Terazosin
- Product Name
- Terazosin
- CAS No.
- 63590-64-7
- Chemical Name
- Terazosin
- Synonyms
- Urodie;HYTRIN;erazosin;arbonyl)-;Terazosin;terazosine;CID 663211;TERAZOSIN HCL;Vasomet：Vicard;Hytrin：Hytrinex
- CBNumber
- CB2285511
- Molecular Formula
- C19H25N5O4
- Formula Weight
- 387.43
- MOL File
- 63590-64-7.mol
Terazosin Property
- Melting point:
- 281-283°C
- Boiling point:
- 664.5±65.0 °C(Predicted)
- Density
- 1.332±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- H2O: 25 mg/mL
- form
- powder
- pka
- pKa (0.1N NaOH): 7.1(at 25℃)
- color
- white to off-white
- Water Solubility
- 30.6mg/L(22.5 ºC)
- BCS Class
- 1/3
- InChIKey
- VCKUSRYTPJJLNI-UHFFFAOYSA-N
- CAS DataBase Reference
- 63590-64-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- RTECS
- TK8044925
N-Bromosuccinimide Price
- Product number
- 466982
- Product name
- Terazosin
- Packaging
- 1mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- FA28036
- Product name
- 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonxyl]piperazine hydrochloride
- Packaging
- 100g
- Price
- $500
- Updated
- 2021/12/16
- Product number
- API0005881
- Product name
- TERAZOSIN
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $693
- Updated
- 2021/12/16
- Product number
- 13666
- Product name
- TerazosinHCl
- Packaging
- 1g
- Price
- $850
- Updated
- 2021/12/16
- Product number
- FA28036
- Product name
- 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonxyl]piperazine hydrochloride
- Packaging
- 5G
- Price
- $100
- Updated
- 2021/12/16
Terazosin Chemical Properties,Usage,Production
Chemical Properties
White to Off-White Crystalline Powder
Uses
An α-1-adrenergicblocker related to prazosin.
Uses
Terazosin is used for the same indications as is prazosin; however, it has the advantage of being able to be used once a day.
Uses
An a-1-adrenergicblocker related to prazosin
Definition
ChEBI: Terazosin is a member of quinazolines, a member of piperazines, a member of furans and a primary amino compound. It has a role as an antineoplastic agent, an antihypertensive agent and an alpha-adrenergic antagonist.
Clinical Use
Alpha-adrenoceptor blocker:
Hypertension
Benign prostatic hyperplasia (BPH)
Synthesis
Terazosin, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)- piperazine (12.2.13), only differs from prazosin in that the furyl radical is replaced with a tetrahydrofuryl radical. It is synthesized in exactly the same manner except using 1-(2-tetrahydrofuroyl)piperazine instead of 1-(2-furoyl)piperazine [48–51].
Drug interactions
Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Antidepressants: enhanced hypotensive effect with
MAOIs.
Avanafil, vardenafil, sildenafil and tadalafil: enhanced
hypotensive effect - avoid concomitant use.
Beta-blockers: enhanced hypotensive effect;
increased risk of first dose hypotensive effect.
Calcium-channel blockers: enhanced hypotensive
effect; increased risk of first dose hypotensive effect.
Diuretics: enhanced hypotensive effect; increased
risk of first dose hypotensive effect.
Moxisylyte: possibly severe postural hypotension
when used in combination.
Metabolism
Terazosin is metabolised in the liver; one of the
metabolites has antihypertensive activity.
Terazosin is excreted in faeces via the bile, and in the
urine, as unchanged drug and metabolites.
Terazosin Preparation Products And Raw materials
Raw materials
Preparation Products
Terazosin Suppliers
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View Lastest Price from Terazosin manufacturers
- Product
- Terazosin 63590-64-7
- Price
- US $999.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1 ton
- Release date
- 2021-12-23
- Product
- Terazosin 63590-64-7
- Price
- US $19.99/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20KG
- Release date
- 2022-01-10
- Product
- Terazosin 63590-64-7
- Price
- US $15.60/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000tons
- Release date
- 2022-01-12