Aminoguanidine hydrochloride
- Product Name
- Aminoguanidine hydrochloride
- CAS No.
- 1937-19-5
- Chemical Name
- Aminoguanidine hydrochloride
- Synonyms
- 2-aminoguanidine hydrochloride;Aminoguanidine HCL;GUANYLHYDRAZINEHCL;AMINOGUANIDINE SALT;Aminoguanidine salts;CP-12009-18 tartrate;amino-guanidinhydrochloride;Aminoguanidine hydrochoride;Aminoguanadine hydrochloride;AMINOGUANIDINE HYDROCHLORIDE
- CBNumber
- CB7497900
- Molecular Formula
- CH7ClN4
- Formula Weight
- 110.54608
- MOL File
- 1937-19-5.mol
Aminoguanidine hydrochloride Property
- Melting point:
- 162-166 °C(lit.)
- vapor pressure
- 0Pa at 25℃
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Completely soluble in water
- form
- Crystals
- color
- White to off-white
- Water Solubility
- 506.7g/L at 20℃
- Merck
- 13,440
- BRN
- 3909606
- InChI
- InChI=1S/CH6N4.ClH/c2-1(3)5-4;/h4H2,(H4,2,3,5);1H
- InChIKey
- UBDZFAGVPPMTIT-UHFFFAOYSA-N
- SMILES
- N(N)C(=N)N.[H]Cl
- LogP
- -3.55 at 20℃
- CAS DataBase Reference
- 1937-19-5(CAS DataBase Reference)
- EPA Substance Registry System
- Hydrazinecarboximidamide, monohydrochloride (1937-19-5)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 396494
- Product name
- Aminoguanidine hydrochloride
- Purity
- ≥98%
- Packaging
- 25g
- Price
- $72.5
- Updated
- 2025/07/31
- Product number
- 396494
- Product name
- Aminoguanidine hydrochloride
- Purity
- ≥98%
- Packaging
- 100g
- Price
- $221
- Updated
- 2025/07/31
- Product number
- A1129
- Product name
- Aminoguanidine Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $55
- Updated
- 2025/07/31
- Product number
- A1129
- Product name
- Aminoguanidine Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 100g
- Price
- $119
- Updated
- 2025/07/31
- Product number
- 81530
- Product name
- Aminoguanidine (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10g
- Price
- $25
- Updated
- 2024/03/01
Aminoguanidine hydrochloride Chemical Properties,Usage,Production
Description
Aminoguanidine is equipotent to L-
Chemical Properties
white to off-white crystals
Uses
antitussive
Uses
Aminoguanidine hydrochloride may be employed as nitric oxide synthase (NOS) inhibitor to investigate its effect on the reduction of alveolar bone loss in ligature induced periodontitis in rats. It may be used in the synthesis of 5-guanylhydrazone derivatives, having antibacterial activity against antibacterial activity against both Escherichia coli and Staphylococcus aureus.
Uses
a-Glucosidase inhibitor; hydroxyethyl derivative of 1-deoxynojirimycin
Biological Functions
It is reported that aminoguanidine hydrochloride has two important biological effects. Firstly, it is effective for the prevention of formation of advanced glycation endproducts (AGEs) associated with pathogenesis of secondary complications to diabetes and with cardiovascular changes in aging. Aminoguanidine hydrochloride reacts rapidly with in vivo glycation α,β-dicarbonyl products such as methylglyoxal, glyoxal, and 3-deoxyglucosone to prevent the formation of AGEs.
Secondly, it inhibits of the individual isoforms of nitric oxide synthase (iNOS) which is one of three key enzymes generating nitric oxide (NO) from L-arginine. iNOS-derived nitric oxide plays an important role in numerous physiological (e.g. blood pressure regulation) and pathophysiological (e.g. inflammation) conditions.
General Description
Aminoguanidine hydrochloride has been reported in a study as inhibitor of animal nitric oxide (NO)-synthase. Crystal structure of aminoguanidine hydrochloride has been investigated by Fourier and least squares method. Its crystals were monoclinic and the guanidine part of the aminoguanidinium ion is planar.
Flammability and Explosibility
Not classified
Biochem/physiol Actions
Inhibits both constitutive and inducible nitric oxide synthetase.
References
[1] JOLY G.A. Effects of NG-Methyl-L-arginine, NG-Nitro-L-arginine, and Aminoguanidine on Constitutive and Inducible Nitric Oxide Synthase in Rat Aorta[J]. Biochemical and biophysical research communications, 1994, 199 1: Pages 147-154. DOI: 10.1006/bbrc.1994.1207
[2] J A CORBETT M L M. Selective inhibition of inducible nitric oxide synthase by aminoguanidine.[J]. Methods in enzymology, 1996, 268: 398-408. DOI: 10.1016/s0076-6879(96)68042-2
[3] H. RUETTEN C. T. Prevention of the Expression of Inducible Nitric Oxide Synthase by Aminoguanidine or Aminoethyl-Isothiourea in Macrophages and in the Rat[J]. Biochemical and biophysical research communications, 1996, 225 2: Pages 525-530. DOI: 10.1006/bbrc.1996.1206
Aminoguanidine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Aminoguanidine hydrochloride manufacturers
- Product
- AMINOGUANIDINE HYDROCHLORIDE 1937-19-5
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-05
- Product
- Aminoguanidine Hydrochloride 1937-19-5
- Price
- US $85.00-25.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-05-22
- Product
- aminoguanidine hydrochloride 1937-19-5
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.9%
- Supply Ability
- 200tons
- Release date
- 2024-04-08