ChemicalBook > CAS DataBase List > 4,6-dichloro-2-propylthiopyrimidine-5-amine

4,6-dichloro-2-propylthiopyrimidine-5-amine

Product Name
4,6-dichloro-2-propylthiopyrimidine-5-amine
CAS No.
145783-15-9
Chemical Name
4,6-dichloro-2-propylthiopyrimidine-5-amine
Synonyms
4,6-Dichloro-2-(propylthio)pyrimidin-5-amine;oro-2-propyL;Ticagrelor Impurity U;thiopyrimidine-5-amine;Ticagrelor Impurity 110;Tecagrelor InterMediate 3;Ticagrelor Intermediate ide;2-propylthiopyrimidine-5-amine;6-dichloro-2-propylthiopyrimidine-5-amine;4,6-Dichloro-2-(propylthio)pyriMidin-aMine
CBNumber
CB92487693
Molecular Formula
C7H9Cl2N3S
Formula Weight
238.14
MOL File
145783-15-9.mol
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4,6-dichloro-2-propylthiopyrimidine-5-amine Property

Boiling point:
334.1±37.0 °C(Predicted)
Density 
1.44
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to lump to clear liquid
pka
-3.46±0.12(Predicted)
color 
White or colorless to Brown
Water Solubility 
100mg/L at 22℃
InChI
InChI=1S/C7H9Cl2N3S/c1-2-3-13-7-11-5(8)4(10)6(9)12-7/h2-3,10H2,1H3
InChIKey
CJJLJBFJNXMANZ-UHFFFAOYSA-N
SMILES
C1(SCCC)=NC(Cl)=C(N)C(Cl)=N1
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Safety

Safety Statements 
24/25
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical
Product number
A2716
Product name
5-Amino-4,6-dichloro-2-(propylthio)pyrimidine
Purity
>98.0%(GC)
Packaging
1g
Price
$58
Updated
2024/03/01
TCI Chemical
Product number
A2716
Product name
5-Amino-4,6-dichloro-2-(propylthio)pyrimidine
Purity
>98.0%(GC)
Packaging
5g
Price
$175
Updated
2024/03/01
BroadPharm
Product number
BP-20662
Product name
4,6-dichloro-2-(propylthio)pyrimidin-5-amine
Packaging
100mg
Price
$180
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD16313
Product name
4,6-Dichloro-2-(propylthio)pyrimidin-5-amine
Packaging
500g
Price
$235
Updated
2021/12/16
SynQuest Laboratories
Product number
7H66-5-72
Product name
4,6-Dichloro-2-(propylsulfanyl)pyrimidin-5-amine
Purity
97.0%
Packaging
100g
Price
$260
Updated
2021/12/16
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4,6-dichloro-2-propylthiopyrimidine-5-amine Chemical Properties,Usage,Production

Description

4,6-dichloro-2-propylthiopyrimidine-5-amine is a pharmaceutical intermediate used in the preparation of Ticagrelor, which belongs to a class of drugs called antiplatelet agents. It works by preventing platelets (a type of blood cell) from aggregating and forming clots that can lead to heart attacks or strokes.

Chemical Properties

Light pink to dark brown liquid or semi solid

Uses

Intermediate in the preparation of Ticagrelor (T437700) and reversible P2Y12 receptor antagonists.

Synthesis

The synthesis of 4,6-dichloro-2-propylthiopyrimidine-5-amine is as follows：tert-Butyl methyl ether (370 g) was placed under nitrogen in a 1 L stainless steel autoclave equipped with a temperature-controlled jacket, an Ekato InterMIG stirrer, an internal temperature sensor and a dip pipe, and 4,6-dichloro-5-nitro-2-propylsulfanyl-pyrimidine (94.5 g, 0.35 mol) was added and dissolved at a stirring rate of 200 min-1. The catalyst suspension was prepared and transferred into the autoclave as described in the preceding example. The autoclave was sealed and the stirring rate was increased to 600 min-1 while the autoclave was purged four times with nitrogen. Subsequently, hydrogen gas feed via the dip pipe at a constant flow rate (pmax=10 bar) as well as a heating-up ramp (45 K/h) from 20° C. to 65° C. were started in parallel, while stirring at 600 min-1. The progress of the exothermic reaction was followed by recording the hydrogen uptake as well as the internal and jacket temperature curve. Upon completion of the hydrogen uptake (ca. 1.1 mol or 3 molar equivalents) after about 4 h, stirring of the reaction mixture was continued for an additional 3 hours at 65° C. After unloading the autoclave (the reactor was cooled down to 20° C., the hydrogen pressure was released and the reactor purged four times with nitrogen), the catalyst was filtered off. The autoclave as well as the filter cake (catalyst) were washed with tent-butyl methyl ether (185 g). The organic phases were combined and the water layer separated. An IPC-sample was taken to analyze the product mixture. The conversion was found to be quantitative with no nitroso or hydroxylamine intermediate being detectable.

