4,6-dichloro-2-propylthiopyrimidine-5-amine

Product Name: 4,6-dichloro-2-propylthiopyrimidine-5-amine
CAS No.: 145783-15-9
Chemical Name: 4,6-dichloro-2-propylthiopyrimidine-5-amine
Synonyms: 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine;oro-2-propyL;Ticagrelor Impurity U;thiopyrimidine-5-amine;Ticagrelor Impurity 110;Tecagrelor InterMediate 3;Ticagrelor Intermediate ide;2-propylthiopyrimidine-5-amine;6-dichloro-2-propylthiopyrimidine-5-amine;4,6-Dichloro-2-(propylthio)pyriMidin-aMine
CBNumber: CB92487693
Molecular Formula: C7H9Cl2N3S
Formula Weight: 238.14
MOL File: 145783-15-9.mol

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4,6-dichloro-2-propylthiopyrimidine-5-amine Property

Boiling point:: 334.1±37.0 °C(Predicted)
Density: 1.44
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to lump to clear liquid
pka: -3.46±0.12(Predicted)
color: White or colorless to Brown
Water Solubility: 100mg/L at 22℃
InChI: InChI=1S/C7H9Cl2N3S/c1-2-3-13-7-11-5(8)4(10)6(9)12-7/h2-3,10H2,1H3
InChIKey: CJJLJBFJNXMANZ-UHFFFAOYSA-N
SMILES: C1(SCCC)=NC(Cl)=C(N)C(Cl)=N1

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Safety

Safety Statements: 24/25
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2716
Product name: 5-Amino-4,6-dichloro-2-(propylthio)pyrimidine
Purity: >98.0%(GC)
Packaging: 1g
Price: $58
Updated: 2024/03/01

TCI Chemical

Product number: A2716
Product name: 5-Amino-4,6-dichloro-2-(propylthio)pyrimidine
Purity: >98.0%(GC)
Packaging: 5g
Price: $175
Updated: 2024/03/01

BroadPharm

Product number: BP-20662
Product name: 4,6-dichloro-2-(propylthio)pyrimidin-5-amine
Packaging: 100mg
Price: $180
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD16313
Product name: 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine
Packaging: 500g
Price: $235
Updated: 2021/12/16

SynQuest Laboratories

Product number: 7H66-5-72
Product name: 4,6-Dichloro-2-(propylsulfanyl)pyrimidin-5-amine
Purity: 97.0%
Packaging: 100g
Price: $260
Updated: 2021/12/16

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4,6-dichloro-2-propylthiopyrimidine-5-amine Chemical Properties,Usage,Production

Description

4,6-dichloro-2-propylthiopyrimidine-5-amine is a pharmaceutical intermediate used in the preparation of Ticagrelor, which belongs to a class of drugs called antiplatelet agents. It works by preventing platelets (a type of blood cell) from aggregating and forming clots that can lead to heart attacks or strokes.

Chemical Properties

Light pink to dark brown liquid or semi solid

Uses

Intermediate in the preparation of Ticagrelor (T437700) and reversible P2Y12 receptor antagonists.

Synthesis

The synthesis of 4,6-dichloro-2-propylthiopyrimidine-5-amine is as follows：tert-Butyl methyl ether (370 g) was placed under nitrogen in a 1 L stainless steel autoclave equipped with a temperature-controlled jacket, an Ekato InterMIG stirrer, an internal temperature sensor and a dip pipe, and 4,6-dichloro-5-nitro-2-propylsulfanyl-pyrimidine (94.5 g, 0.35 mol) was added and dissolved at a stirring rate of 200 min-1. The catalyst suspension was prepared and transferred into the autoclave as described in the preceding example. The autoclave was sealed and the stirring rate was increased to 600 min-1 while the autoclave was purged four times with nitrogen. Subsequently, hydrogen gas feed via the dip pipe at a constant flow rate (pmax=10 bar) as well as a heating-up ramp (45 K/h) from 20° C. to 65° C. were started in parallel, while stirring at 600 min-1. The progress of the exothermic reaction was followed by recording the hydrogen uptake as well as the internal and jacket temperature curve. Upon completion of the hydrogen uptake (ca. 1.1 mol or 3 molar equivalents) after about 4 h, stirring of the reaction mixture was continued for an additional 3 hours at 65° C. After unloading the autoclave (the reactor was cooled down to 20° C., the hydrogen pressure was released and the reactor purged four times with nitrogen), the catalyst was filtered off. The autoclave as well as the filter cake (catalyst) were washed with tent-butyl methyl ether (185 g). The organic phases were combined and the water layer separated. An IPC-sample was taken to analyze the product mixture. The conversion was found to be quantitative with no nitroso or hydroxylamine intermediate being detectable.

