ChemicalBook > CAS DataBase List > (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride

(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride

Product Name: (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride
CAS No.: 1156491-10-9
Chemical Name: (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride
Synonyms: (1S,2R)-2-(3,4-difluorophenyl)cyclopropanaMine;(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride;(1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine Hydrochloride(1:1);(1R trans)-2-(3,4-difluorophenyl)cyclopropane aMine hydrochloride;Ticagrelor USP RC A;Ticagrelor side chain 2 hydrochloride;Ticagrelor Impurity 305 Hydrochloride;2-(3,4-Difluoro-phenyl)-cyclopropylamine;(1R,2S)-rel-2-(3,4- Difluorophenyl)cyclo;(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanami
CBNumber: CB22498775
Molecular Formula: C9H10ClF2N
Formula Weight: 205.63
MOL File: 1156491-10-9.mol

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(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride Property

Melting point:: >172°C (dec.)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: White
InChI: InChI=1/C9H9F2N.ClH/c10-7-2-1-5(3-8(7)11)6-4-9(6)12;/h1-3,6,9H,4,12H2;1H/t6-,9+;/s3
InChIKey: IMYLOCHFFLYHPS-RHUSADAZNA-N
SMILES: N[C@@H]1C[C@H]1C1C=CC(F)=C(F)C=1.Cl |&1:1,3,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-M1888
Product name: (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanaminehydrochloride
Purity: ≥99.0%
Packaging: 25g
Price: $188
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 93228
Product name: (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamineHydrochloride
Packaging: 250mg
Price: $370
Updated: 2021/12/16

AK Scientific

Product number: J96448
Product name: (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanaminehydrochloride
Packaging: 25g
Price: $500
Updated: 2021/12/16

Alichem

Product number: 1156491109
Product name: (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanaminehydrochloride
Packaging: 25g
Price: $505
Updated: 2021/12/16

Chemenu

Product number: CM117627
Product name: trans-2-(3,4-Difluorophenyl)cyclopropanamineHydrochloride
Purity: 95+%
Packaging: 1000g
Price: $960
Updated: 2021/12/16

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(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride Chemical Properties,Usage,Production

Uses

(1S,2R)-2-(3,4-Difluorophenyl)-cyclopropanamine is an intermediate used to prepare ticagrelor (T437700).

Synthesis Reference(s)

Synthesis of 2-(3,4-difluorophenyl)cyclopropanamine derivatives and salts. EU Patent EP2644590A1

Synthesis

1,2-Difluorobenzene is reacted with 3-chloropropionyl chloride to produce 3-chloro-1-(3',4'-difluorophenyl)-propan-1-one, which is by addition of N,N-dimethylformamide, phloroglucinol and sodium iodide in the next step converted to 1-(3',4'-difluorophenyl)-3-nitro-propan-1-one. The keto group of the latter intermediate is in the subsequent step stereochemically reduced to hydroxyl group by the use of chiral oxazaborolidine together with borane dimethyl sulfide or borane-N,N-diethyl aniline complex in the presence of tetrahydrofurane. The obtained (1R)-1-(3',4'-difluorophenyl)-3-nitro-propan-1-ol is then added to a mixture of triphenylphosphine and diethylazodicarboxylate in benzene to yield (1S,2R)-2-(3',4'-difluorophenyl)-1-nitrocyclopropane, which is in the last step converted to 2-(3,4-difluorophenyl)cyclopropane amine by reduction of the nitro group by catalytic hydrogenation with palladium catalyst and zink dust.

(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride manufacturers

HEBEI BRANT PHARMACEUTICAL CO.,LTD

Product: (1R,trans)-2-(3,4-difluorophenyl) Cyclopropanamine hydrochloride 1156491-10-9
Price: US $0.00-0.00/kg
Min. Order: 2kg
Purity: 99.9%
Supply Ability: 20 tons
Release date: 2025-07-04

Qingdao RENAS Polymer Material Co., Ltd.

