ChemicalBook > CAS DataBase List > (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride
(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride
Uses- Product Name
- (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride
- CAS No.
- 866783-13-3
- Chemical Name
- (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride
- Synonyms
- Ivabradine Impurity 17 HCl;(1R)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride;(7S)-3,4-Dimethoxy-N-methylbicyclo[4.2.0]octa-1,3,5-triene-7-methanamine hydrochloride;(1S)-4;Ivabradine RC 6 (HCl);Ivebradine impurity 3;Ivabradine Impurity 85;Ivabradine Intermediate;Ivabradine intermediate1;Ivabradine Impurity 7 HCL
- CBNumber
- CB01455900
- Molecular Formula
- C12H18ClNO2
- Formula Weight
- 243.73
- MOL File
- 866783-13-3.mol
More
Less
(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride Property
- Melting point:
- >216°C (dec.)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1/C12H17NO2.ClH/c1-13-7-9-4-8-5-11(14-2)12(15-3)6-10(8)9;/h5-6,9,13H,4,7H2,1-3H3;1H/t9-;/s3
- InChIKey
- SWSAIQSQSDOONK-OVMXBOEKNA-N
- SMILES
- COC1=CC2[C@@H](CNC)CC=2C=C1OC.Cl |&1:5,r|
- CAS DataBase Reference
- 866783-13-3(CAS DataBase Reference)
More
Less
Safety
- HS Code
- 29214990
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
More
Less
N-Bromosuccinimide Price
TRC
- Product number
- D461760
- Product name
- (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutaneHydrochloride
- Packaging
- 250mg
- Price
- $110
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FD150184
- Product name
- (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutaneHydrochloride
- Packaging
- 500mg
- Price
- $125
- Updated
- 2021/12/16
AK Scientific
- Product number
- X0048
- Product name
- (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutanehydrochloride
- Packaging
- 250mg
- Price
- $130
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FD150184
- Product name
- (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutaneHydrochloride
- Packaging
- 1g
- Price
- $200
- Updated
- 2021/12/16
AK Scientific
- Product number
- X0048
- Product name
- (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutanehydrochloride
- Packaging
- 1g
- Price
- $250
- Updated
- 2021/12/16
More
Less
(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride Chemical Properties,Usage,Production
Uses
(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride is an intermediate used in preparation of Ivabradine (I940500) which is a selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node.
Uses
(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane is an intermediate used in preparation of Ivabradine (I940500) which is a selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node.
Synthesis
866783-12-2
866783-13-3
The general procedure for the synthesis of (1S)-4,5-dimethoxy-1-methylaminomethyl-benzocyclobutane hydrochloride from (S)-1-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)-N-methylmethylamine is as follows: (1S)-4,5-dimethoxy-1-methylaminomethyl-benzocyclobutane hydrochloride, which was obtained from the previous step, was was dissolved in a solvent mixture of ethyl acetate (20 mL) and ethanol (5 mL) and stirred at 20 °C. Subsequently, hydrogen chloride gas was passed into the reaction solution and stirring was continued at 15 °C - 20 °C for 1 hour until the reaction solution became turbid. After completion of the reaction, the reaction mixture was washed with a mixed solvent of ethyl acetate/ethanol (4:1, v/v) and dried to afford (1S)-4,5-dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride (2.38 g, 95% yield).
