(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one
synthetic- Product Name
- (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one
- CAS No.
- 85175-59-3
- Chemical Name
- (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one
- Synonyms
- 7,8-Dimethoxy-3-(3-chloropropyl)-1,3-dihydro-2H-3-benzazepin-2-one;3-(3-chloropropyl)-7,8-diMethoxy-1H-benzo[d]azepin-2(3H)-one;3-(3-Chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one;-2-one;Ivabradin-1;Ivabradine Impurity c;Ivabradine Impurity f;Ivabradine Impurity 64;Ivabradine intermediate2;(Z)-3-(3-chloropropyl)-7
- CBNumber
- CB01509856
- Molecular Formula
- C15H18ClNO3
- Formula Weight
- 295.76
- MOL File
- 85175-59-3.mol
(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one Property
- Melting point:
- 100-102 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 484.1±45.0 °C(Predicted)
- Density
- 1.191±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- -1.23±0.20(Predicted)
- color
- White to Off-White
Safety
- HS Code
- 29339900
N-Bromosuccinimide Price
- Product number
- C377615
- Product name
- 3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one
- Packaging
- 250mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- C377615
- Product name
- 3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one
- Packaging
- 5g
- Price
- $645
- Updated
- 2021/12/16
- Product number
- FC151724
- Product name
- 3-(3-Chloro-propyl)-7,8-dimethoxy-1,3-dihydro-benzo[d]azepin-2-one
- Packaging
- 50mg
- Price
- $704
- Updated
- 2021/12/16
- Product number
- HCH0037471
- Product name
- 3-(3-CHLORO-PROPYL)-7,8-DIMETHOXY-1,3-DIHYDRO-BENZO[D]AZEPIN-2-ONE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $909.56
- Updated
- 2021/12/16
- Product number
- FC151724
- Product name
- 3-(3-Chloro-propyl)-7,8-dimethoxy-1,3-dihydro-benzo[d]azepin-2-one
- Packaging
- 2mg
- Price
- $59
- Updated
- 2021/12/16
(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one Chemical Properties,Usage,Production
synthetic
1.5g (6.8mmol) of 7,8-dimethoxy-1,3-dihydro-2h-3-benzoaza-2-one, 1.5g (9.5mmol) of 1,3-bromochloropropane and 6ml of DMF into a flask, raise the temperature of the mixture to 40 ℃, and add 0.8g of 40% sodium hydroxide (8mmol) solution. The mixture was then heated to 60 ° C and stirred for 2 hours; Add 30 ml of ice water and stir for 1 hour under the cooling of ice water bath. Filter out solid precipitates, wash and dry. The yield of the title compound was 85%.
Description
(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one is the side chain of ivabradine hydrochloride. Ivabradine and its medicinal salts, especially its hydrochloride, have very important pharmacological and therapeutic properties, especially, in slowing down the heart rate. Relating compounds can be used to treat or prevent various clinical myocardial ischemia conditions, such as angina pectoris, myocardial infarction and related rhythm disorders, various pathologies involving rhythm disorders, especially supraventricular rhythm disorders.
Uses
3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one is a reactant used in the synthesis of Zatebradine analogues as potential blockers od hyperpolarization-activated current.
Uses
(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one is an organic compound which can be used as pharmaceutical intermediates.
(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one Suppliers
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View Lastest Price from (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one manufacturers
- Product
- (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one 85175-59-3
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2023-10-23
- Product
- (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H) 85175-59-3
- Price
- US $39.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5 Tons Per Day
- Release date
- 2021-09-27
- Product
- 7,8-dimethoxy-3- (3-chloropropyl) - 1,3-dihydro-2h-3-benzoazepine-2-one 85175-59-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10