ChemicalBook > CAS DataBase List > 4,6-Dichloro-2-methylpyrimidine

4,6-Dichloro-2-methylpyrimidine

Product Name: 4,6-Dichloro-2-methylpyrimidine
CAS No.: 1780-26-3
Chemical Name: 4,6-Dichloro-2-methylpyrimidine
Synonyms: 6-Dichloro-2-methylpyrimidine;2-METHYL-4,6-DICHLOROPYRIMIDINE;Pyrimidine, 4,6-dichloro-2-methyl-;2-MDCP;BUTTPARK 52\14-70;4,6-Dichloro-2-methy;Dasatinib Impurity 99;Dasatinib EP Impurity-B;4,6-Dicloro-2-methylpyrimidine;4,6-DICHLORO-2-METHYLPYRIMIDINE
CBNumber: CB2176132
Molecular Formula: C5H4Cl2N2
Formula Weight: 163
MOL File: 1780-26-3.mol

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4,6-Dichloro-2-methylpyrimidine Property

Melting point:: 41.5-45.5 °C (lit.)
Boiling point:: 210.8±20.0 °C(Predicted)
Density: 1.404±0.06 g/cm3(Predicted)
Flash point:: 208 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
pka: -3.84±0.30(Predicted)
form: Crystalline Powder or Crystals
color: White to off-white
InChI: InChI=1S/C5H4Cl2N2/c1-3-8-4(6)2-5(7)9-3/h2H,1H3
InChIKey: FIMUTBLUWQGTIJ-UHFFFAOYSA-N
SMILES: C1(C)=NC(Cl)=CC(Cl)=N1
CAS DataBase Reference: 1780-26-3(CAS DataBase Reference)

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Safety

Hazard Codes: C,N,Xn
Risk Statements: 34-51/53-43-22
Safety Statements: 26-36/37/39-45-61-36/37
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
HazardClass: 8
PackingGroup: III
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 596728
Product name: 4,6-Dichloro-2-methylpyrimidine
Purity: 98%
Packaging: 5g
Price: $21.36
Updated: 2025/07/31

Sigma-Aldrich

Product number: 596728
Product name: 4,6-Dichloro-2-methylpyrimidine
Purity: 98%
Packaging: 25g
Price: $99.5
Updated: 2025/07/31

TCI Chemical

Product number: D3558
Product name: 4,6-Dichloro-2-methylpyrimidine
Purity: >98.0%(GC)
Packaging: 5g
Price: $30
Updated: 2025/07/31

TCI Chemical

Product number: D3558
Product name: 4,6-Dichloro-2-methylpyrimidine
Purity: >98.0%(GC)
Packaging: 25g
Price: $120
Updated: 2025/07/31

Usbiological

Product number: 161620
Product name: 4,6-Dichloro-2-methylpyrimidine
Packaging: 5g
Price: $403
Updated: 2021/12/16

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4,6-Dichloro-2-methylpyrimidine Chemical Properties,Usage,Production

Chemical Properties

White to off-white solid

Uses

4,6-Dichloro-2-methylpyrimidine, is a versatile building block used for the synthesis of more complex pharmaceutical and biologically active compounds, such as Dasatinib (D290002), and its derivatives.

Synthesis

1194-22-5

1780-26-3

General procedure for the synthesis of 4,6-dichloro-2-methylpyrimidine from 6-hydroxy-2-methylpyrimidin-4-one: 4,6-dihydroxy-2-methylpyrimidine (5.0 g, 0.04 mol) was added to a mixed solution of thionyl chloride (18.9 g, 0.16 mol) with acetonitrile. The reaction mixture was stirred at 80 °C for 3 h and the completion of the reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, excess thionyl chloride was removed by distillation under reduced pressure and the residue was slowly poured into 50 g of ice water. The precipitated solid was filtered and purified by column chromatography to give 6.1 g (yield: 94%) of 4,6-dichloro-2-methylpyrimidine as a white solid.

References

[1] Tetrahedron Letters, 2009, vol. 50, # 41, p. 5729 - 5732
[2] Patent: CN106478519, 2017, A. Location in patent: Paragraph 0020-0023; 0030-0032; 0038-0040; 0049-0052
[3] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 11, p. 2969 - 2973
[4] Tetrahedron, 2006, vol. 62, # 10, p. 2304 - 2312
[5] Patent: WO2004/46133, 2004, A1. Location in patent: Page 40-41

4,6-Dichloro-2-methylpyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

Moxonidine

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4,6-Dichloro-2-methylpyrimidine Suppliers

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View Lastest Price from 4,6-Dichloro-2-methylpyrimidine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 4,6-Dichloro-2-methylpyrimidine 1780-26-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-19

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4,6-Dichloro-2-methylpyrimidine 1780-26-3
Price: US $25.00/ASSAYS
Min. Order: 100ASSAYS
Purity: 99.5%
Supply Ability: 100 mt
Release date: 2025-03-10

Henan Aochuang Chemical Co.,Ltd.

Product: 4,6-Dichloro-2-methylpyrimidine 1780-26-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-10

1780-26-3, 4,6-Dichloro-2-methylpyrimidineRelated Search:

Dichloromethylsilane Dichloroacetic acid 4,6-Dihydroxypyrimidine 4-Ethyl-5-fluoro-6-hydroxypyrimidine Pirimiphos-methyl 2-Chloro-5-chloromethylpyridine 4,6-Dichloropyrimidine 2-Methylpyrimidine Dichloromethylphenylsilane Dichlorodimethylsilane 4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE 4,6-Dichloro-2-(methylthio)pyrimidine 4,7-Dichloro-6-nitroquinazoline Furo[2,3-d]pyridazine, 4,7-dichloro 4,6-DICHLORO-5-NITRO-2-PROPYLTHIOPYRIMIDINE 4,6-dichloro-2-propylthiopyrimidine-5-amine 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine 4,6-Dichloro-2-methyl-5-nitropyrimidine

BUTTPARK 52\14-70

2-MDCP

2-METHYL-4,6-DICHLOROPYRIMIDINE

4,6-DICHLORO-2-METHYLPYRIMIDINE

4,6-Dichloro-2-methylpyrimidiine

Pyrimidine, 4,6-dichloro-2-methyl-

4,6-Dichloro-2-methylpyrimidine ,99%

4,6-Dichloro-2-Methylpyrimidine/2,4-dichloro-6-methylpyrimidine

6-Dichloro-2-methylpyrimidine

4,6-Dichloro-2-methy

4,6-Dichloro-2-methylpyrimidine 98%

4,6-Dichloro-2-methylpyrimidine&gt

4,6-Dichloro-2-methylpyrimidine ISO 9001：2015 REACH

2-METHYL-4,6-DICHLORO?PYRMIDINE

Dasatinib Impurity 99

4,6-Dicloro-2-methylpyrimidine

Dasatinib EP Impurity-B

1780-26-3

C5H4N2Cl2

Pyrimidines

Heterocyclic Building Blocks

Halogenated Heterocycles

Building Blocks

Heterocycle-Pyrimidine series

alkyl chloride

Pyrimidines

APIs & Intermediate

Pyrimidine

Halides

Pyrazines, Pyrimidines & Pyridazines

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

PyrimidinesHeterocyclic Building Blocks

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