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(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine

Product Name
(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine
CAS No.
1156491-10-9
Chemical Name
(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine
Synonyms
(1S,2R)-2-(3,4-difluorophenyl)cyclopropanaMine;(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride;(1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine Hydrochloride(1:1);(1R trans)-2-(3,4-difluorophenyl)cyclopropane aMine hydrochloride;Ticagrelor USP RC A;Ticagrelor side chain 2 hydrochloride;2-(3,4-Difluoro-phenyl)-cyclopropylamine;(1R,2S)-rel-2-(3,4- Difluorophenyl)cyclo;(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanami;(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine HCl
CBNumber
CB22498775
Molecular Formula
C9H10ClF2N
Formula Weight
205.63
MOL File
1156491-10-9.mol
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(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine Property

Melting point:
>172°C (dec.)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-M1888
Product name
(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanaminehydrochloride
Purity
≥99.0%
Packaging
25g
Price
$188
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
93228
Product name
(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamineHydrochloride
Packaging
250mg
Price
$370
Updated
2021/12/16
AK Scientific
Product number
J96448
Product name
(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanaminehydrochloride
Packaging
25g
Price
$500
Updated
2021/12/16
Ambeed
Product number
A143878
Product name
(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanaminehydrochloride
Purity
98%
Packaging
250mg
Price
$7
Updated
2021/12/16
Ambeed
Product number
A143878
Product name
(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanaminehydrochloride
Purity
98%
Packaging
1g
Price
$11
Updated
2021/12/16
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(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine Chemical Properties,Usage,Production

Uses

(1S,2R)-2-(3,4-Difluorophenyl)-cyclopropanamine is an intermediate used to prepare ticagrelor (T437700).

Synthesis Reference(s)

Synthesis of 2-(3,4-difluorophenyl)cyclopropanamine derivatives and salts. EU Patent EP2644590A1

Synthesis

1,2-Difluorobenzene is reacted with 3-chloropropionyl chloride to produce 3-chloro-1-(3',4'-difluorophenyl)-propan-1-one, which is by addition of N,N-dimethylformamide, phloroglucinol and sodium iodide in the next step converted to 1-(3',4'-difluorophenyl)-3-nitro-propan-1-one. The keto group of the latter intermediate is in the subsequent step stereochemically reduced to hydroxyl group by the use of chiral oxazaborolidine together with borane dimethyl sulfide or borane-N,N-diethyl aniline complex in the presence of tetrahydrofurane. The obtained (1R)-1-(3',4'-difluorophenyl)-3-nitro-propan-1-ol is then added to a mixture of triphenylphosphine and diethylazodicarboxylate in benzene to yield (1S,2R)-2-(3',4'-difluorophenyl)-1-nitrocyclopropane, which is in the last step converted to 2-(3,4-difluorophenyl)cyclopropane amine by reduction of the nitro group by catalytic hydrogenation with palladium catalyst and zink dust. 

(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine Preparation Products And Raw materials

Raw materials

Preparation Products

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(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine Suppliers

Jiangsu Vcare PharmaTech Co., Ltd.
Tel
025-58741518; 18013018875
Fax
+86-25-58744115
Email
sales@vcarepharmatech.com
Country
China
ProdList
308
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61
Shanghai Shanyuan pharmaceutical technology co., LTD
Tel
021-31761238 13167072949
Fax
021-31761238
Email
3146446224@qq.com
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China
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iangsu U-Liy Biotech Pharmaceuticals Inc
Tel
18021412923
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1515809609@qq.com
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China
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Jiaxing Xinbelai Biotechnology Co., LTD
Tel
18667946270 18167156872
Email
guopeng@synbiolab.cn
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China
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ZhengZhou Edward Biology Co.,Ltd
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13298105281
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893596907@qq.com
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China
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956
Fax
0573-85285100
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isenchem@163.com
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China
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9555
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Adamas Reagent, Ltd.
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400-6009262 16621234537
Fax
021-64823266
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zhangsn@titansci.com
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China
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Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
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China
ProdList
4531
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Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
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4388
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Anhui nuoquan pharmaceutical co. LTD
Tel
0556-5032870 15705561919
Fax
0556-5032869
Email
sujuan.mei@nuoquanpharm.com
Country
China
ProdList
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View Lastest Price from (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride 1156491-10-9
Price
US $30.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2000kg
Release date
2024-03-22
Hebei Yanxi Chemical Co., Ltd.
Product
(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine 1156491-10-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99
Supply Ability
20tons
Release date
2023-10-24
Zhuhai Hairuide Bioscience and Technology Co., Ltd
Product
(1R,2S)-2-(3,4-difluorophenyl)cyclopropane amine Hydrochloride 1156491-10-9
Price
US $0.00/KG Ton
Min. Order
1KG Ton
Purity
98%+
Supply Ability
2 tons/month
Release date
2022-10-09

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