7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one

ChemicalBook > CAS DataBase List > 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one

7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one

Product Name: 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
CAS No.: 73942-87-7
Chemical Name: 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
Synonyms: 8-Dimethoxy-1;Ivabradine Impurity 13;Ivabradine Impurity 73;Ivabradine Impurity 22;3-dihydro-2H-3-benzazepin-2-one;7,8-diMethoxy-1H-benzo[d]azepin-2(3H)-one;7,8-dimethoxy-1,3-dihydro-1-benzazepin-2-one;7,8-dimethoxy-1,3-dihydro-3-benzazepin-2-one;7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one>1,3-Dihydro-7,8-dimethoxybenzo[d]azepin-2-one
CBNumber: CB71503994
Molecular Formula: C12H13NO3
Formula Weight: 219.24
MOL File: 73942-87-7.mol

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7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Property

Melting point:: 244.0 to 248.0 °C
Boiling point:: 455.8±45.0 °C(Predicted)
Density: 1.167
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), DMSO (Slightly)
form: Solid
pka: 13.29±0.20(Predicted)
color: Off-White to Pale Beige
LogP: 1.23 at 23℃ and pH6.47
Surface tension: 71mN/m at 36.9mg/L and 19℃
CAS DataBase Reference: 73942-87-7(CAS DataBase Reference)

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Safety

HS Code: 2914390090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TCI Chemical

Product number: D4824
Product name: 7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one
Purity: >98.0%(GC)
Packaging: 1g
Price: $72
Updated: 2024/03/01

TCI Chemical

Product number: D4824
Product name: 7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one
Purity: >98.0%(GC)
Packaging: 5g
Price: $285
Updated: 2024/03/01

TRC

Product number: D461010
Product name: 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
Packaging: 1g
Price: $80
Updated: 2021/12/16

Chem-Impex

Product number: 43244
Product name: 7,8-Dimethoxy-1H-benzo[δ]azepin-2(3H)-one,≥98%(GC)
Purity: ≥98%(GC)
Packaging: 1G
Price: $39.29
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD34115
Product name: 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
Packaging: 2g
Price: $40
Updated: 2021/12/16

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7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Chemical Properties,Usage,Production

Uses

7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is a substituted benzazepinonee derivative used in the preparation of bradycardic agents as well as isoform-selective f-current blockers.

Application

7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is used in the industrial preparation of pharmaceuticals and can be reacted with trifluoroacetic acid to form 3,4-dimethoxyphenylacetic acid.

Definition

ChEBI: 7,8-dimethoxy-1,3-dihydro-3-benzazepin-2-one is a benzazepine.

Synthesis

1.Charge 142.0 g of N-(2,2-dimethoxyethyl)-2-(3,4-dimethoxyphenyl) acetamide, 710 ml of glacial acetic acid and 710 ml of conc. hydrochloric acid in a 3.0 L round bottom flask equipped with mechanical stirrer and thermometer pocket at 25°C.
2.Stir the mixture for 17 hours at 25°C.
3.Monitor the reaction by HPLC (starting material should be less than 4.0%).
4.Pour the reaction mixture on 3.0 kg of crushed ice, if HPLC complies.
5.Stir the mixture for 30 minutes and filter the solid material.
6.Wash the mixture with 1 L of water, suck dry and unload the material.
7.Dry the 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one under vacuum at 55-60°C till the LOD comes to below 0.5%.

7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one 73942-87-7
Price: US $50.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10000
Release date: 2023-10-20

Hebei Kingfiner Technology Development Co.Ltd

Product: 7,8-dimethoxy-1,3-dihydro-2h-3-benzoazepine-2-one 73942-87-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG
Release date: 2023-12-18

Hangzhou ICH Biofarm Co., Ltd

Product: 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one 73942-87-7
Price: US $0.00-0.00/kg
Min. Order: 0.1kg
Purity: 99.0%min
Supply Ability: 200kg
Release date: 2023-06-09

73942-87-7, 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-oneRelated Search:

Ivabradine Impurity 70 4,5-Dimethoxy-1-cyanobenzocyclobutane (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one 3-(3-Chloropropyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one 1204612-29-2 3,4-dimethoxy-N-methylbenzamide 8-DeMethyl Ivabradine N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide Hydroxy Ivabradine (3,4-Dimethoxyphenyl)acetic acid C-(3,4-DIMETHOXY-BICYCLO[4.2.0]OCTA-1(6),2,4-TRIEN-7-YL)-METHYLAMINE Ivabradine Impurity 49 1132079-01-6 N-DeMethyl Ivabradine Hydrochloride Ivabradine Impurity 1 Hydrochloride 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one 7-DeMethyl Ivabradine

Ivabradine Impurity 13

1,3-Dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one

7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one

7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one

2H-3-Benzazepin-2-one,1,3-dihydro-7,8-diMethoxy-

1,3-Dihydro-7,8-dimethoxybenzo[d]azepin-2-one

7,8-diMethoxy-2,3-dihydro-1H-3-benzazepin-2-one

7,8-diMethoxy-1H-benzo[d]azepin-2(3H)-one

7,8-dimethoxy-1, 3-dihydro-2H-benzo[d] azepin-2-one

7,8-diMethoxy -1,3-dihydro-2H-3-Benzazepin-2-one/2H-3-Benzazepin-2-one, 1,3-dihydro-7,8-diMethoxy(For Ivabradine)

7,8-dimethoxy -1,3-dihydro-2H-3-Benzazepin-2-one/2H-3-Benzazepin- 2-one, 1,3-dihydro-7,8-dimethoxy

1,3-Dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one 7,8-dimethoxy-1, 3-dihydro-2H-benzo[d] azepin-2-one

7,8-dimethoxy-1,3-dihydro-1-benzazepin-2-one

3-(3-((((R)-3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-1-hydroxy-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one

Ivabradine Impurity 73

3-dihydro-2H-3-benzazepin-2-one

8-Dimethoxy-1

7,8 - Dimethoxy-1,3-Dichloro-2H-3-Benzazepin-2-one

Ivabradine Impurity 22

7,8-dimethoxy-1,3-dihydro-3-benzazepin-2-one

7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one&gt

7,8-dimethoxy-1,3-dihydro-2h-3-benzoazepine-2-one

7, 8-dimethoxy-1, 3-dihydro-2H-3-benzoze heptin-2-1, 7-dimethoxy-1, 3-dihydro-2H-3-benzoze heptin-2-1

7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one CAS 73942-87-7

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