ChemicalBook > CAS DataBase List > 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one

7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one

Product Name
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
CAS No.
73942-87-7
Chemical Name
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
Synonyms
8-Dimethoxy-1;Ivabradine Impurity 13;Ivabradine Impurity 73;Ivabradine Impurity 22;3-dihydro-2H-3-benzazepin-2-one;7,8-diMethoxy-1H-benzo[d]azepin-2(3H)-one;7,8-dimethoxy-1,3-dihydro-1-benzazepin-2-one;7,8-dimethoxy-1,3-dihydro-3-benzazepin-2-one;7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one>1,3-Dihydro-7,8-dimethoxybenzo[d]azepin-2-one
CBNumber
CB71503994
Molecular Formula
C12H13NO3
Formula Weight
219.24
MOL File
73942-87-7.mol
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7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Property

Melting point:
244.0 to 248.0 °C
Boiling point:
455.8±45.0 °C(Predicted)
Density 
1.167
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), DMSO (Slightly)
form 
Solid
pka
13.29±0.20(Predicted)
color 
Off-White to Pale Beige
InChI
InChI=1S/C12H13NO3/c1-15-10-5-8-3-4-13-12(14)7-9(8)6-11(10)16-2/h3-6H,7H2,1-2H3,(H,13,14)
InChIKey
CPNZASIAJKSBBH-UHFFFAOYSA-N
SMILES
N1C=CC2=CC(OC)=C(OC)C=C2CC1=O
LogP
1.23 at 23℃ and pH6.47
Surface tension
71mN/m at 36.9mg/L and 19℃
CAS DataBase Reference
73942-87-7(CAS DataBase Reference)
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Safety

HS Code 
2914390090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
D4824
Product name
7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one
Purity
>98.0%(GC)
Packaging
1g
Price
$82
Updated
2025/07/31
TCI Chemical
Product number
D4824
Product name
7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one
Purity
>98.0%(GC)
Packaging
5g
Price
$325
Updated
2025/07/31
TRC
Product number
D461010
Product name
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
Packaging
1g
Price
$80
Updated
2021/12/16
Chem-Impex
Product number
43244
Product name
7,8-Dimethoxy-1H-benzo[δ]azepin-2(3H)-one,≥98%(GC)
Purity
≥98%(GC)
Packaging
1G
Price
$39.29
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD34115
Product name
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
Packaging
2g
Price
$40
Updated
2021/12/16
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7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Chemical Properties,Usage,Production

Uses

7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is a substituted benzazepinonee derivative used in the preparation of bradycardic agents as well as isoform-selective f-current blockers.

Application

7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is used in the industrial preparation of pharmaceuticals and can be reacted with trifluoroacetic acid to form 3,4-dimethoxyphenylacetic acid.

Definition

ChEBI: 7,8-dimethoxy-1,3-dihydro-3-benzazepin-2-one is a benzazepine.

Synthesis

1.Charge 142.0 g of N-(2,2-dimethoxyethyl)-2-(3,4-dimethoxyphenyl) acetamide, 710 ml of glacial acetic acid and 710 ml of conc. hydrochloric acid in a 3.0 L round bottom flask equipped with mechanical stirrer and thermometer pocket at 25°C.
2.Stir the mixture for 17 hours at 25°C.
3.Monitor the reaction by HPLC (starting material should be less than 4.0%).
4.Pour the reaction mixture on 3.0 kg of crushed ice, if HPLC complies.
5.Stir the mixture for 30 minutes and filter the solid material.
6.Wash the mixture with 1 L of water, suck dry and unload the material.
7.Dry the 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one under vacuum at 55-60°C till the LOD comes to below 0.5%.

