(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride

Uses

Product Name: (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride
CAS No.: 866783-13-3
Chemical Name: (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride
Synonyms: Ivabradine Impurity 17 HCl;(1R)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride;(7S)-3,4-Dimethoxy-N-methylbicyclo[4.2.0]octa-1,3,5-triene-7-methanamine hydrochloride;(1S)-4;Ivabradine RC 6 (HCl);Ivebradine impurity 3;Ivabradine Impurity 85;Ivabradine Intermediate;Ivabradine intermediate1;Ivabradine Impurity 7 HCL
CBNumber: CB01455900
Molecular Formula: C12H18ClNO2
Formula Weight: 243.73
MOL File: 866783-13-3.mol

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(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride Property

Melting point:: >216°C (dec.)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly)
form: Solid
color: White to Off-White
InChI: InChI=1/C12H17NO2.ClH/c1-13-7-9-4-8-5-11(14-2)12(15-3)6-10(8)9;/h5-6,9,13H,4,7H2,1-3H3;1H/t9-;/s3
InChIKey: SWSAIQSQSDOONK-OVMXBOEKNA-N
SMILES: COC1=CC2[C@@H](CNC)CC=2C=C1OC.Cl |&1:5,r|
CAS DataBase Reference: 866783-13-3(CAS DataBase Reference)

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Safety

HS Code: 29214990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D461760
Product name: (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutaneHydrochloride
Packaging: 250mg
Price: $110
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD150184
Product name: (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutaneHydrochloride
Packaging: 100mg
Price: $50
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD150184
Product name: (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutaneHydrochloride
Packaging: 250mg
Price: $80
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD150184
Product name: (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutaneHydrochloride
Packaging: 500mg
Price: $125
Updated: 2021/12/16

AK Scientific

Product number: X0048
Product name: (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutanehydrochloride
Packaging: 250mg
Price: $130
Updated: 2021/12/16

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(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride Chemical Properties,Usage,Production

Uses

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride is an intermediate used in preparation of Ivabradine (I940500) which is a selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node.

Uses

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane is an intermediate used in preparation of Ivabradine (I940500) which is a selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node.

Synthesis

866783-12-2

866783-13-3

The general procedure for the synthesis of (1S)-4,5-dimethoxy-1-methylaminomethyl-benzocyclobutane hydrochloride from (S)-1-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)-N-methylmethylamine is as follows: (1S)-4,5-dimethoxy-1-methylaminomethyl-benzocyclobutane hydrochloride, which was obtained from the previous step, was was dissolved in a solvent mixture of ethyl acetate (20 mL) and ethanol (5 mL) and stirred at 20 °C. Subsequently, hydrogen chloride gas was passed into the reaction solution and stirring was continued at 15 °C - 20 °C for 1 hour until the reaction solution became turbid. After completion of the reaction, the reaction mixture was washed with a mixed solvent of ethyl acetate/ethanol (4:1, v/v) and dried to afford (1S)-4,5-dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride (2.38 g, 95% yield).

References

[1] Patent: CN104557573, 2018, B. Location in patent: Paragraph 0109; 0116; 0121; 0122
[2] Patent: US2005/261376, 2005, A1. Location in patent: Page/Page column 3

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride Suppliers

China 262 India 11 United Kingdom 2 United States 6 Global 281

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View Lastest Price from (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride 866783-13-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 500kg/M
Release date: 2023-09-06

Hangzhou ICH Biofarm Co., Ltd

Product: (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride 866783-13-3
Price: US $0.00-0.00/kg
Min. Order: 0.1kg
Purity: 99.0%min
Supply Ability: 200kg
Release date: 2023-06-09

Weijer International Trade (Hebei) Co., Ltd.

Product: (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride 866783-13-3
Price: US $13.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 tons
Release date: 2021-10-08

866783-13-3, (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochlorideRelated Search:

Idarubicin hydrochloride Dimethylamine hydrochloride 4-AMINOAZOBENZENE HYDROCHLORIDE 4-Dimethylaminobenzaldehyde Basic Violet 1 Methyl acrylate Tribenuron methyl Methyl salicylate Methanol D-Glucosamine hydrochloride Kresoxim-methyl Topotecan hydrochloride Methylparaben (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one Voriconazole Dimethoxymethane Aminoguanidine hydrochloride Irinotecan hydrochloride

(1S)-4,5-Dimethoxy-1-(Methylaminomethyl)-Benzocyclobutane Hcl

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride

(7S)-3,4-Dimethoxy-N-methylbicyclo[4.2.0]octa-1,3,5-triene-7-methanamine hydrochloride

(1S)-4,5-Dimethoxy-1-(methylaminoethyl)benzocyclobutane HCl

(S)-N-[(4,5-diMethoxybenzocyclobut-1-yl)Methyl ]-N-MethylaMine h

(S)-(4,5-diMethoxy-1,2-dihydrocyclobutabenzen-1-yl)MethanaMine

3,4-diMethoxy-N-Methyl-bicyclo[4.2.0]octa-1,3,5-triene-7-MethanaMine hydrochloride

Bicyclo[4.2.0]octa-1,3,5-triene-7-MethanaMine, 3,4-diMethoxy-N-Methyl-, hydrochloride

(1S)-4,5-DiMethoxy-1-[(MethylaMino)Methyl]benzocyclobutane

(1S)-4,5-DiMethoxy-1-[(MethylaMino)Methyl]benzoc

Ivabradine hydrochloride main chain

Ivabradine intermediate1

(S)-1-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)-N-methylmethanamine hydrochloride

{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amine hydrochloride

(1S)-4

5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride

Ivabradine Impurity 85

Ivabradine related compound

Ivabradine related compound 12

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocycl

3,4-dimethoxy-N-methyl-bicyclo[4.2.0]octa-1,3,5-triene-7-methanamine hydrochloride (For Ivabradine)

[N-[[3,4-DIMETHOXYBICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL] CARBONYL]-N-METHYLAMINE]

S-4,5-Dimethoxy-1-[(methylamino)methyl]benzo cyclobutane hydrochloride

(1R)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochlorideY655

Ivabradine Impurity 17 HCl

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride CAS 866783-13-3

(1S)-4,5-Dimethoxy-1-[(methylamine)methyl]benzocyclobutane HCl

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane h...

Ivabradine RC 6 (HCl)

Ivabradine Impurity 7 HCL

Ivebradine impurity 3

Ivabradine Intermediate

Ivabradine related compound 11(Hydrochloride)

N-[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]-N-methylamine hydrochloride

Ivabradine Amine Hydrochloride

866783-13-3