ChemicalBook > CAS DataBase List > 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one

7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one

Product Name
7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one
CAS No.
148870-57-9
Chemical Name
7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one
Synonyms
Ivabradine int;Ivabradine Impurity g;7,8-Dimethoxy-3-(3-iodopropyl);7,8-DiMethoxy-3-(3-iodopropyl)-1,3-dihydro-2H;3-(3-Iodopropyl)-7,8-dimethoxy-1H-3-benzazepin-2-one;3-(3-iodopropyl)-7,8-diMethoxy-1H-benzo[d]azepin-2(3H)-one;3-(3-IODOPROPYL)-7,8-DIMETHOXY-1,3-DIHYDRO-2H-3-BENZAPINE-2-ONE;7,8-DiMethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-on;3-(3-iodopropyl)-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2...;7,8-Dimethoxy-3 (3-iodopropyl) -1,3-dihydro-2H-3-benzoazo-2-one
CBNumber
CB72500145
Molecular Formula
C15H18INO3
Formula Weight
387.21
MOL File
148870-57-9.mol
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7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one Property

Boiling point:
504.5±50.0 °C(Predicted)
Density 
1.513
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
-1.23±0.20(Predicted)
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific
Product number
091119
Product name
7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one
Purity
95+%
Packaging
250mg
Price
$265
Updated
2021/12/16
AK Scientific
Product number
X4820
Product name
1,3-Dihydro-3-(3-iodopropyl)-7,8-dimethoxy-2H-3-benzazepin-2-one
Packaging
25g
Price
$320
Updated
2021/12/16
Matrix Scientific
Product number
091119
Product name
7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one
Purity
95+%
Packaging
1g
Price
$588
Updated
2021/12/16
AK Scientific
Product number
X4820
Product name
1,3-Dihydro-3-(3-iodopropyl)-7,8-dimethoxy-2H-3-benzazepin-2-one
Packaging
10g
Price
$185
Updated
2021/12/16
Alichem
Product number
148870579
Product name
7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one
Packaging
25g
Price
$200
Updated
2021/12/16
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7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one Chemical Properties,Usage,Production

Synthesis

85175-59-3

148870-57-9

A mixed solution of 7,8-dimethoxy-3-(3-chloropropyl)-1,3-dihydro-2H-3-benzazepin-2-one (50.00 g, 169 mmol) with sodium iodide (32.75 g, 218 mmol) in methyl isobutyl ketone (375 mL) was reacted under argon protection at 117-118 °C with stirring. The reaction process was monitored by high performance liquid chromatography (HPLC). Upon completion of the reaction, the mixture was concentrated under reduced pressure and the residue was diluted with dichloromethane (375 mL) and water (190 mL). The organic phase was separated, washed with water (190 mL) and concentrated again under reduced pressure. The resulting residue was treated with methyl tert-butyl ether (190 mL) and the resulting suspension was cooled to 0 °C. After continuous stirring at 0 °C for 1 h, the solid product was collected by filtration, washed with methyl isobutyl ether (40 mL) and dried at 23 °C/100 mbar for 2 h. The final product was obtained as 60.10 g of light yellow solid product in 92% yield.

References

[1] Patent: WO2014/114341, 2014, A1. Location in patent: Page/Page column 15; 16
[2] Patent: WO2014/102827, 2014, A1. Location in patent: Paragraph 0121
[3] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 17, p. 2351 - 2354
[4] Patent: WO2010/72409, 2010, A1. Location in patent: Page/Page column 19-20
[5] Patent: WO2014/20534, 2014, A1. Location in patent: Page/Page column 13

7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one 148870-57-9
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
100kg
Release date
2023-09-28
Wuhan Boyuan Import & Export Co., LTD
Product
7, 8-Dimethoxy-3- (3-iodopropyl) -1, 3-Dihydro-2h-3-Benzazepin-2-One 148870-57-9
Price
US $30.00-15.00/kg
Min. Order
1kg
Purity
99.50%
Supply Ability
20tons
Release date
2023-03-03
Wuhan Boyuan Import & Export Co., LTD
Product
7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one 148870-57-9
Price
US $80.00-50.00/kg
Min. Order
1kg
Purity
99.99%
Supply Ability
3 tons per week
Release date
2023-03-23

148870-57-9, 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-oneRelated Search:

ent-Ivabradine Hydrochloride Ivabradine Impurity 1 Hydrochloride Ivabradine 5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMine (3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanamine hydrochloride 3-[3-[[[(7S)-3,4-DiMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]Methyl]MethylaMino]propyl]-1,3-dihydro-7,8-diMethoxy-H-3-benzazepin-2-one 7-DeMethyl Ivabradine N-DeMethyl Ivabradine Hydrochloride 3,3'-(propane-1,3-diyl)bis(7,8-dimethoxy-1,3-dihydro-2H-benzo[d]azepin-2-one) C-(3,4-DIMETHOXY-BICYCLO[4.2.0]OCTA-1(6),2,4-TRIEN-7-YL)-METHYLAMINE (3,4-Dimethoxyphenyl)acetic acid Hydroxy Ivabradine N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide 8-DeMethyl Ivabradine 3-(3-Chloropropyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one 3,3'-(propane-1,3-diyl)bis(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one) (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride

  • Ivabradine int
  • 7,8-Dimethoxy-3-(3-iodopropyl)
  • 2H-3-Benzazepin-2-one,1,3-dihydro-3-(3-iodopropyl)-7,8-dimethoxy-
  • 3-(3-IODOPROPYL)-7,8-DIMETHOXY-1,3-DIHYDRO-2H-3-BENZAPINE-2-ONE
  • 3-(3-Iodopropyl)-7,8-diMethoxy-1,3-dihydro-2H-3-benzazepin-2-one
  • 7,8-DiMethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-on
  • 1,3-Dihydro-3-(3-iodopropyl)-7,8-dimethoxy-2H-3-benzazepin-2-one
  • 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one
  • 3-(3-iodopropyl)-7,8-diMethoxy-2,3-dihydro-1H-3-benzazepin-2-one
  • 7,8-DiMethoxy-3-(3-iodopropyl)-1,3-dihydro-2H
  • 3-(3-iodopropyl)-7,8-diMethoxy-1H-benzo[d]azepin-2(3H)-one
  • Ivabradine Impurity g
  • 7,8-dimethoxy-3- (3-iodopropyl) - 1,3-dihydro-2h-3-benzoazepine-2-one
  • 3-(3-iodopropyl)-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2...
  • 3-(3-Iodopropyl)-7,8-dimethoxy-1H-3-benzazepin-2-one
  • 7,8-Dimethoxy-3 (3-iodopropyl) -1,3-dihydro-2H-3-benzoazo-2-one
  • Ivabradine Iodo Impurity 6-3-(3-iodopropyl)-7,8-dimethoxy-1,3-dihydro-2H- benzo[d]azepin-2-one
  • 148870-57-9
  • XHL