Product: (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine hydrochloride 1156491-10-9
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-10-29

S&Y Biochem Co.,Ltd

Product: (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine 1156491-10-9
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98
Supply Ability: 1000
Release date: 2024-08-01

1156491-10-9, (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochlorideRelated Search:

Canagliflozin Tetrahydro-2,2-dimethyl-4,7-methano-6H-1,3-dioxolo[4,5-d][1,2]oxazine-6-carboxylic acid phenylmethyl ester 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride 1-[2-Amino-1-(4-methoxyphenyl)-ethyl]-cyclohexanol hydrochloride 4-(4-Methylpiperazinylmethyl)benzoyl chloride dihydrochloride TICAGRELOR 2-((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)ethanol L-tataric acid 4,6-dichloro-2-propylthiopyrimidine-5-amine 4,6-DICHLORO-5-NITRO-2-PROPYLTHIOPYRIMIDINE (3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate 1-Acetyladamantane Intermediate (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine. HCl Ethanol, 2-[[(3aR,4S,6R,6aS)-6-[[5-aMino-6-chloro-2-(propylthio)-4-pyriMidinyl]aMino]tetrahydro-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]- ethyCyclopropanamine, 2-(3,4-difluorophenyl)-, (1R,2S)- (REACH) (1R,2R)-2-(3,4-difluorophenyl)cyclopropane carboxaMide CarbaMicacid,N-[(3aS,4R,6S,6aR)-tetrahydro-6-hydroxy-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-yl]-,phenylMethyl ester Cyclopropanamine,2-(3,4-difluorophenyl)-(1R,2S) -(2R,3R)-2,3-dihydroxybutanedioate (1:1)

(1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine Hydrochloride(1:1)

(1R,2S)-2-(3,4-Difluorophenyl)-cyclopropan-1-aMine HCL

(1R trans)-2-(3,4-difluorophenyl)cyclopropane aMine hydrochloride

(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanami

2-(3,4-Difluoro-phenyl)-cyclopropylamine

(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine

(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride

CYCLOPROPANAMINE, 2-(3,4-DIFLUOROPHENYL)-, HYDROCHLORIDE (1:1), (1R,2S)-REL-

(1S,2R)-2-(3,4-difluorophenyl)cyclopropanaMine

trans-(1R,2S)-2-(3,4-difluorphenyl)cyclopropylaMine

(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine HCl

(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine HCl

trans-(1R,2S)-2-(3,4-Diflurophenyl)cyclopropylamine hydrochloride

(1R,2S)-2-(3,4-difluorophenyl)cyclopropane amine hydrochloride

trans-2-(3,4-Difluorophenyl)cyclopropanamine Hydrochloride

Ticagrelor USP RC A

trans-rel-2-(3,4-Difluorophenyl)cyclopropanamine Hydrochloride

Ticagrelor side chain 2 hydrochloride

(1R,2S)-REL-2-(3,4-difluorophenyl)cyclopropane amine chloride

(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine hydrochl...

(1R,2S)-rel-2-(3,4-Difluorophenyl) cyclopropanamine hydrochlorideQ: What is (1R,2S)-rel-2-(3,4-Difluorophenyl) cyclopropanamine hydrochloride Q: What is the CAS Number of (1R,2S)-rel-2-(3,4-Difluorophenyl) cyclopropanamine hydrochloride Q: What is the storage condition of (1R,2S)-rel-2-(3,4-Difluorophenyl) cyclopropanamine hydrochloride

(1R,2S)-2-(3,4-Diflurophenyl)cyclopropylamine hydrochloride,

(1R,2S)-rel-2-(3,4-Difluorophenyl)-cyclopropanamine hydrochloride (1:1)

(1R, 2S) - REL-2- (3,4-difluorophenyl) cyclopropylamine hydrochloride

1R trans)-2-(3,4-difluorophenyl)cyclopropane amine in stock

(1R,2S)-rel-2-(3,4- Difluorophenyl)cyclo

(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochlo

trans)-2-(3,4-difluorophenyl)cyclopropane amine hydrochloride

(1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine hydrochloride

(1R,2S)-Rel-2-(3,4-Difluorophenyl)-Cyclopropanamine Hydr

(1R,trans)-2-(3,4-difluorophenyl) Cyclopropanamine hydrochloride

Ticagrelor Impurity 305 Hydrochloride

1156491-10-9

C9H9F2NHCl

Intermediate of Ticagrelor

1156491-10-9