4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine

Product Name: 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine
CAS No.: 150728-13-5
Chemical Name: 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine
Synonyms: 4,6-Dich;Bosentan USP RC D;BOSENTAN INTERMEDIATES;Bosentan interMediate (I);Bosentan Related Compound 1;Bosentan Related CoMpound D;Intermediate of Bosentan (I);Bosentan USP Related Compound D;2,2'-Bipyrimidine,4,6-dichloro-5-(2-methoxyphenox;4,6-dichloro-5-(methoxyphenoxy)-2,2'-bipyrimidine
CBNumber: CB0511409
Molecular Formula: C15H10Cl2N4O2
Formula Weight: 349.17
MOL File: 150728-13-5.mol

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4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine Property

Melting point:: 157.0 to 161.0 °C
Boiling point:: 520.7±60.0 °C(Predicted)
Density: 1.418±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: -3.58±0.33(Predicted)
form: Solid
color: White to Light Brown
InChI: InChI=1S/C15H10Cl2N4O2/c1-22-9-5-2-3-6-10(9)23-11-12(16)20-15(21-13(11)17)14-18-7-4-8-19-14/h2-8H,1H3
InChIKey: IZGOBGVYADHVKH-UHFFFAOYSA-N
SMILES: C1(C2=NC=CC=N2)=NC(Cl)=C(OC2=CC=CC=C2OC)C(Cl)=N1
CAS DataBase Reference: 150728-13-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
HS Code: 2935909550

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D4598
Product name: 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine
Purity: >98.0%(GC)(N)
Packaging: 1g
Price: $33
Updated: 2025/07/31

TCI Chemical

Product number: D4598
Product name: 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine
Purity: >98.0%(GC)(N)
Packaging: 5g
Price: $94
Updated: 2025/07/31

TRC

Product number: D434910
Product name: 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2’-bipyrimidine
Packaging: 10g
Price: $215
Updated: 2021/12/16

Chem-Impex

Product number: 44859
Product name: 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine,≥98%(GC)
Purity: ≥98%(GC)
Packaging: 1G
Price: $45.27
Updated: 2021/12/16

Apolloscientific

Product number: OR17833
Product name: 4,6-Dichloro-5-(2-methoxyphenoxy)-[2,2']-bipyrimidine
Purity: 98%
Packaging: 1g
Price: $89
Updated: 2021/12/16

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4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine Chemical Properties,Usage,Production

Chemical Properties

Brown solid

Uses

Bosentan USP Related Compound D

Synthesis

150728-12-4

150728-13-5

General procedure for the synthesis of 4,6-dichloro-5-(2-methoxyphenoxy)-[2,2'-dipyrimidin]-4,6(1H,5H)-dione from 5-(2-methoxyphenoxy)-[2,2'-dipyrimidin]: Example of implementation: 1. 343.70 g of phosphoryl chloride was added to a reactor followed by 175.0 g of 5-(2-methoxyphenoxy)-[2,2'-dipyrimidin]-4,6(1H,5H)-dione (Compound 1). 2. The reaction mixture was heated to reflux temperature and stirred under reflux conditions for 4.0 hours. The reaction process was monitored by HPLC. 3. Upon completion of the reaction, the reaction mixture was slowly cooled to 40-50 °C. The reaction mixture was then cooled at 5-10 °C. The reaction mixture was then cooled at 5-10 °C. 4. The reaction mixture was quenched by slowly pouring into 2.625 liters of water at 5-10 °C. 5. the reaction mixture was continued to be stirred at 5-10 °C for 2.0 hours. 6. the reaction mixture was filtered and the wet filter cake was washed three times with 175.0 mL of water. 7. The wet filter cake was collected to give 4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-dipyrimidine (Compound 2) with a wet weight of 255 g. The reaction was carried out at 55° C. The wet filter cake was washed three times with 175.0 mL of water. 8. The wet filter cake was dried under vacuum at 55-60°C for 8.0 hours. 9. After drying, 182 g of Compound 2 was obtained in 93% yield and >98% HPLC purity.

