ChemicalBook > CAS DataBase List > (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate

(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate

Product Name
(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate
CAS No.
376608-71-8
Chemical Name
(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate
Synonyms
(1R,2S)-2-(3,4-difluorophenyl)cyclopropan-1-amine;(1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine (R)-2-hydroxy-2-phenylacetate;(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanaminium (2R)-hydroxy(phenyl)ethanoate;(1R,2S)-2-(3,4-difluorophenyl)cyclopropan-1-amine (R)-2-hydroxy-2-phenylacetate;(1R,2R)-2-(3,4-difluorophenyl)cyclopropanamine(S)-(carboxylato(phenyl)methyl)holmium;(1R 2S)-2-(3 4- DIFLUOROPHENYL) CYCLOP ROPANAMINIUM (2R)- HYDROXY(PHENYL) ETHAN OATE MANDELIC ACID SALT;EX-7182;2S)-2-(3;Ticagrelor int4;)ethanoate, 98%
CBNumber
CB62535571
Molecular Formula
C17H17F2NO3
Formula Weight
321.32
MOL File
376608-71-8.mol
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(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate Property

storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
InChI
InChI=1/C9H9F2N.C8H8O3/c10-7-2-1-5(3-8(7)11)6-4-9(6)12;9-7(8(10)11)6-4-2-1-3-5-6/h1-3,6,9H,4,12H2;1-5,7,9H,(H,10,11)/t6-,9+;7-/s3
InChIKey
GUESUQPLVFMJIT-RUKVIUEPNA-N
SMILES
[C@H](C1C=CC=CC=1)(O)C(=O)O.N[C@@H]1C[C@H]1C1C=CC(F)=C(F)C=1 |&1:0,12,14,r|
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Safety

Safety Statements 
24/25
HS Code 
29181990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
Z3448
Product name
trans-(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanaminium(2R)-2-hydroxy-2-phenylethanoate
Packaging
1g
Price
$13
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD16312
Product name
(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate
Packaging
10g
Price
$50
Updated
2021/12/16
SynQuest Laboratories
Product number
4622-3-00
Product name
(1R,2S)-2-(3,4-Difluorophenyl)cyclopropan-1-ammonium (2R)-2-hydroxy-2-phenylacetate
Purity
97.0%
Packaging
250mg
Price
$55
Updated
2021/12/16
SynQuest Laboratories
Product number
4622-3-00
Product name
(1R,2S)-2-(3,4-Difluorophenyl)cyclopropan-1-ammonium (2R)-2-hydroxy-2-phenylacetate
Purity
97.0%
Packaging
1g
Price
$85
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD16312
Product name
(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate
Packaging
25g
Price
$100
Updated
2021/12/16
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(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate Chemical Properties,Usage,Production

Description

(1R, 2R)-2-(3, 4-difluorophenyl) cyclopropanamine(S)-(carboxylato(phenyl)methyl) holmium is a useful pharmacological intermediate. It is utilized as an intermediate of trcagrelor, which is a platelet aggregation inhibitor used for prevention of thrombotic events occurring in people with acute coronary syndrome or myocardial infarction.

Chemical Properties

White to off-white powder

Uses

(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine is an intermediate in the preparation of orally active reversible P2Y12 receptor antagonists for the prevention of thrombosis.

References

http://www.tradekorea.com/product/detail/P483269/Ticagrelor-intermediates---CAS-376608-71-8.html
https://en.wikipedia.org/wiki/Ticagrelor

(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate Preparation Products And Raw materials

Raw materials

Preparation Products

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(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate Suppliers