4,6-dichloro-2-propylthiopyrimidine-5-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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4,6-dichloro-2-propylthiopyrimidine-5-amine Suppliers

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View Lastest Price from 4,6-dichloro-2-propylthiopyrimidine-5-amine manufacturers

S&Y Biochem Co.,Ltd
Product
4,6-dichloro-2-propylthiopyrimidine-5-amine 145783-15-9
Price
US $1.00/kg
Min. Order
1kg
Purity
99
Supply Ability
1000
Release date
2024-08-01
Hebei Zhuanglai Chemical Trading Co Ltd
Product
4,6-dichloro-2-propylthiopyrimidine-5-amine 145783-15-9
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-11-13
Hebei Zhuanglai Chemical Trading Co Ltd
Product
4,6-dichloro-2-propylthiopyrimidine-5-amine 145783-15-9
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-11-13

145783-15-9, 4,6-dichloro-2-propylthiopyrimidine-5-amineRelated Search:

N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine TICAGRELOR 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione Canagliflozin Ticagrelor Sulfone Tetrahydro-2,2-dimethyl-4,7-methano-6H-1,3-dioxolo[4,5-d][1,2]oxazine-6-carboxylic acid phenylmethyl ester 2-((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)ethanol L-tataric acid 4,6-DICHLORO-5-NITRO-2-PROPYLTHIOPYRIMIDINE (3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate 1-Acetyladamantane Intermediate (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine. HCl Ethanol, 2-[[(3aR,4S,6R,6aS)-6-[[5-aMino-6-chloro-2-(propylthio)-4-pyriMidinyl]aMino]tetrahydro-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]- ethyCyclopropanamine, 2-(3,4-difluorophenyl)-, (1R,2S)- (REACH) (1R,2R)-2-(3,4-difluorophenyl)cyclopropane carboxaMide (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine CarbaMicacid,N-[(3aS,4R,6S,6aR)-tetrahydro-6-hydroxy-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-yl]-,phenylMethyl ester

  • 4,6-dichloro-2-propylthiopyrimidine-5-amine
  • 4,6-dichloro-2-(propylthio)-5-PyriMidinaMine
  • 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine
  • Tecagrelor InterMediate 3
  • 5-PyriMidinaMine, 4,6-dichloro-2-(propylthio)-
  • 4,6-dichloro-2-(propylsulfanyl)-5-pyriMidinaMine
  • Ticagrelor Impurity 110
  • 4,6-Dichloro-5-amino-2-propylthiopyrimidine
  • 4,6-dichloro-2-(propylsulfanyl)pyriMidin-5-aMine
  • 4,6-Dichloro-2-propylsulfanyl-pyriMidin-5-ylaMine
  • 4,6-Dichloro-2-(propylthio)pyriMidin-aMine
  • 5-Amino-4,6-dichloro-2-(propylthio)pyrimidine
  • 4,6-DICHLORO-2-(PROPYLTHIO) PYRIMDIN-5-AMINE
  • Ticagrelor Impurity U
  • 5-Amino-4,6-dichloro-2-(propylthio)pyrimidine&gt
  • 2-propylthiopyrimidine-5-amine
  • oro-2-propyL
  • thiopyrimidine-5-amine
  • 4,6-dichloro-2-propylthiopyrimidine-5-amine ISO 9001：2015 REACH
  • 1-Acetyladamantane Intermediate，4,6-dichloro-2-propylthiopyrimidine-5- amine
  • 6-dichloro-2-propylthiopyrimidine-5-amine
  • 4, 6-dichloro-2-propyl thio-5-aminopyrimidine
  • Ticagrelor Intermediate ide
  • 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine? (Ticagrelor Impurity)
  • 4, 6-dichloro-2 -(propylthionyl) -5-aminopyrimidine
  • 4, 6-dichlor〇-2-propylthiopyrimidine-5- amine
  • 4,6-Dichloro-2-(Propylthio) pyrimidin-5-amine (TDP)
  • 4,6-Dichloro-2-(propylthio)-pyrimidin-5-ylamine
  • 4,6 dichloro-5amine - 2 - (propylthio) pyrimidine
  • Ticagrelor Intermediates4,6-Dichloro-2-propylsulfanyl-pyrimidin-5-ylamine
  • 5-Amino-4,6-dichloro-2- (propylthio)pyrimidin-
  • 4,6-dichloro-2-propylthio-pyrimidine-5-amin
  • 2-(((3aR,4S,6R,6aS)-6-(7-(isopropylamino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol
  • 145783-15-9
  • 1145783-15-9
  • C7H9Cl2N3S
  • Intermediate of Ticagrelor
  • bc0001
  • 145783-15-9