(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one

synthetic

Product Name: (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one
CAS No.: 85175-59-3
Chemical Name: (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one
Synonyms: 7,8-Dimethoxy-3-(3-chloropropyl)-1,3-dihydro-2H-3-benzazepin-2-one;3-(3-chloropropyl)-7,8-diMethoxy-1H-benzo[d]azepin-2(3H)-one;3-(3-Chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one;-2-one;Ivabradin-1;Ivabradine Impurity c;Ivabradine Impurity f;Ivabradine Impurity 64;Ivabradine intermediate2;(Z)-3-(3-chloropropyl)-7
CBNumber: CB01509856
Molecular Formula: C15H18ClNO3
Formula Weight: 295.76
MOL File: 85175-59-3.mol

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(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one Property

Melting point:: 100-102 °C(Solv: ethanol (64-17-5))
Boiling point:: 484.1±45.0 °C(Predicted)
Density: 1.191±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: -1.23±0.20(Predicted)
color: White to Off-White
InChI: InChI=1S/C15H18ClNO3/c1-19-13-8-11-4-7-17(6-3-5-16)15(18)10-12(11)9-14(13)20-2/h4,7-9H,3,5-6,10H2,1-2H3
InChIKey: ODEZTTCXWTUAJT-UHFFFAOYSA-N
SMILES: N1(CCCCl)C=CC2=CC(OC)=C(OC)C=C2CC1=O

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Safety

HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: C377615
Product name: 3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one
Packaging: 250mg
Price: $80
Updated: 2021/12/16

TRC

Product number: C377615
Product name: 3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one
Packaging: 5g
Price: $645
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC151724
Product name: 3-(3-Chloro-propyl)-7,8-dimethoxy-1,3-dihydro-benzo[d]azepin-2-one
Packaging: 50mg
Price: $704
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0037471
Product name: 3-(3-CHLORO-PROPYL)-7,8-DIMETHOXY-1,3-DIHYDRO-BENZO[D]AZEPIN-2-ONE
Purity: 95.00%
Packaging: 5G
Price: $909.56
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC151724
Product name: 3-(3-Chloro-propyl)-7,8-dimethoxy-1,3-dihydro-benzo[d]azepin-2-one
Packaging: 2mg
Price: $59
Updated: 2021/12/16

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(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one Chemical Properties,Usage,Production

synthetic

1.5g (6.8mmol) of 7,8-dimethoxy-1,3-dihydro-2h-3-benzoaza-2-one, 1.5g (9.5mmol) of 1,3-bromochloropropane and 6ml of DMF into a flask, raise the temperature of the mixture to 40 ℃, and add 0.8g of 40% sodium hydroxide (8mmol) solution. The mixture was then heated to 60 ° C and stirred for 2 hours; Add 30 ml of ice water and stir for 1 hour under the cooling of ice water bath. Filter out solid precipitates, wash and dry. The yield of the title compound was 85%.

Description

(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one is the side chain of ivabradine hydrochloride. Ivabradine and its medicinal salts, especially its hydrochloride, have very important pharmacological and therapeutic properties, especially, in slowing down the heart rate. Relating compounds can be used to treat or prevent various clinical myocardial ischemia conditions, such as angina pectoris, myocardial infarction and related rhythm disorders, various pathologies involving rhythm disorders, especially supraventricular rhythm disorders.

Uses

3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one is a reactant used in the synthesis of Zatebradine analogues as potential blockers od hyperpolarization-activated current.

Uses

(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one is an organic compound which can be used as pharmaceutical intermediates.

References

[1] Patent: WO2014/102827, 2014, A1. Location in patent: Paragraph 0120
[2] Patent: US4490369, 1984, A
[3] Archiv der Pharmazie, 2010, vol. 343, # 2, p. 114 - 119
[4] Journal of Medicinal Chemistry, 1990, vol. 33, # 5, p. 1496 - 1504
[5] Patent: WO2010/72409, 2010, A1. Location in patent: Page/Page column 18-19

(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one Suppliers

China 200 India 16 United Kingdom 2 United States 6 Global 224

Jiangsu Yutian pharmaceutical Co.,Ltd.

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Anhui Dexinjia Biopharm Co., Ltd

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Syntechem Co.,Ltd

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Shanghai XueEr Pharmaceutical Technology Co., Ltd

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Hangzhou Yuhao Chemical Technology Co., Ltd

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View Lastest Price from (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one 85175-59-3
Price: US $50.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10000
Release date: 2023-10-23

Weijer International Trade (Hebei) Co., Ltd.

