ChemicalBook > CAS DataBase List > Terazosin

Terazosin

Product Name
Terazosin
CAS No.
63590-64-7
Chemical Name
Terazosin
Synonyms
Urodie;HYTRIN;erazosin;arbonyl)-;Terazosin;terazosine;TERAZOSIN HCL;Vasomet:Vicard;Hytrin:Hytrinex;TERAZOSIN(HYTRIN)
CBNumber
CB2285511
Molecular Formula
C19H25N5O4
Formula Weight
387.43
MOL File
63590-64-7.mol
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Terazosin Property

Melting point:
281-283°C
Boiling point:
664.5±65.0 °C(Predicted)
Density 
1.332±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
H2O: 25 mg/mL
form 
powder
pka
pKa (0.1N NaOH): 7.1(at 25℃)
color 
white to off-white
Water Solubility 
30.6mg/L(22.5 ºC)
BCS Class
1/3
InChIKey
VCKUSRYTPJJLNI-UHFFFAOYSA-N
CAS DataBase Reference
63590-64-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
TK8044925
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Usbiological
Product number
466982
Product name
Terazosin
Packaging
1mg
Price
$460
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA28036
Product name
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonxyl]piperazine hydrochloride
Packaging
100g
Price
$500
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0005881
Product name
TERAZOSIN
Purity
95.00%
Packaging
1G
Price
$693
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
13666
Product name
TerazosinHCl
Packaging
1g
Price
$850
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA28036
Product name
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonxyl]piperazine hydrochloride
Packaging
5G
Price
$100
Updated
2021/12/16
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Terazosin Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Crystalline Powder

Uses

An α-1-adrenergicblocker related to prazosin.

Uses

Terazosin is used for the same indications as is prazosin; however, it has the advantage of being able to be used once a day.

Uses

An a-1-adrenergicblocker related to prazosin

Definition

ChEBI: Terazosin is a member of quinazolines, a member of piperazines, a member of furans and a primary amino compound. It has a role as an antineoplastic agent, an antihypertensive agent and an alpha-adrenergic antagonist.

Clinical Use

Alpha-adrenoceptor blocker:
Hypertension
Benign prostatic hyperplasia (BPH)

Synthesis

Terazosin, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)- piperazine (12.2.13), only differs from prazosin in that the furyl radical is replaced with a tetrahydrofuryl radical. It is synthesized in exactly the same manner except using 1-(2-tetrahydrofuroyl)piperazine instead of 1-(2-furoyl)piperazine [48–51].

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Antidepressants: enhanced hypotensive effect with MAOIs.
Avanafil, vardenafil, sildenafil and tadalafil: enhanced hypotensive effect - avoid concomitant use.
Beta-blockers: enhanced hypotensive effect; increased risk of first dose hypotensive effect.
Calcium-channel blockers: enhanced hypotensive effect; increased risk of first dose hypotensive effect.
Diuretics: enhanced hypotensive effect; increased risk of first dose hypotensive effect.
Moxisylyte: possibly severe postural hypotension when used in combination.

Metabolism

Terazosin is metabolised in the liver; one of the metabolites has antihypertensive activity.
Terazosin is excreted in faeces via the bile, and in the urine, as unchanged drug and metabolites.

Terazosin Preparation Products And Raw materials

Raw materials

Preparation Products

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Terazosin Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9809
Advantage
59
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8844
Advantage
52
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
GIHI CHEMICALS CO.,LTD
Tel
0086-571-86217390
Fax
0086-571-86217391
Email
Sales@gihichem.com
Country
China
ProdList
860
Advantage
58
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View Lastest Price from Terazosin manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Terazosin 63590-64-7
Price
US $999.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1 ton
Release date
2021-12-23
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Terazosin 63590-64-7
Price
US $19.99/KG
Min. Order
1KG
Purity
99%
Supply Ability
20KG
Release date
2022-01-10
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Terazosin 63590-64-7
Price
US $15.60/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000tons
Release date
2022-01-12

63590-64-7, TerazosinRelated Search:


  • 1-(4-aMino-6,7-diMethoxy-quinazolin-2-yl)-4-(tetrahydrofuran-2-carbonyl)-piperazine
  • TERAZOSIN(HYTRIN)
  • Prazosin Tetrahydro IMpurity
  • Hytrin:Hytrinex
  • Urodie
  • Vasomet:Vicard
  • 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl) carbonxyl] piperazine hydrochloride
  • 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbowl]piperazine
  • Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)-<br />
  • 1-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-4-[(tetrahydrofuran-2-yl)carbonyl]piperazine
  • [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-[(2S)-2-oxolanyl]methanone
  • Methanone,[4-(4-aMino-6,7-diMethoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)-
  • [4-(4-AMINO-6,7-DIMETHOXY-QUINAZOLIN-2-YL)PIPERAZIN-1-YL]-OXOLAN-2-YL-METHANONE
  • 1-(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)-4-[(TETRAHYDRO-2-FURANYL)CARBONXYL]PIPERAZINE, HYDROCHLORIDE
  • HYTRIN
  • TERAZOSIN MONOHYDROCHLORIDE
  • TERAZOSIN HCL
  • 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)p
  • arbonyl)-
  • terazosine
  • 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine
  • Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]- (9CI)
  • 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)4-[(tetrahydro-2-furanyl)carbonyl]piperazine
  • 6,7-Dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine hydrochloride
  • Terazosin
  • N-(2-tertrahydrofuroyl)-piperazine
  • erazosin
  • Terazosin USP/EP/BP
  • 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-{(tetnaphydro-2-furanyl)carbonyl}piperazine
  • 63590-64-7
  • C19H29ClN5O6
  • C19H26ClN5O4
  • C19H28ClN5O6
  • C19H25N5O4
  • API's
  • API
  • Terazosin
  • Intermediates & Fine Chemicals
  • Pharmaceuticals