Terazosin

ChemicalBook > CAS DataBase List > Terazosin

Product Name: Terazosin
CAS No.: 63590-64-7
Chemical Name: Terazosin
Synonyms: Urodie;HYTRIN;erazosin;arbonyl)-;Terazosin;terazosine;CID 663211;TERAZOSIN HCL;Vasomet：Vicard;Hytrin：Hytrinex
CBNumber: CB2285511
Molecular Formula: C19H25N5O4
Formula Weight: 387.43
MOL File: 63590-64-7.mol

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Terazosin Property

Melting point:: 281-283°C
Boiling point:: 664.5±65.0 °C(Predicted)
Density: 1.332±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: H₂O: 25 mg/mL
form: powder
pka: pKa (0.1N NaOH): 7.1(at 25℃)
color: white to off-white
Water Solubility: 30.6mg/L(22.5 ºC)
BCS Class: 1/3
InChIKey: VCKUSRYTPJJLNI-UHFFFAOYSA-N
CAS DataBase Reference: 63590-64-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: TK8044925

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed
Precautionary statements: P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Usbiological

Product number: 466982
Product name: Terazosin
Packaging: 1mg
Price: $460
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA28036
Product name: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonxyl]piperazine hydrochloride
Packaging: 100g
Price: $500
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0005881
Product name: TERAZOSIN
Purity: 95.00%
Packaging: 1G
Price: $693
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 13666
Product name: TerazosinHCl
Packaging: 1g
Price: $850
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA28036
Product name: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonxyl]piperazine hydrochloride
Packaging: 5G
Price: $100
Updated: 2021/12/16

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Terazosin Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Crystalline Powder

Uses

An α-1-adrenergicblocker related to prazosin.

Uses

Terazosin is used for the same indications as is prazosin; however, it has the advantage of being able to be used once a day.

Uses

An a-1-adrenergicblocker related to prazosin

Definition

ChEBI: Terazosin is a member of quinazolines, a member of piperazines, a member of furans and a primary amino compound. It has a role as an antineoplastic agent, an antihypertensive agent and an alpha-adrenergic antagonist.

Clinical Use

Alpha-adrenoceptor blocker:
Hypertension
Benign prostatic hyperplasia (BPH)

Synthesis

Terazosin, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)- piperazine (12.2.13), only differs from prazosin in that the furyl radical is replaced with a tetrahydrofuryl radical. It is synthesized in exactly the same manner except using 1-(2-tetrahydrofuroyl)piperazine instead of 1-(2-furoyl)piperazine [48–51].

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Antidepressants: enhanced hypotensive effect with MAOIs.
Avanafil, vardenafil, sildenafil and tadalafil: enhanced hypotensive effect - avoid concomitant use.
Beta-blockers: enhanced hypotensive effect; increased risk of first dose hypotensive effect.
Calcium-channel blockers: enhanced hypotensive effect; increased risk of first dose hypotensive effect.
Diuretics: enhanced hypotensive effect; increased risk of first dose hypotensive effect.
Moxisylyte: possibly severe postural hypotension when used in combination.

Metabolism

Terazosin is metabolised in the liver; one of the metabolites has antihypertensive activity.
Terazosin is excreted in faeces via the bile, and in the urine, as unchanged drug and metabolites.

Terazosin Preparation Products And Raw materials

Raw materials

2-Furoic acid Piperazine Quinazoline 2-Furoyl chloride Terazosin hydrochloride

Preparation Products

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View Lastest Price from Terazosin manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Terazosin 63590-64-7
Price: US $999.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1 ton
Release date: 2021-12-23

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Terazosin 63590-64-7
Price: US $19.99/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20KG
Release date: 2022-01-10

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Terazosin 63590-64-7
Price: US $15.60/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000tons
Release date: 2022-01-12

63590-64-7, TerazosinRelated Search:

Piperacillin Dimethyldimethoxysilane N-Aminoethylpiperazine Tris(hydroxymethyl)aminomethane 6-Aminocaproic acid Diphenyldimethoxysilane CARBONYL SULFIDE Glycine 3-Aminophenol ALTRENOGEST 1,1-Dimethoxyethane PYRAZOPHOS Terazosin hydrochloride TERAZOSIN RELATED COMPOUND C (25 MG) (1,4-BIS(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)PIPER-AZINE DIHYDROCHLORIDE) TERAZOSIN RELATED COMPOUND B (50 MG) (1-(4-HYDROXY-6,7-DIMETHOXY-2-QUINAZOLINYL)-4-[(TETRA-HYDRO-2-FURANYL)CARBONYL]PIPERAZINE) Terazosin hydrochloride dihydrate 2-chloro-4-amino-6,7-dimethoxyquinazoline (intermediate of terazosin) Quinazoline

1-(4-aMino-6,7-diMethoxy-quinazolin-2-yl)-4-(tetrahydrofuran-2-carbonyl)-piperazine

TERAZOSIN(HYTRIN)

Prazosin Tetrahydro IMpurity

Hytrin：Hytrinex

Urodie

Vasomet：Vicard

1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl) carbonxyl] piperazine hydrochloride

1-(4-Amino-6，7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbowl]piperazine

Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)-<br />

1-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-4-[(tetrahydrofuran-2-yl)carbonyl]piperazine

[4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-[(2S)-2-oxolanyl]methanone

Methanone,[4-(4-aMino-6,7-diMethoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)-

[4-(4-AMINO-6,7-DIMETHOXY-QUINAZOLIN-2-YL)PIPERAZIN-1-YL]-OXOLAN-2-YL-METHANONE

1-(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)-4-[(TETRAHYDRO-2-FURANYL)CARBONXYL]PIPERAZINE, HYDROCHLORIDE

HYTRIN

TERAZOSIN MONOHYDROCHLORIDE

TERAZOSIN HCL

1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)p

arbonyl)-

terazosine

1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine

Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]- (9CI)

1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)4-[(tetrahydro-2-furanyl)carbonyl]piperazine

6,7-Dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine hydrochloride

Terazosin

N-(2-tertrahydrofuroyl)-piperazine

erazosin

Terazosin USP/EP/BP

1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-{(tetnaphydro-2-furanyl)carbonyl}piperazine

CID 663211

63590-64-7

C19H29ClN5O6

C19H26ClN5O4

C19H28ClN5O6

C19H25N5O4

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Terazosin

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