(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanamine hydrochloride

Product Name: (3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanamine hydrochloride
CAS No.: 35202-55-2
Chemical Name: (3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanamine hydrochloride
Synonyms: Ivabradine Impurity 9 HCl;Ivabradine Impurity 28 HCl;(3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl)methanamine;3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-methanamine Hydrochloride;(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanamine hydrochloride;3,4-Dimethoxy-Bicyclo[4.2.0]octa-1,3,5-triene-7-methanamine hydrochloride (1:1)
CBNumber: CB83052277
Molecular Formula: C11H16ClNO2
Formula Weight: 229.70324
MOL File: 35202-55-2.mol

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(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanamine hydrochloride Property

storage temp.: Sealed in dry,Room Temperature
Appearance: White to light yellow Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Ambeed

Product number: A421582
Product name: (3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanaminehydrochloride
Purity: 97%
Packaging: 100mg
Price: $89
Updated: 2021/12/16

Ambeed

Product number: A421582
Product name: (3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanaminehydrochloride
Purity: 97%
Packaging: 250mg
Price: $135
Updated: 2021/12/16

Crysdot

Product number: CD12080022
Product name: (3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanaminehydrochloride
Purity: 97%
Packaging: 250mg
Price: $291
Updated: 2021/12/16

Ambeed

Product number: A421582
Product name: (3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanaminehydrochloride
Purity: 97%
Packaging: 1g
Price: $335
Updated: 2021/12/16

Chemenu

Product number: CM252425
Product name: (3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanaminehydrochloride
Purity: 95+%
Packaging: 1g
Price: $687
Updated: 2021/12/16

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(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanamine hydrochloride Chemical Properties,Usage,Production

Synthesis

35202-54-1

35202-55-2

General procedure for the synthesis of (3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-dien-7-yl)methanamine hydrochloride from 4,5-dimethoxy-1-cyanobenzocyclobutane: reference to EP 0 534 859 Step 1: Preparation of 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-amine hydrochloride. To a solution of 25 g of 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile dissolved in 250 ml of tetrahydrofuran (THF) at room temperature was added slowly and dropwise 312 ml of borane-THF complex solution with continuous stirring for 12 hours. Subsequently, 200 mL of ethanol was added and stirring was continued for 1 hour. 100 ml of a 3.3 N solution of ethyl ether hydrochloride was added slowly and dropwise. Eventually 27.7 g of the target product was obtained in 90% yield with a melting point of 205°C.

References

[1] Patent: US2014/107334, 2014, A1. Location in patent: Paragraph 0052-0055
[2] Patent: US2014/128598, 2014, A1. Location in patent: Paragraph 0044-0047
[3] Patent: US2014/163220, 2014, A1. Location in patent: Paragraph 0040-0043

(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanamine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanamine hydrochloride Suppliers

China 28 India 3 United States 3 Global 34

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View Lastest Price from (3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanamine hydrochloride manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: (3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanamine hydrochloride 35202-55-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-08-16

35202-55-2, (3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanamine hydrochlorideRelated Search:

Ivabradine Impurity 5 3-(3-hydroxypropyl)-7,8-dimethoxy-1,3-dihydro-2H-benzo[d]azepin-2-one Ivabradine IMpurity 7-DeMethyl Ivabradine 2H-3-Benzazepin-2-one, 3-[3-[[[(7R)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3-dihydro-7,8-dimethoxy-, ethanedioate (1:1) Ivabradine impurity (Br) Ivabradine Impurity 1 Hydrochloride (1S)-4, 5-dimethoxyl-1 -(ethoxycarbonyl aminomethyl) -benzocyclobutane 1616710-52-1 Ivabradine Impurity 1 Hydrochloride INDEX NAME NOT YET ASSIGNED 1204612-29-2 Dehydro Ivabradine Oxalate 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one 4,5-Dimethoxy-1-cyanobenzocyclobutane (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride

(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanamine hydrochloride

(3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl)methanamine

3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-methanamine Hydrochloride

3,4-Dimethoxy-Bicyclo[4.2.0]octa-1,3,5-triene-7-methanamine hydrochloride (1:1)

Ivabradine Impurity 28 HCl

Ivabradine Impurity 9 HCl

35202-55-2