ChemicalBook > CAS DataBase List > Aminoguanidine hydrochloride

Aminoguanidine hydrochloride

Product Name: Aminoguanidine hydrochloride
CAS No.: 1937-19-5
Chemical Name: Aminoguanidine hydrochloride
Synonyms: 2-aminoguanidine hydrochloride;Aminoguanidine HCL;GUANYLHYDRAZINEHCL;AMINOGUANIDINE SALT;Aminoguanidine salts;CP-12009-18 tartrate;amino-guanidinhydrochloride;Aminoguanidine hydrochoride;Aminoguanadine hydrochloride;AMINOGUANIDINE HYDROCHLORIDE
CBNumber: CB7497900
Molecular Formula: CH7ClN4
Formula Weight: 110.54608
MOL File: 1937-19-5.mol

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Aminoguanidine hydrochloride Property

Melting point:: 162-166 °C(lit.)
vapor pressure: 0Pa at 25℃
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Completely soluble in water
form: Crystals
color: White to off-white
Water Solubility: 506.7g/L at 20℃
Merck: 13,440
BRN: 3909606
InChI: InChI=1S/CH6N4.ClH/c2-1(3)5-4;/h4H2,(H4,2,3,5);1H
InChIKey: UBDZFAGVPPMTIT-UHFFFAOYSA-N
SMILES: N(N)C(=N)N.[H]Cl
LogP: -3.55 at 20℃
CAS DataBase Reference: 1937-19-5(CAS DataBase Reference)
EPA Substance Registry System: Hydrazinecarboximidamide, monohydrochloride (1937-19-5)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: ME8430000
F: 10-21
HS Code: 29280000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 396494
Product name: Aminoguanidine hydrochloride
Purity: ≥98%
Packaging: 25g
Price: $72.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: 396494
Product name: Aminoguanidine hydrochloride
Purity: ≥98%
Packaging: 100g
Price: $221
Updated: 2025/07/31

TCI Chemical

Product number: A1129
Product name: Aminoguanidine Hydrochloride
Purity: >98.0%(T)
Packaging: 25g
Price: $55
Updated: 2025/07/31

TCI Chemical

Product number: A1129
Product name: Aminoguanidine Hydrochloride
Purity: >98.0%(T)
Packaging: 100g
Price: $119
Updated: 2025/07/31

Cayman Chemical

Product number: 81530
Product name: Aminoguanidine (hydrochloride)
Purity: ≥98%
Packaging: 10g
Price: $25
Updated: 2024/03/01

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Aminoguanidine hydrochloride Chemical Properties,Usage,Production

Description

Aminoguanidine is equipotent to L-NMMA and L-NNA as an inhibitor of iNOS. The IC₅₀ values for inhibition of mouse iNOS and rat nNOS are 5.4 and 160 μM, respectively. Aminoguanidine also inhibits induction of iNOS protein expression by endotoxin in rat macrophages. Aminoguanidine Hydrochloride is used in the synthetic preparation of highly selective and potent G-protein-coupled receptor kinase 2 (GRK2) inhibitor for potential treatment of heart failure.

Chemical Properties

white to off-white crystals

Uses

antitussive

Uses

Aminoguanidine hydrochloride may be employed as nitric oxide synthase (NOS) inhibitor to investigate its effect on the reduction of alveolar bone loss in ligature induced periodontitis in rats. It may be used in the synthesis of 5-guanylhydrazone derivatives, having antibacterial activity against antibacterial activity against both Escherichia coli and Staphylococcus aureus.

Uses

a-Glucosidase inhibitor; hydroxyethyl derivative of 1-deoxynojirimycin

Biological Functions

It is reported that aminoguanidine hydrochloride has two important biological effects. Firstly, it is effective for the prevention of formation of advanced glycation endproducts (AGEs) associated with pathogenesis of secondary complications to diabetes and with cardiovascular changes in aging. Aminoguanidine hydrochloride reacts rapidly with in vivo glycation α,β-dicarbonyl products such as methylglyoxal, glyoxal, and 3-deoxyglucosone to prevent the formation of AGEs.
Secondly, it inhibits of the individual isoforms of nitric oxide synthase (iNOS) which is one of three key enzymes generating nitric oxide (NO) from L-arginine. iNOS-derived nitric oxide plays an important role in numerous physiological (e.g. blood pressure regulation) and pathophysiological (e.g. inflammation) conditions.

General Description

Aminoguanidine hydrochloride has been reported in a study as inhibitor of animal nitric oxide (NO)-synthase. Crystal structure of aminoguanidine hydrochloride has been investigated by Fourier and least squares method. Its crystals were monoclinic and the guanidine part of the aminoguanidinium ion is planar.

Flammability and Explosibility

Not classified

Biochem/physiol Actions

Inhibits both constitutive and inducible nitric oxide synthetase.

References

[1] JOLY G.A. Effects of NG-Methyl-L-arginine, NG-Nitro-L-arginine, and Aminoguanidine on Constitutive and Inducible Nitric Oxide Synthase in Rat Aorta[J]. Biochemical and biophysical research communications, 1994, 199 1: Pages 147-154. DOI: 10.1006/bbrc.1994.1207
[2] J A CORBETT M L M. Selective inhibition of inducible nitric oxide synthase by aminoguanidine.[J]. Methods in enzymology, 1996, 268: 398-408. DOI: 10.1016/s0076-6879(96)68042-2
[3] H. RUETTEN C. T. Prevention of the Expression of Inducible Nitric Oxide Synthase by Aminoguanidine or Aminoethyl-Isothiourea in Macrophages and in the Rat[J]. Biochemical and biophysical research communications, 1996, 225 2: Pages 525-530. DOI: 10.1006/bbrc.1996.1206

Aminoguanidine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Aminoguanidine hydrochloride manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: AMINOGUANIDINE HYDROCHLORIDE 1937-19-5
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-05

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Aminoguanidine Hydrochloride 1937-19-5
Price: US $85.00-25.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-22

airuikechemical co., ltd.

Product: aminoguanidine hydrochloride 1937-19-5
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 200tons
Release date: 2024-04-08

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NH2NHCNHNH2HCl

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Signalling

TUSACAPINE

Nitric Oxide

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