4-tert-Butylbenzenesulfonamide

Product Name: 4-tert-Butylbenzenesulfonamide
CAS No.: 6292-59-7
Chemical Name: 4-tert-Butylbenzenesulfonamide
Synonyms: BUTTPARK 44\03-78;Bosentan USP RC E;p-Tosylbenzylamine;Bosentan EP Impurity-E;Bosentan USP Impurity E;t-Butyl bezene sulfonamide;4-t-Butylbenzenesulfonamide;Bosentan Related Compound 2;Bosentan Related CoMpound E;4-t-Butylbenzenesulphonamide
CBNumber: CB4406783
Molecular Formula: C10H15NO2S
Formula Weight: 213.3
MOL File: 6292-59-7.mol

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4-tert-Butylbenzenesulfonamide Property

Melting point:: 136-138°C
Boiling point:: 337.2±35.0 °C(Predicted)
Density: 1.152±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Ethyl Acetate (Sparingly)
form: Solid
pka: 10.22±0.10(Predicted)
color: White to Off-White
InChIKey: KYDZEZNYRFJCSA-UHFFFAOYSA-N
CAS DataBase Reference: 6292-59-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 20/21/22
Safety Statements: 22-36/37/39
Hazard Note: Irritant
HS Code: 29350090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1076160
Product name: Bosentan Related Compound E
Packaging: 15mg
Price: $1300
Updated: 2025/07/31

TCI Chemical

Product number: B3837
Product name: 4-tert-Butylbenzenesulfonamide
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $29
Updated: 2025/07/31

TRC

Product number: B690735
Product name: 4-tert-Butylbenzenesulfonamide
Packaging: 10g
Price: $110
Updated: 2021/12/16

Matrix Scientific

Product number: 074999
Product name: 4-t-Butylbenzenesulfonamide
Purity: 95+%
Packaging: 25g
Price: $72
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140626
Product name: 4-(tert-Butyl)benzenesulfonamide
Packaging: 50g
Price: $75
Updated: 2021/12/16

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4-tert-Butylbenzenesulfonamide Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

4-tert-Butylbenzenesulfonamide is an intermediate as well as a degradation impurity of the endothelin receptor antagonist Bosentan (B675900).

Synthesis

15084-51-2

6292-59-7

A solution of 4-(tert-butyl)benzenesulfonyl chloride (2.30 g, 10.0 mmol) in dichloromethane (100 mL) was added to a 500 mL round bottom flask at 0 °C, followed by the slow addition of concentrated ammonia (50 mL, 100 mmol, 10 equiv). The reaction mixture was gradually warmed to room temperature and stirred continuously for 20 hours. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure and the resulting slurry was filtered through a Brinell funnel to afford 1.60 g (75% yield) of 4-(tert-butyl)benzenesulfonamide (Compound A) as a white solid.

References

[1] Chemische Berichte, 1993, vol. 126, # 7, p. 1713 - 1722
[2] Journal of Medicinal Chemistry, 2001, vol. 44, # 21, p. 3355 - 3368
[3] Patent: US2004/39033, 2004, A1. Location in patent: Page/Page column 16; 64
[4] European Journal of Medicinal Chemistry, 2004, vol. 39, # 10, p. 835 - 847
[5] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 16, p. 4397 - 4406

4-tert-Butylbenzenesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-tert-Butylbenzenesulfonamide Suppliers

Americas 1 Belgium 1 Canada 2 China 219 Europe 3 Finland 1 France 2 Germany 5 India 57 Japan 2 Slovakia 1 South Korea 1 Switzerland 3 The Netherlands 1 United Kingdom 13 United States 30 Global 342

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View Lastest Price from 4-tert-Butylbenzenesulfonamide manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-tert-Butylbenzenesulfonamide 6292-59-7
Price: US $0.00-0.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-25

Henan Fengda Chemical Co., Ltd

Product: 4-tert-Butylbenzenesulfonamide 6292-59-7
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-25

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: 4-tert-Butylbenzenesulfonamide 6292-59-7
Price: US $28.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1 ton
Release date: 2021-12-13

6292-59-7, 4-tert-ButylbenzenesulfonamideRelated Search:

N-n-Butyl benzene sulfonamide 4-tert-Butylbenzoyl chloride Methyl 4-tert-butylbenzoate tert-Butyl methyl ether Benzenesulfonamide Sulfanilamide 3-Aminobenzenesulfonamide 4-tert-Butylphenol tert-Butanol 4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine BenzenesulfonaMide, N,N'-[1,2-ethanediylbis[oxy[5-(2-Methoxyphenoxy)[2,2'-bipyriMidine]-6,4-diyl]]]bis[4-(1,1-diMethylethyl)- BenzenesulfonaMide, N-[1,6-dihydro-5-(2-Methoxyphenoxy)-6-oxo[2,2'-bipyriMidin]-4-yl]-4-(1,1-diMethylethyl)- Bosentan Related Compound 4 Bosentan Related Compound 5 Bosentan Impurity 15 HCl 2-Bromo-N-tert-butylbenzenesulfonamide Recombinant Human Telomerase

BUTTPARK 44\03-78

4-TERT-BUTYLBENZENESULFONAMIDE

4-TERT-BUTYLBENZENESULPHONAMIDE

4-(TERT-BUTYL)BENZENE-1-SULFONAMIDE

P-TERT-BUTYL-BENZENESULFONAMIDE

TertiaryButylBenzeneSulphonamide

4-(1,1-DIMETHYLETHYL)BENZENESULFONAMIDE

4-TERT-BUTYLBENZENESULFONAMIDE (SEE 5062)

4-t-Butylbenzenesulphonamide

Bosentan USP RC E

4-t-Butylbenzenesulfonamide

Bosentan Related Compound 2

Bosentan Related Compound E (15 mg) (4-(tert-butyl)benzenesulfonamide)

Tert-butyl benzene sulfonamide

t-Butyl bezene sulfonamide

Bosentan USP Related Compound E: 4-(tert-Butyl)benzenesulfonamide

4-Tertiarybutylbenzene sulphonamine

Bosentan Related CoMpound E

4-tert-Butylbenzenesulfomide

Bosentan USP Related Compound E

Tert. Butyl Benzene Sulphonamide

4-tert-Butylbenzenesulfonamide &gt

Benzenesulfonamide, 4-(1,1-dimethylethyl)-

4-tert-Butylbenzenesulfonamide ISO 9001：2015 REACH

4-(tert-Butyl)benzene-1-sulfonamideQ: What is 4-(tert-Butyl)benzene-1-sulfonamide Q: What is the CAS Number of 4-(tert-Butyl)benzene-1-sulfonamide Q: What is the storage condition of 4-(tert-Butyl)benzene-1-sulfonamide Q: What are the applications of 4-(tert-Butyl)benzene-1-sulfonamide

Bosentan Related Compound E (4-(tert-butyl)benzenesulfonamide) (1076160)

4-Tertiarybutylbenzene sulphonamide

Bosentan Impurity 12(Bosentan USP Related Compound E)

Bosentan USP Impurity E

4-TERT-BUTYLBENZENESULFONAMIDE–98%

Bosentan EP Impurity-E

p-Tosylbenzylamine

6292-59-7

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