7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one

Product Name: 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one
CAS No.: 148870-57-9
Chemical Name: 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one
Synonyms: Ivabradine int;Ivabradine Impurity g;7,8-Dimethoxy-3-(3-iodopropyl);7,8-DiMethoxy-3-(3-iodopropyl)-1,3-dihydro-2H;3-(3-Iodopropyl)-7,8-dimethoxy-1H-3-benzazepin-2-one;3-(3-iodopropyl)-7,8-diMethoxy-1H-benzo[d]azepin-2(3H)-one;3-(3-IODOPROPYL)-7,8-DIMETHOXY-1,3-DIHYDRO-2H-3-BENZAPINE-2-ONE;7,8-DiMethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-on;3-(3-iodopropyl)-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2...;7,8-Dimethoxy-3 (3-iodopropyl) -1,3-dihydro-2H-3-benzoazo-2-one
CBNumber: CB72500145
Molecular Formula: C15H18INO3
Formula Weight: 387.21
MOL File: 148870-57-9.mol

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7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one Property

Boiling point:: 504.5±50.0 °C(Predicted)
Density: 1.513
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: -1.23±0.20(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: X4820
Product name: 1,3-Dihydro-3-(3-iodopropyl)-7,8-dimethoxy-2H-3-benzazepin-2-one
Packaging: 10g
Price: $185
Updated: 2021/12/16

Matrix Scientific

Product number: 091119
Product name: 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one
Purity: 95+%
Packaging: 250mg
Price: $265
Updated: 2021/12/16

AK Scientific

Product number: X4820
Product name: 1,3-Dihydro-3-(3-iodopropyl)-7,8-dimethoxy-2H-3-benzazepin-2-one
Packaging: 25g
Price: $320
Updated: 2021/12/16

Matrix Scientific

Product number: 091119
Product name: 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one
Purity: 95+%
Packaging: 1g
Price: $588
Updated: 2021/12/16

Ambeed

Product number: A211518
Product name: 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one
Purity: 95%
Packaging: 250mg
Price: $8
Updated: 2021/12/16

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7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one Chemical Properties,Usage,Production

Synthesis

85175-59-3

148870-57-9

A mixed solution of 7,8-dimethoxy-3-(3-chloropropyl)-1,3-dihydro-2H-3-benzazepin-2-one (50.00 g, 169 mmol) with sodium iodide (32.75 g, 218 mmol) in methyl isobutyl ketone (375 mL) was reacted under argon protection at 117-118 °C with stirring. The reaction process was monitored by high performance liquid chromatography (HPLC). Upon completion of the reaction, the mixture was concentrated under reduced pressure and the residue was diluted with dichloromethane (375 mL) and water (190 mL). The organic phase was separated, washed with water (190 mL) and concentrated again under reduced pressure. The resulting residue was treated with methyl tert-butyl ether (190 mL) and the resulting suspension was cooled to 0 °C. After continuous stirring at 0 °C for 1 h, the solid product was collected by filtration, washed with methyl isobutyl ether (40 mL) and dried at 23 °C/100 mbar for 2 h. The final product was obtained as 60.10 g of light yellow solid product in 92% yield.

References

[1] Patent: WO2014/114341, 2014, A1. Location in patent: Page/Page column 15; 16
[2] Patent: WO2014/102827, 2014, A1. Location in patent: Paragraph 0121
[3] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 17, p. 2351 - 2354
[4] Patent: WO2010/72409, 2010, A1. Location in patent: Page/Page column 19-20
[5] Patent: WO2014/20534, 2014, A1. Location in patent: Page/Page column 13

7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one Suppliers

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Beijing Huikang Boyuan Chemical Tech Co., Ltd

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View Lastest Price from 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one 148870-57-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 100kg
Release date: 2023-09-28

Wuhan Boyuan Import & Export Co., LTD

Product: 7, 8-Dimethoxy-3- (3-iodopropyl) -1, 3-Dihydro-2h-3-Benzazepin-2-One 148870-57-9
Price: US $30.00-15.00/kg
Min. Order: 1kg
Purity: 99.50%
Supply Ability: 20tons
Release date: 2023-03-03

Wuhan Boyuan Import & Export Co., LTD

Product: 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one 148870-57-9
Price: US $80.00-50.00/kg
Min. Order: 1kg
Purity: 99.99%
Supply Ability: 3 tons per week
Release date: 2023-03-23

148870-57-9, 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-oneRelated Search:

ent-Ivabradine Hydrochloride Ivabradine Impurity 1 Hydrochloride Ivabradine 5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMine (3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanamine hydrochloride 3-[3-[[[(7S)-3,4-DiMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]Methyl]MethylaMino]propyl]-1,3-dihydro-7,8-diMethoxy-H-3-benzazepin-2-one 7-DeMethyl Ivabradine N-DeMethyl Ivabradine Hydrochloride 3,3'-(propane-1,3-diyl)bis(7,8-dimethoxy-1,3-dihydro-2H-benzo[d]azepin-2-one) C-(3,4-DIMETHOXY-BICYCLO[4.2.0]OCTA-1(6),2,4-TRIEN-7-YL)-METHYLAMINE (3,4-Dimethoxyphenyl)acetic acid Hydroxy Ivabradine N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide 8-DeMethyl Ivabradine 3-(3-Chloropropyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one 3,3'-(propane-1,3-diyl)bis(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one) (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride

Ivabradine int

7,8-Dimethoxy-3-(3-iodopropyl)

2H-3-Benzazepin-2-one,1,3-dihydro-3-(3-iodopropyl)-7,8-dimethoxy-

3-(3-IODOPROPYL)-7,8-DIMETHOXY-1,3-DIHYDRO-2H-3-BENZAPINE-2-ONE

3-(3-Iodopropyl)-7,8-diMethoxy-1,3-dihydro-2H-3-benzazepin-2-one

7,8-DiMethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-on

1,3-Dihydro-3-(3-iodopropyl)-7,8-dimethoxy-2H-3-benzazepin-2-one

7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one

3-(3-iodopropyl)-7,8-diMethoxy-2,3-dihydro-1H-3-benzazepin-2-one

7,8-DiMethoxy-3-(3-iodopropyl)-1,3-dihydro-2H

3-(3-iodopropyl)-7,8-diMethoxy-1H-benzo[d]azepin-2(3H)-one

Ivabradine Impurity g

7,8-dimethoxy-3- (3-iodopropyl) - 1,3-dihydro-2h-3-benzoazepine-2-one

3-(3-iodopropyl)-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2...

3-(3-Iodopropyl)-7,8-dimethoxy-1H-3-benzazepin-2-one

7,8-Dimethoxy-3 (3-iodopropyl) -1,3-dihydro-2H-3-benzoazo-2-one

Ivabradine Iodo Impurity 6-3-(3-iodopropyl)-7,8-dimethoxy-1,3-dihydro-2H- benzo[d]azepin-2-one

148870-57-9

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