References
[1] Patent: CN104557573, 2018, B. Location in patent: Paragraph 0109; 0116; 0121; 0122
[2] Patent: US2005/261376, 2005, A1. Location in patent: Page/Page column 3
(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride Suppliers
- Tel
- 0571-88938669 18667135863
- wps@highfine.com
- Country
- China
- ProdList
- 165
- Advantage
- 60
- Tel
- 0531-68654990 18560195202
- Fax
- 053168654990
- leadgxm@leadchem.net
- Country
- China
- ProdList
- 174
- Advantage
- 58
- Tel
- 0531-82375892 15553111391
- 3276840968@qq.com
- Country
- China
- ProdList
- 301
- Advantage
- 58
- Tel
- 13303867194
- 3001317055@qq.com
- Country
- China
- ProdList
- 9681
- Advantage
- 58
- Tel
- 0518-8021621 15062910926
- sales@jsytsw.com
- Country
- China
- ProdList
- 80
- Advantage
- 58
- Tel
- 010-83386758 18810831598
- Fax
- 010-83386758
- sales@lianben.com
- Country
- China
- ProdList
- 94
- Advantage
- 58
- Tel
- 0575-13967584673 13967584673
- jianqiu21@sina.com
- Country
- China
- ProdList
- 39
- Advantage
- 58
- Tel
- +86-21-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6003
- Advantage
- 61
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9310
- Advantage
- 66
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 15527768836
- 1791901229@qq.com
- Country
- China
- ProdList
- 6950
- Advantage
- 52
- Tel
- 021-50460086-9 15921403865
- Fax
- +86-21-50462321
- han_yajun@dctc.daicel.com
- Country
- China
- ProdList
- 7471
- Advantage
- 65
- Tel
- 18270980682
- Fax
- 021 51613951
- mlcheng@sunwaypharm.cn
- Country
- China
- ProdList
- 8669
- Advantage
- 57
- Tel
- 0512-63263366 18912765016
- Fax
- 0512-6326 3366
- tongtf110@sina.com
- Country
- China
- ProdList
- 993
- Advantage
- 62
- Tel
- 0871-65217109 13211707573;
- Fax
- 0871-65215563
- y.liu@mail.biobiopha.com
- Country
- China
- ProdList
- 5645
- Advantage
- 65
- Tel
- 021-61551611 13296011611
- Fax
- ＋86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9895
- Advantage
- 58
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9891
- Advantage
- 58
- Tel
- +86(0)21 60484900
- Fax
- +86(0)21 60484900
- Country
- China
- ProdList
- 764
- Advantage
- 50
- Tel
- 020-39119399 18927568969
- Fax
- 020-39119999
- isunpharm@qq.com
- Country
- China
- ProdList
- 4720
- Advantage
- 55
- Tel
- +86-10-83386766
- Fax
- +86-10-83386758
- sales@lianben.com
- Country
- China
- ProdList
- 91
- Advantage
- 58
- Tel
- 021-61119791,13386096464
- Fax
- 021-50190009
- bzswkf@foxmail.com
- Country
- China
- ProdList
- 3921
- Advantage
- 50
- Tel
- 13971561712, 13995564702, 027-50664929
- Fax
- 027-50664927
- hbeixys2001@163.com
- Country
- China
- ProdList
- 3120
- Advantage
- 55
- Tel
- 021-60549325 18616193163
- Fax
- 021-33250306
- Country
- China
- ProdList
- 4526
- Advantage
- 56
- Tel
- 0523-86818997 18652728585
- sales@allyrise.com
- Country
- China
- ProdList
- 2966
- Advantage
- 60
- Tel
- 086-0531-86986713
- Fax
- 086-0531-86980810
- aplgroup@163.com
- Country
- China
- ProdList
- 96
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- +86-021-50890968，021-50891159 +86-18601776121
- Fax
- 086-21-68416099 58604179
- danny@urchem.com
- Country
- China
- ProdList
- 628
- Advantage
- 58
- Tel
- 0510-85629785 18013409632
- Fax
- 051085625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 15178
- Advantage
- 58
- Tel
- 027-87465837 19945049750
- Fax
- 027-8777-2287
- sales@finetechnology-ind.com
- Country
- China
- ProdList
- 9637
- Advantage
- 58
- Tel
- 86-574-27787657
- Fax
- 86-574-27912196