Product: (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H) 85175-59-3
Price: US $39.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5 Tons Per Day
Release date: 2021-09-27

Zhuozhou Wenxi import and Export Co., Ltd

Product: 7,8-dimethoxy-3- (3-chloropropyl) - 1,3-dihydro-2h-3-benzoazepine-2-one 85175-59-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

85175-59-3, (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-oneRelated Search:

3-[3-[[[(7S)-3,4-DiMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]Methyl]MethylaMino]propyl]-1,3-dihydro-7,8-diMethoxy-H-3-benzazepin-2-one 7-DeMethyl Ivabradine 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one N-DeMethyl Ivabradine Hydrochloride 3,3'-(propane-1,3-diyl)bis(7,8-dimethoxy-1,3-dihydro-2H-benzo[d]azepin-2-one) C-(3,4-DIMETHOXY-BICYCLO[4.2.0]OCTA-1(6),2,4-TRIEN-7-YL)-METHYLAMINE (3,4-Dimethoxyphenyl)acetic acid Hydroxy Ivabradine N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide 8-DeMethyl Ivabradine 3-(3-Chloropropyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one 3,3'-(propane-1,3-diyl)bis(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one) (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one 4,5-Dimethoxy-1-cyanobenzocyclobutane Ivabradine Impurity 70 1204612-29-2 3,4-dimethoxy-N-methylbenzamide

(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one

,8-Dimethoxy-3-(3-chloropropyl)-1,3-dihydro-2H-3-benzazepin-2-one

3-(3-Chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one

7,8-Dimethoxy-3-(3-chloropropyl)-1,3-dihydro-2H-3-benzazepin-2-one

3-(3-Chloro-propyl)-7,8-dimethoxy-1,3-dihydro-benzo[d]azepin-2-one

3-(3-chloropropyl)-7,8-diMethoxy-2,3-dihydro-1H-3-benzazepin-2-one

3-(3-Chloropropyl)-7,8-diMethoxy-1H-3-benzazepin-2(3H)-one

2H-3-Benzazepin-2-one, 3-(3-chloropropyl)-1,3-dihydro-7,8-diMethoxy-

3-(3-chloropropyl)-7,8-diMethoxy-1H-benzo[d]azepin-2(3H)-one

3-(3-Chloropropyl)-1,3-dihydro-7,8-diMethoxy-2H-3-

3-(3-chloropropyl)-1,3-dihydro-7,8-diMethoxy-2H-3-Benzazepin-2-one(For Ivabradine)

Ivabradine Impurity c

Ivabradine Impurity f

3-(3-chloropropyl)-7,8-dimethoxy-1,3-dihydro-2H-benzo[d]azepin-2-one

7,8-Dimethoxy-3-(3-chloropropyl)-1,3-dihydro-2H-3-benzazepin-2-onezazepin-2-one

Ivabradine intermediate2

3-(3-Chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-be

Ivabradine related compound 4

Ivabradin-1

(Z)-3-(3-chloropropyl)-7

8-diethyl-1H-benzo[d] azepin-2 (3H)-one

Ivabradine Impurity 64

3-(3-chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2-one

7,8-dimethoxy-3- (3-chloropropyl) - 1,3-dihydro-2h-3-benzoazepine-2-one

AZEPIN-2 (3H) - (Z) -3- (3-chloropropyl) -7, 8-diethyl-1H - benzo [D] azepin-2 (3H) -

(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)

3-(3-CHLOROPROPYL)-7,8-DIMETHOXY- 1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE

8-Demethyl Ivabradine Intermediate（Ivabradine Impurity 8）

(S)-3,3'-((((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)azanediyl)bis(propane-3,1-diyl))bis(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one)

3-(3-Chloropropyl)-7,8-dimethoxy-2,3-dihydro-1H-benzoazepin-2-one

-2-one

3-(3-Chloropropyl)-7,8-dimetho&#8203

xy-1,3-dihydro-2H-3-benzazepin&#8203

Ivabradine chloro Impurity 3-(3-chloropropy)-7,8-dimethoxy-1,3-dihydro-2H- benzo[d]azepin-2-one

7,8-dimethoxy-3-(3 -chloropropyl) - 1,3- dihydro-2h -3- benzoazapine-2one

85175-59-3