3'-Chloroacetophenone
Uses- Product Name
- 3'-Chloroacetophenone
- CAS No.
- 99-02-5
- Chemical Name
- 3'-Chloroacetophenone
- Synonyms
- 1-(3-Chlorophenyl)ethan-1-one;1-(3-CHLOROPHENYL)ETHANONE;3-CHLOROACETOPHENONE;M-CHLOROACETOPHENONE;3'-Chloroacetophenon;3'-Chloroacetophenone;3'-Chloroacetylphenone;3a€?-Chloroacetophenone;1-Acetyl-3-chlorobenzene;3'-Chloroacetyl chloride
- CBNumber
- CB4667827
- Molecular Formula
- C8H7ClO
- Formula Weight
- 154.59
- MOL File
- 99-02-5.mol
3'-Chloroacetophenone Property
- Boiling point:
- 227-229 °C(lit.)
- Density
- 1.191 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.550(lit.)
- Flash point:
- 221 °F
- storage temp.
- Sealed in dry,Room Temperature
- form
- Liquid
- Specific Gravity
- 1.191
- color
- Clear colorless to yellow
- Sensitive
- Lachrymatory
- BRN
- 636318
- InChI
- InChI=1S/C8H7ClO/c1-6(10)7-3-2-4-8(9)5-7/h2-5H,1H3
- InChIKey
- UUWJBXKHMMQDED-UHFFFAOYSA-N
- SMILES
- C(=O)(C1=CC=CC(Cl)=C1)C
- CAS DataBase Reference
- 99-02-5(CAS DataBase Reference)
- NIST Chemistry Reference
- Acetophenone, 3'-chloro-(99-02-5)
- EPA Substance Registry System
- Ethanone, 1-(3-chlorophenyl)- (99-02-5)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-36-20/21/22
- Safety Statements
- 26-36-37/39-36/37/39-13-7/9
- RIDADR
- UN 3416 6.1/PG 2
- WGK Germany
- 3
- F
- 19
- Hazard Note
- Harmful/Irritant/Lachrymatory
- TSCA
- TSCA listed
- HazardClass
- 6.1
- PackingGroup
- II
- HS Code
- 29147090
- Storage Class
- 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials - Hazard Classifications
- Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 288799
- Product name
- 3′-Chloroacetophenone
- Purity
- 98%
- Packaging
- 5g
- Price
- $26.8
- Updated
- 2025/07/31
- Product number
- 288799
- Product name
- 3′-Chloroacetophenone
- Purity
- 98%
- Packaging
- 25g
- Price
- $31.1
- Updated
- 2025/07/31
- Product number
- C0096
- Product name
- 3'-Chloroacetophenone
- Purity
- >97.0%(GC)
- Packaging
- 10mL
- Price
- $36
- Updated
- 2025/07/31
- Product number
- C0096
- Product name
- 3'-Chloroacetophenone
- Purity
- >97.0%(GC)
- Packaging
- 25mL
- Price
- $71
- Updated
- 2025/07/31
- Product number
- C363260
- Product name
- 3’-Chloroacetophenone
- Packaging
- 250g
- Price
- $440
- Updated
- 2021/12/16
3'-Chloroacetophenone Chemical Properties,Usage,Production
Uses
3'-Chloroacetophenone can be used as a raw material for pharmaceutical synthesis, mainly for the synthesis of carbamazepine, a drug for the treatment of epilepsy, and as an intermediate for fine chemicals, pesticides, etc.
Chemical Properties
clear colourless to yellow liquid
Uses
3’-Chloroacetophenone is usd in the synthesis of GABA-AT inhibitors. Also used in the synthesis of antimycobacterial studies.
Synthesis Reference(s)
The Journal of Organic Chemistry, 60, p. 2361, 1995 DOI: 10.1021/jo00113a013
General Description
The activity of strain, Saccharomyces cerevisiae B5, on the reduction of 3′-chloroacetophenone was studied.
Synthesis
The first step of the reaction is to use anhydrous ether as solvent, carbon tetrachloride as initiating catalyst, from magnesium, anhydrous ethanol and diethyl malonate, at atmospheric pressure and 20 ~ 35 , heating reflux for 2 ~ 4 hours, while the preparation of magnesium ethoxymalonate malonate diethyl ester, the conversion rate of diethyl malonate can reach 85% to 90%; the second step of the reaction is to use anhydrous ether as solvent, at atmospheric pressure and temperature 30 ~ 35 , and The second step reaction is to use anhydrous ether as solvent, at atmospheric pressure and temperature 30 ~ 35 , by the magnesium ethoxide malonate and m-chlorobenzoyl malonate reaction to generate m-chlorobenzoyl malonate, m-chlorobenzoyl conversion rate of 90%, the selectivity of up to 85%; the third step reaction is in the aqueous sulfuric acid solution, under atmospheric pressure and temperature of 90 ~ 110 , heated reflux for 3-5 hours by the hydrolysis and decarboxylation of m-chlorobenzoyl malonate and m-chlorophenyl acetophenone generation, hydrolysis and decarboxylation rate of almost 100%. The hydrolysis and decarboxylation rate was almost 100%. After hydrolysis and decarboxylation, the reaction mixture is separated by distillation, and m-chloroacetophenone with content 99% can be obtained, and the yield of the product can be up to 75%85%.
3'-Chloroacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
3'-Chloroacetophenone Suppliers
- Tel
- 13969917693 13776793199
- 2246953955@qq.com
- Country
- China
- ProdList
- 12
- Advantage
- 58
- Tel
- 130-0567-0367 13006570367
- 3429531746@qq.com
- Country
- China
- ProdList
- 2456
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 010-60275820 13031183356
- Fax
- 010-60270825
- elainezt@sina.com
- Country
- China
- ProdList
- 1390
- Advantage
- 62
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44802
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 11776
- Advantage
- 60
View Lastest Price from 3'-Chloroacetophenone manufacturers
- Product
- 3'-Chloroacetophenone 99-02-5
- Price
- US $200.00-95.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-04-24
- Product
- 3'-Chloroacetophenone 99-02-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000KG
- Release date
- 2024-08-25
- Product
- 3'-Chloroacetophenone 99-02-5
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-08-15