synthetic
ChemicalBook > CAS DataBase List > (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one

(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one

synthetic
Product Name
(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one
CAS No.
85175-59-3
Chemical Name
(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one
Synonyms
7,8-Dimethoxy-3-(3-chloropropyl)-1,3-dihydro-2H-3-benzazepin-2-one;3-(3-chloropropyl)-7,8-diMethoxy-1H-benzo[d]azepin-2(3H)-one;3-(3-Chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one;-2-one;Ivabradin-1;Ivabradine Impurity c;Ivabradine Impurity f;Ivabradine Impurity 64;Ivabradine intermediate2;(Z)-3-(3-chloropropyl)-7
CBNumber
CB01509856
Molecular Formula
C15H18ClNO3
Formula Weight
295.76
MOL File
85175-59-3.mol
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(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one Property

Melting point:
100-102 °C(Solv: ethanol (64-17-5))
Boiling point:
484.1±45.0 °C(Predicted)
Density 
1.191±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
-1.23±0.20(Predicted)
color 
White to Off-White
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Safety

HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Signal word
Danger
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N-Bromosuccinimide Price

TRC
Product number
C377615
Product name
3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one
Packaging
250mg
Price
$80
Updated
2021/12/16
TRC
Product number
C377615
Product name
3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one
Packaging
5g
Price
$645
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC151724
Product name
3-(3-Chloro-propyl)-7,8-dimethoxy-1,3-dihydro-benzo[d]azepin-2-one
Packaging
50mg
Price
$704
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0037471
Product name
3-(3-CHLORO-PROPYL)-7,8-DIMETHOXY-1,3-DIHYDRO-BENZO[D]AZEPIN-2-ONE
Purity
95.00%
Packaging
5G
Price
$909.56
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC151724
Product name
3-(3-Chloro-propyl)-7,8-dimethoxy-1,3-dihydro-benzo[d]azepin-2-one
Packaging
2mg
Price
$59
Updated
2021/12/16
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(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one Chemical Properties,Usage,Production

synthetic

1.5g (6.8mmol) of 7,8-dimethoxy-1,3-dihydro-2h-3-benzoaza-2-one, 1.5g (9.5mmol) of 1,3-bromochloropropane and 6ml of DMF into a flask, raise the temperature of the mixture to 40 ℃, and add 0.8g of 40% sodium hydroxide (8mmol) solution. The mixture was then heated to 60 ° C and stirred for 2 hours; Add 30 ml of ice water and stir for 1 hour under the cooling of ice water bath. Filter out solid precipitates, wash and dry. The yield of the title compound was 85%.

Description

(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one is the side chain of ivabradine hydrochloride. Ivabradine and its medicinal salts, especially its hydrochloride, have very important pharmacological and therapeutic properties, especially, in slowing down the heart rate. Relating compounds can be used to treat or prevent various clinical myocardial ischemia conditions, such as angina pectoris, myocardial infarction and related rhythm disorders, various pathologies involving rhythm disorders, especially supraventricular rhythm disorders.

Uses

3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one is a reactant used in the synthesis of Zatebradine analogues as potential blockers od hyperpolarization-activated current.

Uses

(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one is an organic compound which can be used as pharmaceutical intermediates.

(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one Suppliers

Jiangsu Yutian pharmaceutical Co.,Ltd.
Tel
0518-86098000 18861350683
Email
lfan@jsytsw.com
Country
China
ProdList
80
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58
Anhui Dexinjia Biopharm Co., Ltd
Tel
0531-82375886 13001715031
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3517280075@qq.com
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China
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295
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58
Chembest Research Laboratories Limited
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021-20908456
Fax
021-58180499
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sales@BioChemBest.com
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China
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6013
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Energy Chemical
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021-021-58432009 400-005-6266
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021-58436166
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sales8178@energy-chemical.com
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China
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956
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0573-85285100
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isenchem@163.com
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China
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Adamas Reagent, Ltd.
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400-6009262 16621234537
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021-64823266
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zhangsn@titansci.com
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China
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14113
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XiaoGan ShenYuan ChemPharm co,ltd
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0712-0712-2580635 15527768850
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1791901229@qq.com
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China
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Syntechem Co.,Ltd
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Fax
E-Mail Inquiry
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info@syntechem.com
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China
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12990
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Tongchuang Pharma(Suzhou). Co., Ltd.
Tel
0512-63263366 18912765016
Fax
0512-6326 3366
Email
tongtf110@sina.com
Country
China
ProdList
1000
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62
Shanghai XueEr Pharmaceutical Technology Co., Ltd
Tel
021-34622192 13917187091
Fax
86-21-34622765
Email
1021708276@qq.com
Country
China
ProdList
86
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View Lastest Price from (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one manufacturers

