Risk Statements
- 34-51/53-43-22
- Safety Statements
- 26-36/37/39-45-61-36/37
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 596728
- Product name
- 4,6-Dichloro-2-methylpyrimidine
- Purity
- 98%
- Packaging
- 5g
- Price
- $21.36
- Updated
- 2025/07/31
- Product number
- 596728
- Product name
- 4,6-Dichloro-2-methylpyrimidine
- Purity
- 98%
- Packaging
- 25g
- Price
- $99.5
- Updated
- 2025/07/31
- Product number
- D3558
- Product name
- 4,6-Dichloro-2-methylpyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $30
- Updated
- 2025/07/31
- Product number
- D3558
- Product name
- 4,6-Dichloro-2-methylpyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $120
- Updated
- 2025/07/31
- Product number
- 161620
- Product name
- 4,6-Dichloro-2-methylpyrimidine
- Packaging
- 5g
- Price
- $403
- Updated
- 2021/12/16
4,6-Dichloro-2-methylpyrimidine Chemical Properties,Usage,Production
Chemical Properties
White to off-white solid
Uses
4,6-Dichloro-2-methylpyrimidine, is a versatile building block used for the synthesis of more complex pharmaceutical and biologically active compounds, such as Dasatinib (D290002), and its derivatives.
Synthesis
1194-22-5
1780-26-3
General procedure for the synthesis of 4,6-dichloro-2-methylpyrimidine from 6-hydroxy-2-methylpyrimidin-4-one: 4,6-dihydroxy-2-methylpyrimidine (5.0 g, 0.04 mol) was added to a mixed solution of thionyl chloride (18.9 g, 0.16 mol) with acetonitrile. The reaction mixture was stirred at 80 °C for 3 h and the completion of the reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, excess thionyl chloride was removed by distillation under reduced pressure and the residue was slowly poured into 50 g of ice water. The precipitated solid was filtered and purified by column chromatography to give 6.1 g (yield: 94%) of 4,6-dichloro-2-methylpyrimidine as a white solid.
References
[1] Tetrahedron Letters, 2009, vol. 50, # 41, p. 5729 - 5732
[2] Patent: CN106478519, 2017, A. Location in patent: Paragraph 0020-0023; 0030-0032; 0038-0040; 0049-0052
[3] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 11, p. 2969 - 2973
[4] Tetrahedron, 2006, vol. 62, # 10, p. 2304 - 2312
[5] Patent: WO2004/46133, 2004, A1. Location in patent: Page 40-41
4,6-Dichloro-2-methylpyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4,6-Dichloro-2-methylpyrimidine manufacturers
- Product
- 4,6-Dichloro-2-methylpyrimidine 1780-26-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-19
- Product
- 4,6-Dichloro-2-methylpyrimidine 1780-26-3
- Price
- US $25.00/ASSAYS
- Min. Order
- 100ASSAYS
- Purity
- 99.5%
- Supply Ability
- 100 mt
- Release date
- 2025-03-10
- Product
- 4,6-Dichloro-2-methylpyrimidine 1780-26-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-10