5-Amino-4,6-dichloro-2-methylpyrimidine

Appearance

Product Name: 5-Amino-4,6-dichloro-2-methylpyrimidine
CAS No.: 39906-04-2
Chemical Name: 5-Amino-4,6-dichloro-2-methylpyrimidine
Synonyms: TIMTEC-BB SBB003764;2-Methyl-4,6-dichloro-5-aminop;Methyl-4,6-dichloro-5-aminopyrimidine;4,6-DICHLORO-2-METHYLPYRIMIDIN-5-AMINE;4,6-dichloro-2-methyl-5-pyrimidinamine;5-AMINO-4,6-DICHLORO-2-METHYLPYRIMIDINE;2-METHYL-4,6-DICHLORO-5-AMINOPYRIMIDINE;5-Amino-4,6-Dichloro-2-Methylpytimidine;4,6-dichloro-2-Methyl-5-aMino-pyriMidine;5-Pyrimidinamine, 4,6-dichloro-2-methyl-
CBNumber: CB9368291
Molecular Formula: C5H5Cl2N3
Formula Weight: 178.02
MOL File: 39906-04-2.mol

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5-Amino-4,6-dichloro-2-methylpyrimidine Property

Melting point:: 70-73 °C (lit.)
Boiling point:: 257.7±35.0 °C(Predicted)
Density: 1.504±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: -2.55±0.39(Predicted)
color: White to Yellow to Green
InChI: InChI=1S/C5H5Cl2N3/c1-2-9-4(6)3(8)5(7)10-2/h8H2,1H3
InChIKey: FKRXXAMAHOGYNT-UHFFFAOYSA-N
SMILES: C1(C)=NC(Cl)=C(N)C(Cl)=N1
CAS DataBase Reference: 39906-04-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 548235
Product name: 5-Amino-4,6-dichloro-2-methylpyrimidine
Purity: 97%
Packaging: 10g
Price: $119
Updated: 2023/06/20

TCI Chemical

Product number: A1946
Product name: 5-Amino-4,6-dichloro-2-methylpyrimidine
Purity: >98.0%(GC)
Packaging: 5g
Price: $121
Updated: 2025/07/31

TCI Chemical

Product number: A1946
Product name: 5-Amino-4,6-dichloro-2-methylpyrimidine
Purity: >98.0%(GC)
Packaging: 25g
Price: $481
Updated: 2025/07/31

TRC

Product number: A632035
Product name: 5-Amino-4,6-dichloro-2-methylpyrimidine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA11120
Product name: 5-Amino-4,6-dichloro-2-methylpyrimidine
Packaging: 25g
Price: $60
Updated: 2021/12/16

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5-Amino-4,6-dichloro-2-methylpyrimidine Chemical Properties,Usage,Production

Appearance

White to Yellow to Green powder to crystal

Uses

5-Amino-4,6-dichloro-2-methylpyrimidine is a useful research chemical for organic synthesis and other chemical and pharmacological processes.

Application

5-Amino-4,6-dichloro-2-methylpyrimidine can be used as an intermediate in medical synthesis, such as the preparation of mosonidine. Mosonidine is a widely used antihypertensive drug.

Synthesis

13162-43-1

39906-04-2

GENERAL METHOD: 10% Pd/C catalyst (0.05 g) was added to a solution of 4,6-dichloro-2-methyl-5-nitropyrimidine (4.48 mmol) in ethyl acetate (EA, 20 mL) in a Parr hydrogenation reactor. Subsequently, the air in the reactor was replaced with nitrogen three times and the hydrogenation reaction was carried out at room temperature and at atmospheric pressure. Upon completion of the reaction, the Pd/C catalyst was removed by diatomaceous earth filtration and the filtrate was concentrated to afford the intermediate 2-methyl-4,6-dichloro-5-aminopyrimidine (11a). The product was a light-colored solid, yield: 84.0%; mass spectrum (ESI) m/z: 177.94 [M + H]+.

References

[1] European Journal of Medicinal Chemistry, 2017, vol. 140, p. 212 - 228
[2] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983, p. 1113 - 1115
[3] Khimiya Geterotsiklicheskikh Soedinenii, 1983, vol. 19, # 10, p. 1398 - 1400
[4] Journal of the Chemical Society, 1954, p. 3832,3833
[5] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 17, p. 5721 - 5726

5-Amino-4,6-dichloro-2-methylpyrimidine Preparation Products And Raw materials

Raw materials

4,6-Dihydroxy-2-methylpyrimidine Sodium chloride Toluene Trifluoroacetic acid Phosphorus oxitrichloride Diethylamine Diisopropylamine Diethyl ether Ethyl acetate Nitric acid Acetic acid Methanol Sodium hydroxide Iron Magnesium sulfate Malonic acid

Preparation Products

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5-Amino-4,6-dichloro-2-methylpyrimidine Suppliers

Americas 1 China 222 Czech Republic 1 Europe 3 Germany 3 India 12 Japan 2 Slovakia 1 Switzerland 1 Ukraine 1 United Kingdom 12 United States 32 Global 291

Hubei Chuangliankangcheng Pharmaceutical Co., Ltd.

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Energy Chemical

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View Lastest Price from 5-Amino-4,6-dichloro-2-methylpyrimidine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 5-Amino-4,6-dichloro-2-methylpyrimidine 39906-04-2
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 500kgs
Release date: 2021-09-16

Henan Aochuang Chemical Co.,Ltd.

Product: 5-Amino-4,6-dichloro-2-methylpyrimidine 39906-04-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-28

Henan Fengda Chemical Co., Ltd

Product: 5-Amino-4,6-dichloro-2-methylpyrimidine 39906-04-2
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-16

39906-04-2, 5-Amino-4,6-dichloro-2-methylpyrimidineRelated Search:

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2-METHYL-4,6-DICHLORO-5-AMINOPYRIMIDINE

TIMTEC-BB SBB003764

5-AMINO-4,6-DICHLORO-2-METHYLPYRIMIDINE

4,6-DICHLORO-2-METHYLPYRIMIDIN-5-AMINE

4,6-DICHLORO-2-METHYL-PYRIMIDIN-5-YLAMINE

2-Methyl-4,6-dichloro-5-aminop

2-methyl-4,6-dichloro-5-aminopyrimidine (intermediate of moxonidine hcl)

5-Amino-4,6-Dichloro-2-Methylpytimidine

4,6-Dichloro-2-methylpyrimidin-5-amine, 5-Amino-4,6-dichloro-2-methyl-1,3-diazine

4,6-dichloro-2-Methyl-5-aMino-pyriMidine

5-Amino-4,6-dichloro-2-methylpyrimidine 97%

Methyl-4,6-dichloro-5-aminopyrimidine

4,6-dichloro-2-methyl-5-pyrimidinamine

5-Amino-4,6-dichloro-2-methylpyrimidine &gt

5-Pyrimidinamine, 4,6-dichloro-2-methyl-

2-METHYL-4,6-DICHLORO-5-AMINOPYRIMIDINE 39906-04-2

5-Amino-4,6-dichloro-2-methylpyrimidine USP/EP/BP

39906-04-2

C5H5N3Cl2

Heterocyclic Building Blocks

Halogenated Heterocycles

Pyrimidines

Building Blocks

Pyridines, Pyrimidines, Purines and Pteredines

Pyrimidine

(intermediate of moxonidine hcl)

(intermediate of moxonidine)

39906-04-2

OLED