ChemicalBook > CAS DataBase List > (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one
(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one
synthetic- Product Name
- (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one
- CAS No.
- 85175-59-3
- Chemical Name
- (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one
- Synonyms
- 7,8-Dimethoxy-3-(3-chloropropyl)-1,3-dihydro-2H-3-benzazepin-2-one;3-(3-chloropropyl)-7,8-diMethoxy-1H-benzo[d]azepin-2(3H)-one;3-(3-Chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one;-2-one;Ivabradin-1;Ivabradine Impurity c;Ivabradine Impurity f;Ivabradine Impurity 64;Ivabradine intermediate2;(Z)-3-(3-chloropropyl)-7
- CBNumber
- CB01509856
- Molecular Formula
- C15H18ClNO3
- Formula Weight
- 295.76
- MOL File
- 85175-59-3.mol
More
Less
(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one Property
- Melting point:
- 100-102 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 484.1±45.0 °C(Predicted)
- Density
- 1.191±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- -1.23±0.20(Predicted)
- color
- White to Off-White
More
Less
Safety
- HS Code
- 29339900
More
Less
N-Bromosuccinimide Price
TRC
- Product number
- C377615
- Product name
- 3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one
- Packaging
- 250mg
- Price
- $80
- Updated
- 2021/12/16
TRC
- Product number
- C377615
- Product name
- 3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one
- Packaging
- 5g
- Price
- $645
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FC151724
- Product name
- 3-(3-Chloro-propyl)-7,8-dimethoxy-1,3-dihydro-benzo[d]azepin-2-one
- Packaging
- 50mg
- Price
- $704
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0037471
- Product name
- 3-(3-CHLORO-PROPYL)-7,8-DIMETHOXY-1,3-DIHYDRO-BENZO[D]AZEPIN-2-ONE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $909.56
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FC151724
- Product name
- 3-(3-Chloro-propyl)-7,8-dimethoxy-1,3-dihydro-benzo[d]azepin-2-one
- Packaging
- 2mg
- Price
- $59
- Updated
- 2021/12/16
More
Less
(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one Chemical Properties,Usage,Production
synthetic
1.5g (6.8mmol) of 7,8-dimethoxy-1,3-dihydro-2h-3-benzoaza-2-one, 1.5g (9.5mmol) of 1,3-bromochloropropane and 6ml of DMF into a flask, raise the temperature of the mixture to 40 ℃, and add 0.8g of 40% sodium hydroxide (8mmol) solution. The mixture was then heated to 60 ° C and stirred for 2 hours; Add 30 ml of ice water and stir for 1 hour under the cooling of ice water bath. Filter out solid precipitates, wash and dry. The yield of the title compound was 85%.
Description
(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one is the side chain of ivabradine hydrochloride. Ivabradine and its medicinal salts, especially its hydrochloride, have very important pharmacological and therapeutic properties, especially, in slowing down the heart rate. Relating compounds can be used to treat or prevent various clinical myocardial ischemia conditions, such as angina pectoris, myocardial infarction and related rhythm disorders, various pathologies involving rhythm disorders, especially supraventricular rhythm disorders.
Uses
3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one is a reactant used in the synthesis of Zatebradine analogues as potential blockers od hyperpolarization-activated current.
Uses
(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one is an organic compound which can be used as pharmaceutical intermediates.
(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one Suppliers
More
Less
View Lastest Price from (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one manufacturers
Hebei Yanxi Chemical Co., Ltd.
- Product
- (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one 85175-59-3
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2023-10-23
Weijer International Trade (Hebei) Co., Ltd.
- Product
- (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H) 85175-59-3
- Price
- US $39.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5 Tons Per Day
- Release date
- 2021-09-27
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 7,8-dimethoxy-3- (3-chloropropyl) - 1,3-dihydro-2h-3-benzoazepine-2-one 85175-59-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
85175-59-3, (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-oneRelated Search:
3-[3-[[[(7S)-3,4-DiMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]Methyl]MethylaMino]propyl]-1,3-dihydro-7,8-diMethoxy-H-3-benzazepin-2-one
7-DeMethyl Ivabradine
7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one
N-DeMethyl Ivabradine Hydrochloride
3,3'-(propane-1,3-diyl)bis(7,8-dimethoxy-1,3-dihydro-2H-benzo[d]azepin-2-one)
C-(3,4-DIMETHOXY-BICYCLO[4.2.0]OCTA-1(6),2,4-TRIEN-7-YL)-METHYLAMINE
(3,4-Dimethoxyphenyl)acetic acid
Hydroxy Ivabradine
N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide
8-DeMethyl Ivabradine
3-(3-Chloropropyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one
3,3'-(propane-1,3-diyl)bis(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one)
(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
4,5-Dimethoxy-1-cyanobenzocyclobutane
Ivabradine Impurity 70
1204612-29-2
3,4-dimethoxy-N-methylbenzamide