ChemicalBook > CAS DataBase List > 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
- Product Name
- 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
- CAS No.
- 73942-87-7
- Chemical Name
- 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
- Synonyms
- 8-Dimethoxy-1;Ivabradine Impurity 13;Ivabradine Impurity 73;Ivabradine Impurity 22;3-dihydro-2H-3-benzazepin-2-one;7,8-diMethoxy-1H-benzo[d]azepin-2(3H)-one;7,8-dimethoxy-1,3-dihydro-1-benzazepin-2-one;7,8-dimethoxy-1,3-dihydro-3-benzazepin-2-one;7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one>1,3-Dihydro-7,8-dimethoxybenzo[d]azepin-2-one
- CBNumber
- CB71503994
- Molecular Formula
- C12H13NO3
- Formula Weight
- 219.24
- MOL File
- 73942-87-7.mol
More
Less
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Property
- Melting point:
- 244.0 to 248.0 °C
- Boiling point:
- 455.8±45.0 °C(Predicted)
- Density
- 1.167
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), DMSO (Slightly)
- form
- Solid
- pka
- 13.29±0.20(Predicted)
- color
- Off-White to Pale Beige
- LogP
- 1.23 at 23℃ and pH6.47
- Surface tension
- 71mN/m at 36.9mg/L and 19℃
- CAS DataBase Reference
- 73942-87-7(CAS DataBase Reference)
More
Less
Safety
- HS Code
- 2914390090
More
Less
N-Bromosuccinimide Price
TCI Chemical
- Product number
- D4824
- Product name
- 7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $72
- Updated
- 2024/03/01
TCI Chemical
- Product number
- D4824
- Product name
- 7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $285
- Updated
- 2024/03/01
TRC
- Product number
- D461010
- Product name
- 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
AK Scientific
- Product number
- J97545
- Product name
- 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
- Packaging
- 5g
- Price
- $77
- Updated
- 2021/12/16
Chem-Impex
- Product number
- 43244
- Product name
- 7,8-Dimethoxy-1H-benzo[δ]azepin-2(3H)-one,≥98%(GC)
- Purity
- ≥98%(GC)
- Packaging
- 1G
- Price
- $39.29
- Updated
- 2021/12/16
More
Less
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Chemical Properties,Usage,Production
Uses
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is a substituted benzazepinonee derivative used in the preparation of bradycardic agents as well as isoform-selective f-current blockers.
Application
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is used in the industrial preparation of pharmaceuticals and can be reacted with trifluoroacetic acid to form 3,4-dimethoxyphenylacetic acid.
Definition
ChEBI: 7,8-dimethoxy-1,3-dihydro-3-benzazepin-2-one is a benzazepine.
Synthesis
1.Charge 142.0 g of N-(2,2-dimethoxyethyl)-2-(3,4-dimethoxyphenyl) acetamide, 710 ml of glacial acetic acid and 710 ml of conc. hydrochloric acid in a 3.0 L round bottom flask equipped with mechanical stirrer and thermometer pocket at 25°C.
2.Stir the mixture for 17 hours at 25°C.
3.Monitor the reaction by HPLC (starting material should be less than 4.0%).
4.Pour the reaction mixture on 3.0 kg of crushed ice, if HPLC complies.
5.Stir the mixture for 30 minutes and filter the solid material.
6.Wash the mixture with 1 L of water, suck dry and unload the material.
7.Dry the 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one under vacuum at 55-60°C till the LOD comes to below 0.5%.
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
More
Less
View Lastest Price from 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one manufacturers
Hebei Yanxi Chemical Co., Ltd.
- Product
- 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one 73942-87-7
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2023-10-20
Hebei Kingfiner Technology Development Co.Ltd
- Product
- 7,8-dimethoxy-1,3-dihydro-2h-3-benzoazepine-2-one 73942-87-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG
- Release date
- 2023-12-18
Hangzhou ICH Biofarm Co., Ltd
- Product
- 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one 73942-87-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.1kg
- Purity
- 99.0%min
- Supply Ability
- 200kg
- Release date
- 2023-06-09
73942-87-7, 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-oneRelated Search:
Ivabradine Impurity 70
4,5-Dimethoxy-1-cyanobenzocyclobutane
(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride
(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one
3-(3-Chloropropyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one
1204612-29-2
3,4-dimethoxy-N-methylbenzamide
8-DeMethyl Ivabradine
N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide
Hydroxy Ivabradine
(3,4-Dimethoxyphenyl)acetic acid
C-(3,4-DIMETHOXY-BICYCLO[4.2.0]OCTA-1(6),2,4-TRIEN-7-YL)-METHYLAMINE
Ivabradine Impurity 49
1132079-01-6
N-DeMethyl Ivabradine Hydrochloride
Ivabradine Impurity 1 Hydrochloride
7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one
7-DeMethyl Ivabradine