Canada 1 China 371 India 8 United Kingdom 1 United States 9 Global 390
Jiangsu Vcare PharmaTech Co., Ltd.
Tel
025-58741518 17366379912
Fax
+86-25-58744115
Email
sales@vcarepharmatech.com
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China
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Hangzhou XunDa Bio-Technology Co., Ltd.
Tel
0571-86932585
Fax
0571-86932585
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xuandasales@163.com
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China
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Chem-Stone Co.,Ltd.
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020-82185713
Fax
020-82185696
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sales@chem-stone.com
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China
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Anhui nuoquan pharmaceutical co. LTD
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0556-5032870 15705561919
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0556-5032869
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sujuan.mei@nuoquanpharm.com
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China
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Cangzhou Weizhidamei Pharmaceutical Co., Ltd.
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0317-5489888 13426038769
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0317-5486999
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askmryu@163.com
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China
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Shanghai Sagachem Co., Ltd.
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021-68404722 13816115801
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raochenaone@126.com
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China
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Shandong Shenganbei New Energy Co. , Ltd. . Nanjing branch
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18914494296
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sab202211@163.com
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China
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Lianyungang Guanxin Pharmaceutical Technology Co., Ltd
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0518-85772786 13382952762
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sales@grandshinetech.com
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China
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Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
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China
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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
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jkinfo@jkchemical.com
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View Lastest Price from (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate manufacturers

Jinan Finer Chemical Co., Ltd
Product
(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanaminium (2R)-hydroxy(phenyl)ethanoate 376608-71-8
Price
US $0.00/Kg/Drum
Min. Order
1g
Purity
99%
Supply Ability
50mt/year
Release date
2021-06-08
Weijer International Trade (Hebei) Co., Ltd.
Product
(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate 376608-71-8
Price
US $120.00-50.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000T
Release date
2021-09-29
Hebei Mojin Biotechnology Co., Ltd
Product
: (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate 376608-71-8
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
20ton
Release date
2021-10-09

376608-71-8, (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoateRelated Search:

trans-2-(3,4-difluorophenyl) cyclopropanecarboxylic acid ledipasvir interMediate (S)-1-[(R)-2-(DI-TERT.-BUTYLPHOSPHINO)FERROCENYL]ETHYLBIS(2-METHYLPHENYL)PHOSPHI (1R,2R)-(-)-1,2-Diaminocyclohexane (3S)-N-Boc-2-azabicyclo[2.2.1]heptane-3-carboxylic acid (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride TICAGRELOR 2-((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)ethanol L-tataric acid 4,6-dichloro-2-propylthiopyrimidine-5-amine 4,6-DICHLORO-5-NITRO-2-PROPYLTHIOPYRIMIDINE (3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol 1-Acetyladamantane Intermediate (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine. HCl Ethanol, 2-[[(3aR,4S,6R,6aS)-6-[[5-aMino-6-chloro-2-(propylthio)-4-pyriMidinyl]aMino]tetrahydro-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]- ethyCyclopropanamine, 2-(3,4-difluorophenyl)-, (1R,2S)- (REACH) (1R,2R)-2-(3,4-difluorophenyl)cyclopropane carboxaMide (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine CarbaMicacid,N-[(3aS,4R,6S,6aR)-tetrahydro-6-hydroxy-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-yl]-,phenylMethyl ester