- info@dearchem.com
- Country
- China
- ProdList
- 4613
- Advantage
- 58
- Tel
- 027-59262863 13277907145 3091977954
- Fax
- 027-59420980
- Country
- China
- ProdList
- 4942
- Advantage
- 58
- Tel
- 021-60345187 13671753212
- Fax
- 021-34702061
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 10263
- Advantage
- 55
- Tel
- 021-64609169 18901607656
- Fax
- 021-64609160
- greensnown@163.com
- Country
- China
- ProdList
- 9906
- Advantage
- 50
- Tel
- 0571-87396432
- Fax
- 0571-87396431
- sales@jhechem.com
- Country
- China
- ProdList
- 14912
- Advantage
- 59
- Tel
- 027-88395709
- Fax
- 027-88391805
- Country
- China
- ProdList
- 429
- Advantage
- 50
- Tel
- 025-57018978 18251899859
- Fax
- 025-57018008
- sales@chalf-pharm.com
- Country
- China
- ProdList
- 5674
- Advantage
- 50
- Tel
- 0571-86403260 86403970
- Fax
- 0571-86403970
- lucky@lkbiology.com
- Country
- China
- ProdList
- 243
- Advantage
- 58
- Tel
- +86-0579-86846643 18072368515
- Fax
- +86-0579-86846643
- sales@honsentech.com.cn
- Country
- China
- ProdList
- 124
- Advantage
- 55
- Tel
- 010-88755821 13911359480
- sophia_818@126.com
- Country
- China
- ProdList
- 294
- Advantage
- 55
- Tel
- 86(21)68097365
- Fax
- 86(21)33321566
- sales@anpharma.net
- Country
- China
- ProdList
- 4891
- Advantage
- 55
- Tel
- 025-58362220 0086-15250997978
- Fax
- 025-58362220
- sale@njxizebio.com
- Country
- China
- ProdList
- 4855
- Advantage
- 55
- Tel
- 13585175604 13057662806
- Fax
- +86-25-52261140
- sales@chicopharm.com
- Country
- China
- ProdList
- 500
- Advantage
- 65
- Tel
- 0512-63009836 18994340901
- Fax
- 0512-63006936
- helen@struchem.com
- Country
- China
- ProdList
- 3981
- Advantage
- 60
- Tel
- 027-51335350 15107175693
- Fax
- 027-51335350
- bosenyuan@foxmail.com
- Country
- China
- ProdList
- 192
- Advantage
- 55
- Tel
- 021-50908862，442785678，326799392 18721037013
- Fax
- 021-50908862
- siyansales@126.com
- Country
- China
- ProdList
- 9627
- Advantage
- 58
- Tel
- 526763801 13301653310
- Fax
- +86-21-51619052
- 526763801@qq.com
- Country
- China
- ProdList
- 9279
- Advantage
- 55
- Tel
- 0371-53778726 18003825608
- Fax
- QQ：2885354392
- liuxiaoyan@alfachem.cn
- Country
- China
- ProdList
- 1986
- Advantage
- 58
More
Less
View Lastest Price from (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride manufacturers
Hebei Yanxi Chemical Co., Ltd.
- Product
- (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride 866783-13-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 500kg/M
- Release date
- 2023-09-06
Hangzhou ICH Biofarm Co., Ltd
- Product
- (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride 866783-13-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.1kg
- Purity
- 99.0%min
- Supply Ability
- 200kg
- Release date
- 2023-06-09
Weijer International Trade (Hebei) Co., Ltd.
- Product
- (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride 866783-13-3
- Price
- US $13.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2021-10-08
866783-13-3, (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochlorideRelated Search:
Idarubicin hydrochloride
Dimethylamine hydrochloride
4-AMINOAZOBENZENE HYDROCHLORIDE
4-Dimethylaminobenzaldehyde
Basic Violet 1
Methyl acrylate
Tribenuron methyl
Methyl salicylate
Methanol
D-Glucosamine hydrochloride
Kresoxim-methyl
Topotecan hydrochloride
Methylparaben
(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one
Voriconazole
Dimethoxymethane
Aminoguanidine hydrochloride
Irinotecan hydrochloride