References

[1] Patent: WO2010/72409, 2010, A1. Location in patent: Page/Page column 17-18
[2] Journal of Medicinal Chemistry, 1990, vol. 33, # 5, p. 1496 - 1504
[3] Patent: CN104031042, 2017, B. Location in patent: Paragraph 0109; 0110
[4] Patent: US4584293, 1986, A
[5] Patent: US4604389, 1986, A

7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Suppliers

Americas 1 Canada 1 China 248 Europe 1 France 1 Germany 1 India 44 Japan 1 Switzerland 1 United Kingdom 4 United States 10 Global 313
Hangzhou FST Pharmaceutical Co., Ltd
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0571-88938669 18667135863
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Syntechem Co.,Ltd
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View Lastest Price from 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one 73942-87-7
Price
US $50.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10000
Release date
2023-10-20
Hangzhou ICH Biofarm Co., Ltd
Product
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one 73942-87-7
Price
US $0.00-0.00/kg
Min. Order
0.1kg
Purity
99.0%min
Supply Ability
200kg
Release date
2023-06-09
Weijer International Trade (Hebei) Co., Ltd.
Product
New Product 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one 73942-87-7
Price
US $88.00-66.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5 Tons Per Day
Release date
2021-09-26

73942-87-7, 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-oneRelated Search:

Ivabradine Impurity 70 4,5-Dimethoxy-1-cyanobenzocyclobutane (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one 3-(3-Chloropropyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one 1204612-29-2 3,4-dimethoxy-N-methylbenzamide 8-DeMethyl Ivabradine N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide Hydroxy Ivabradine (3,4-Dimethoxyphenyl)acetic acid C-(3,4-DIMETHOXY-BICYCLO[4.2.0]OCTA-1(6),2,4-TRIEN-7-YL)-METHYLAMINE Ivabradine Impurity 49 1132079-01-6 N-DeMethyl Ivabradine Hydrochloride Ivabradine Impurity 1 Hydrochloride 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one 7-DeMethyl Ivabradine

  • Ivabradine Impurity 13
  • 1,3-Dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one
  • 7,8-Dimethoxy-1<i>H</i>-benzo[<i>d</i>]azepin-2(3<i>H</i>)-one
  • 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
  • 2H-3-Benzazepin-2-one,1,3-dihydro-7,8-diMethoxy-
  • 1,3-Dihydro-7,8-dimethoxybenzo[d]azepin-2-one
  • 7,8-diMethoxy-2,3-dihydro-1H-3-benzazepin-2-one
  • 7,8-diMethoxy-1H-benzo[d]azepin-2(3H)-one
  • 7,8-dimethoxy-1, 3-dihydro-2H-benzo[d] azepin-2-one
  • 7,8-diMethoxy -1,3-dihydro-2H-3-Benzazepin-2-one/2H-3-Benzazepin-2-one, 1,3-dihydro-7,8-diMethoxy(For Ivabradine)
  • 7,8-dimethoxy -1,3-dihydro-2H-3-Benzazepin-2-one/2H-3-Benzazepin- 2-one, 1,3-dihydro-7,8-dimethoxy
  • 1,3-Dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one 7,8-dimethoxy-1, 3-dihydro-2H-benzo[d] azepin-2-one
  • 7,8-dimethoxy-1,3-dihydro-1-benzazepin-2-one
  • 3-(3-((((R)-3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-1-hydroxy-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one
  • Ivabradine Impurity 73
  • 3-dihydro-2H-3-benzazepin-2-one
  • 8-Dimethoxy-1
  • 7,8 - Dimethoxy-1,3-Dichloro-2H-3-Benzazepin-2-one
  • Ivabradine Impurity 22
  • 7,8-dimethoxy-1,3-dihydro-3-benzazepin-2-one
  • 7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one&gt
  • 7,8-dimethoxy-1,3-dihydro-2h-3-benzoazepine-2-one
  • 7, 8-dimethoxy-1, 3-dihydro-2H-3-benzoze heptin-2-1, 7-dimethoxy-1, 3-dihydro-2H-3-benzoze heptin-2-1
  • 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one CAS 73942-87-7
  • Hot Sell 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
  • New Product 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
  • 7,8-Dimethoxy-1,3-dihydro-2H-3-benzoazo-2-one
  • 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one , 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
  • 73942-87-7
  • 73492-87-7
  • Aromatics
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  • Intermediates