  • (1R,2R)-2-(3,4-difluorophenyl)cyclopropanamine(S)-(carboxylato(phenyl)methyl)holmium
  • (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanaMine (2R)-Hydroxy(phenyl)ethanoate
  • (αR)-α-Hydroxybenzeneacetic Acid coMpd. with (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanaMine
  • trans-(1R,2S)-2-(2,3-difluorophenyl)cyclopropylaMine Mandelat
  • (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanaminium (2R)-hydroxy(phenyl)ethanoate
  • (alphaR)-alpha-Hydroxybenzeneacetic acid compd. with (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine
  • (αR)-(1R,2S)-α-hydroxy-Benzeneacetic acid-coMpd.with 2-(3,4-difluorophenyl)cyclopropanaMine(1:1)
  • Ticagrelor InterMediate 4
  • EX-7182
  • (1R-2R)-2-(3,4-diflrorophenyl)cyclopropanamine
  • (1R,2S)-2-(3,4-Difluorophenyl) cyclopropylamine D-Mandelate
  • (1R,2S)-2-(3,4-difluorophenyl)cyclopropan-1-amine
  • (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanaminium
  • (1<i>R</i>,2<i>S</i>)-2-(3,4-Difluorophenyl)cyclopropanamine (2<i>R</i>)-Hydroxy(phenyl)ethanoate
  • Ticagrelor Intermediate3
  • (1S,2R)-2-(3,4-difluorophenyl)cyclopropan-1-amine (R)-2-hydroxy-2-phenylacetate
  • Benzeneacetic acid, α-hydroxy-, (αR)-(1R,2S)-coMpd. with 2-(3,4-difluorophenyl)cyclopropanaMine (1:1)
  • (1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine (R)-2-hydroxy-2-phenylacetate
  • (1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine (R)-2-hydroxy-2-phenylacetate(1:1)
  • (1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine with (R)-(-)-Mandelic acid (1:1)
  • Benzeneaceticacid,a-hydroxy-,(R)-(1R,2S)-coMpd.with2-(3,4-difluorophenyl)cyclopropanaMine(1:1)
  • (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanaMiniuM(2R)-hydroxy(phenyl)
  • (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanaMiniuM (2
  • (1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine (S)-2-hydroxy-2-phenylacetate
  • (1R,2S)-2-(3,4-dimethylphenyl)cyclopropanamine (R)-2-hydroxy-2-phenylacetate
  • (aR)-a-Hydroxy-benzeneacetic acid compd. with (1R,2S)-2-(3,4-difluorophenyl) cyclopropanamine (1:1)
  • (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate 376608-71-8
  • (1R 2S)-2-(3 4-DIFUOROPHENYL)CYCLOPROPAN AMINIUM(2R)-HYDROXY(PHENYL)ETHANOATE
  • Ticagrelor int4
  • (1R,2S)-2-(3,4-Difluorophenyl)cyclopropan-1-ammonium (2R)-2-hydroxy-2-phenylacetate
  • (1R,2S)-2-(3,4-difluorophenyl)cyclopropan-1-amine (R)-2-hydroxy-2-phenylacetate
  • (1R,2S)-2-(3,4-Difluorophenyl) cyclopropanaminium (2R)-hydroxy(phenyl)ethanoat
  • Trans-(1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine mandelate
  • (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (R)-2-hydroxy-2-phenylacetic acid
  • (1S,2R)-2-(3,4- difluorophenyl)cyclopropan-1-amine hydrochloride
  • (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanaMine (2R)-Hydroxy(phenyl)etha
  • (1R,2S)-2-(3,4-Difluorophenyl)-cyclopropan-1-amine (2R)-2-hydroxy-2-phenylacetic acid
  • trans-(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanaminium (2R)-2-hydroxy-2-phenylethanoate
  • (1R,2S)-2-(3,4-DifL
  • )ethanoate, 98%
  • opropanaminium (2R)-hydroxy(phenyL
  • Ticagrelor Related Compound 107
  • (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate ISO 9001：2015 REACH
  • 1-Acetyladamantane Intermediate，(1R,2S)-2-(3,4- Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate
  • 2S)-2-(3
  • 4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate
  • Ticagrelor side chain 2 mandelate
  • carboxylato(phenyl) methyl)holmium
  • trans-(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine (2R)-2-hydroxy-2-phenylethanoate
  • (1R 2S)-2-(3 4- DIFLUOROPHENYL) CYCLOP ROPANAMINIUM (2R)- HYDROXY(PHENYL) ETHAN OATE MANDELIC ACID SALT
  • (1R,2S)-2-(3,4-DIFLUOROPHENYL)CYCLOPROPANAMINE (2R) -2-HYDROXY-2-PHENYLACETATE
  • (1R,2R)-2-(3,4-difluorophenyl) cyclopropanamine(S)-(carboxyl...
  • Ticagrelor EP Impurity B
  • (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine D-Mandelic acid
  • (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanaminium (2R)-hydroxy(phenyl)ethanoate (Ticagrelor Impurity)
  • Benzeneacetic acid, α-hydroxy-, (αR)-(1R,2S)-compd. with 2-(3,4-difluorophenyl)cyclopropanamine (1:1)
  • 376608-71-8
  • 76608-71-8