4,6-dichloro-2-propylthiopyrimidine-5-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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4,6-dichloro-2-propylthiopyrimidine-5-amine Suppliers

Americas 1 Canada 1 China 455 Europe 1 Germany 1 India 37 Japan 1 Spain 1 United Kingdom 2 United States 11 Global 511

Hangzhou XunDa Bio-Technology Co., Ltd.

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J & K SCIENTIFIC LTD.

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Chembest Research Laboratories Limited

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View Lastest Price from 4,6-dichloro-2-propylthiopyrimidine-5-amine manufacturers

Shanghai Qianyi New Material Co., Ltd.

Product: 4,6-dichloro-2-propylthiopyriMidine-5-aMine 145783-15-9
Price: US $100.00-500.00/kg
Min. Order: 1000kg
Purity: 99%
Supply Ability: 10ton
Release date: 2023-11-28

Hangzhou ICH Biofarm Co., Ltd

Product: 4,6-dichloro-2-propylthiopyrimidine-5-amine 145783-15-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500KG
Release date: 2023-07-06

Zhuhai Hairuide Bioscience and Technology Co., Ltd

Product: 4,6-dichloro-2-propylthiopyrimidine-5-amine 145783-15-9
Price: US $0.00/KG Ton
Min. Order: 1KG Ton
Purity: 98%+
Supply Ability: 2 tons/month
Release date: 2022-10-10

145783-15-9, 4,6-dichloro-2-propylthiopyrimidine-5-amineRelated Search:

N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine TICAGRELOR 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione Canagliflozin Ticagrelor Sulfone Tetrahydro-2,2-dimethyl-4,7-methano-6H-1,3-dioxolo[4,5-d][1,2]oxazine-6-carboxylic acid phenylmethyl ester 2-((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)ethanol L-tataric acid 4,6-DICHLORO-5-NITRO-2-PROPYLTHIOPYRIMIDINE (3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate 1-Acetyladamantane Intermediate (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine. HCl Ethanol, 2-[[(3aR,4S,6R,6aS)-6-[[5-aMino-6-chloro-2-(propylthio)-4-pyriMidinyl]aMino]tetrahydro-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]- ethyCyclopropanamine, 2-(3,4-difluorophenyl)-, (1R,2S)- (REACH) (1R,2R)-2-(3,4-difluorophenyl)cyclopropane carboxaMide (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine CarbaMicacid,N-[(3aS,4R,6S,6aR)-tetrahydro-6-hydroxy-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-yl]-,phenylMethyl ester

4,6-dichloro-2-propylthiopyrimidine-5-amine

4,6-dichloro-2-(propylthio)-5-PyriMidinaMine

4,6-Dichloro-2-(propylthio)pyrimidin-5-amine

Tecagrelor InterMediate 3

5-PyriMidinaMine, 4,6-dichloro-2-(propylthio)-

4,6-dichloro-2-(propylsulfanyl)-5-pyriMidinaMine

Ticagrelor Impurity 110

4,6-Dichloro-5-amino-2-propylthiopyrimidine

4,6-dichloro-2-(propylsulfanyl)pyriMidin-5-aMine

4,6-Dichloro-2-propylsulfanyl-pyriMidin-5-ylaMine

4,6-Dichloro-2-(propylthio)pyriMidin-aMine

5-Amino-4,6-dichloro-2-(propylthio)pyrimidine

4,6-DICHLORO-2-(PROPYLTHIO) PYRIMDIN-5-AMINE

Ticagrelor Impurity U

5-Amino-4,6-dichloro-2-(propylthio)pyrimidine&gt

2-propylthiopyrimidine-5-amine

oro-2-propyL

thiopyrimidine-5-amine

4,6-dichloro-2-propylthiopyrimidine-5-amine ISO 9001：2015 REACH

1-Acetyladamantane Intermediate，4,6-dichloro-2-propylthiopyrimidine-5- amine

6-dichloro-2-propylthiopyrimidine-5-amine

4, 6-dichloro-2-propyl thio-5-aminopyrimidine

Ticagrelor Intermediate ide

4,6-Dichloro-2-(propylthio)pyrimidin-5-amine? (Ticagrelor Impurity)

4, 6-dichloro-2 -(propylthionyl) -5-aminopyrimidine

4, 6-dichlor〇-2-propylthiopyrimidine-5- amine

4,6-Dichloro-2-(Propylthio) pyrimidin-5-amine (TDP)

4,6-Dichloro-2-(propylthio)-pyrimidin-5-ylamine

4,6 dichloro-5amine - 2 - (propylthio) pyrimidine

Ticagrelor Intermediates4,6-Dichloro-2-propylsulfanyl-pyrimidin-5-ylamine

5-Amino-4,6-dichloro-2- (propylthio)pyrimidin-

4,6-dichloro-2-propylthio-pyrimidine-5-amin

145783-15-9

1145783-15-9

C7H9Cl2N3S

Intermediate of Ticagrelor

bc0001

145783-15-9