Wuhan Biocar Pharmacy Co., Ltd.
Product
(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one 85175-59-3
Price
US $9.90-9.90/g
Min. Order
5g
Purity
99.99%HPLC.USP42——Powder、Oil、Pills、Capsules、Tablets,Customiz
Supply Ability
100kg
Release date
2022-10-20
Hebei Yanxi Chemical Co., Ltd.
Product
(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one 85175-59-3
Price
US $50.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10000
Release date
2023-10-23
Weijer International Trade (Hebei) Co., Ltd.
Product
(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H) 85175-59-3
Price
US $39.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5 Tons Per Day
Release date
2021-09-27

85175-59-3, (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-oneRelated Search:


  • (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one
  • ,8-Dimethoxy-3-(3-chloropropyl)-1,3-dihydro-2H-3-benzazepin-2-one
  • 3-(3-Chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one
  • 7,8-Dimethoxy-3-(3-chloropropyl)-1,3-dihydro-2H-3-benzazepin-2-one
  • 3-(3-Chloro-propyl)-7,8-dimethoxy-1,3-dihydro-benzo[d]azepin-2-one
  • 3-(3-chloropropyl)-7,8-diMethoxy-2,3-dihydro-1H-3-benzazepin-2-one
  • 3-(3-Chloropropyl)-7,8-diMethoxy-1H-3-benzazepin-2(3H)-one
  • 2H-3-Benzazepin-2-one, 3-(3-chloropropyl)-1,3-dihydro-7,8-diMethoxy-
  • 3-(3-chloropropyl)-7,8-diMethoxy-1H-benzo[d]azepin-2(3H)-one
  • 3-(3-Chloropropyl)-1,3-dihydro-7,8-diMethoxy-2H-3-
  • 3-(3-chloropropyl)-1,3-dihydro-7,8-diMethoxy-2H-3-Benzazepin-2-one(For Ivabradine)
  • Ivabradine Impurity c
  • Ivabradine Impurity f
  • 3-(3-chloropropyl)-7,8-dimethoxy-1,3-dihydro-2H-benzo[d]azepin-2-one
  • 7,8-Dimethoxy-3-(3-chloropropyl)-1,3-dihydro-2H-3-benzazepin-2-onezazepin-2-one
  • Ivabradine intermediate2
  • 3-(3-Chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-be
  • Ivabradine related compound 4
  • Ivabradin-1
  • (Z)-3-(3-chloropropyl)-7
  • 8-diethyl-1H-benzo[d] azepin-2 (3H)-one
  • Ivabradine Impurity 64
  • 3-(3-chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2-one
  • 7,8-dimethoxy-3- (3-chloropropyl) - 1,3-dihydro-2h-3-benzoazepine-2-one
  • AZEPIN-2 (3H) - (Z) -3- (3-chloropropyl) -7, 8-diethyl-1H - benzo [D] azepin-2 (3H) -
  • (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)
  • 3-(3-CHLOROPROPYL)-7,8-DIMETHOXY- 1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE
  • 8-Demethyl Ivabradine Intermediate(Ivabradine Impurity 8)
  • (S)-3,3'-((((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)azanediyl)bis(propane-3,1-diyl))bis(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one)
  • 3-(3-Chloropropyl)-7,8-dimethoxy-2,3-dihydro-1H-benzoazepin-2-one
  • -2-one
  • 3-(3-Chloropropyl)-7,8-dimetho&#8203
  • xy-1,3-dihydro-2H-3-benzazepin&#8203
  • Ivabradine chloro Impurity 3-(3-chloropropy)-7,8-dimethoxy-1,3-dihydro-2H- benzo[d]azepin-2-one
  • 85175-59-3