References

[1] Patent: US2012/136015, 2012, A1. Location in patent: Page/Page column 7
[2] Patent: CN104193687, 2017, B. Location in patent: Paragraph 0133; 0134
[3] Patent: US2008/242687, 2008, A1. Location in patent: Page/Page column 32; 34
[4] Chimia, 1996, vol. 50, # 11, p. 538 - 543
[5] Bioorganic and Medicinal Chemistry Letters, 1997, vol. 7, # 17, p. 2223 - 2228

4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine Suppliers

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View Lastest Price from 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine 150728-13-5
Price: US $0.00-0.00/KG
Min. Order: 0.10000000149011612KG
Purity: 99% HPLC
Supply Ability: 2000tons
Release date: 2025-09-24

Shaanxi Dideu Medichem Co. Ltd

Product: 4,6-dichloro-5-(2-Methoxyphenoxy)2,2'-bipyriMidine 150728-13-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2025-09-23

Shaanxi Dideu New Materials Co. Ltd

Product: 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine 150728-13-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: tons
Release date: 2024-11-18

150728-13-5, 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidineRelated Search:

3-Methoxyphenethylamine 4-Methoxybenzyl cyanide 4-Methoxybenzyl alcohol Dichloroacetic acid 4-Methoxybenzoic acid p-Anisaldehyde (Trifluoromethoxy)benzene 4-Methoxybenzoyl chloride Anisole 3-Methoxyacetophenone 4-tert-Butylbenzenesulfonamide BenzenesulfonaMide, N,N'-[1,2-ethanediylbis[oxy[5-(2-Methoxyphenoxy)[2,2'-bipyriMidine]-6,4-diyl]]]bis[4-(1,1-diMethylethyl)- 4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide BenzenesulfonaMide, N-[1,6-dihydro-5-(2-Methoxyphenoxy)-6-oxo[2,2'-bipyriMidin]-4-yl]-4-(1,1-diMethylethyl)- Bosentan Related Compound 4 Bosentan Impurity 15 HCl Bosentan Related Compound 5 Bosentan

2,2'-Bipyrimidine, 4,6-dichloro-5-(2-methoxyphenoxy)-

4,6-Dich

4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine 99%

Bosentan Related Compound D (4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine)

Bosentan Related Compound D (15 mg) (4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine)

Bosentan Related CoMpound D

Bosentan Related Compound 1

Bosentan USP Related Compound D: 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine

4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine (bosentan intermediate)

Bosentan interMediate (I)

4,6-dichloro-5-(2-Methoxyphenoxy)-2-(pyriMidin-2-yl)pyriMidine

Bosentan USP RC D

2-(4,6-dichloro-5-(2-methoxyphenoxy) pyrimidin-2-yl)pyrimidine

2,2'-Bipyrimidine, 4,6-dichloro-5-(2-methoxyphenoxy)- (bosentan intermediate)

4,6-Dichloro-5-(O-Methoxyphenoxy)-2-(2-Pyrimidinyl)Pyrimidine

BOSENTAN INTERMEDIATES

2,2'-Bipyrimidine,4,6-dichloro-5-(2-methoxyphenox

4,6-Dichloro-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl

2-(5-(2-methoxyphenoxy)-4,6-dichloropyrimidin-2-yl)pyrimidine

4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine

Bosentan USP Related Compound D

4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine &gt

4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine,95%

(4,6-Dichloro-5-(2-Methoxyphenoxy)-2,2-Bipyrimidine)Q: What is (4,6-Dichloro-5-(2-Methoxyphenoxy)-2,2-Bipyrimidine) Q: What is the CAS Number of (4,6-Dichloro-5-(2-Methoxyphenoxy)-2,2-Bipyrimidine) Q: What is the storage condition of (4,6-Dichloro-5-(2-Methoxyphenoxy)-2,2-Bipyrimidine) Q: What are the applications of (4,6-Dichloro-5-(2-Methoxyphenoxy)-2,2-Bipyrimidine)

Bosentan Related Compound D (4,6-dichloro-5-(2-methoxyphenoxy)-2,2''-bipyrimidine) (1076159)

4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine Manufacturer/High quality/Best price/In stock

4,6-Dichloro-5- (2-methoxyphenyloxy) -2,2 '- Dipyrimidine

4,6-dichloro-5-(methoxyphenoxy)-2,2'-bipyrimidine

Bosentan Impurity 11(Bosentan USP Related Compound D)

Intermediate of Bosentan (I)

150728-13-5

C15H10Cl2N4O2

Aromatics

Bases & Related Reagents

Heterocycles

Nucleotides

API intermediates

pyrimidine