2,4-Dichloro-5-fluoroacetophenone

Application

Product Name: 2,4-Dichloro-5-fluoroacetophenone
CAS No.: 704-10-9
Chemical Name: 2,4-Dichloro-5-fluoroacetophenone
Synonyms: 2,4-Dichloro-5-fluor;2,4-dichloro-5-fluoroben;Ciprofloxacin Impurity 18;2',4'-Dichloro-5'-Fluoroacet;2,4- Dichloro -5-fluorohypnone;2,4-DICHLORO-5-FLUOROACETOPHENONE;2,4-Dichloro-5-flouroacetophenone;2,4-Dichloro-5-fluorobenzophenone;2',4'-DICHLORO-5'-FLUOROACETOPHENONE;2,4- twochlorine-5- fluoroAcetophenone
CBNumber: CB6118080
Molecular Formula: C8H5Cl2FO
Formula Weight: 207.03
MOL File: 704-10-9.mol

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2,4-Dichloro-5-fluoroacetophenone Property

Melting point:: 33-36 °C
Boiling point:: 167 °C(lit.)
Density: 1.425 g/mL at 25 °C(lit.)
refractive index: n20/D 1.546(lit.)
Flash point:: >230 °F
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
color: White to Almost white
Specific Gravity: 1.425
BRN: 3090042
InChI: InChI=1S/C8H5Cl2FO/c1-4(12)5-2-8(11)7(10)3-6(5)9/h2-3H,1H3
InChIKey: FAKJFAMIABOKBW-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC(F)=C(Cl)C=C1Cl)C
CAS DataBase Reference: 704-10-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,F
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
Hazard Note: Flammable
HazardClass: IRRITANT
HS Code: 29147000
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 457345
Product name: 2′,4′-Dichloro-5′-fluoroacetophenone
Purity: 90%
Packaging: 5g
Price: $30
Updated: 2023/06/20

TCI Chemical

Product number: D2385
Product name: 2',4'-Dichloro-5'-fluoroacetophenone
Packaging: 25g
Price: $32
Updated: 2025/07/31

TRC

Product number: D438723
Product name: 2'',4''-Dichloro-5''-fluoroacetophenone
Packaging: 2.5g
Price: $75
Updated: 2021/12/16

TRC

Product number: D438723
Product name: 2'',4''-Dichloro-5''-fluoroacetophenone
Packaging: 250mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: PC2398E
Product name: 2',4'-Dichloro-5'-fluoroacetophenone
Purity: 98%
Packaging: 100g
Price: $54
Updated: 2021/12/16

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2,4-Dichloro-5-fluoroacetophenone Chemical Properties,Usage,Production

Application

2,4-Dichloro-5-fluoroacetophenone is an important chemical raw material used as a pharmaceutical intermediate. It is a major intermediate for the third-generation broad-spectrum and highly effective quinolone antibacterial agents ciprofloxacin and enrofloxacin.

Chemical Properties

white to light yellow cryst. low melting solid

Synthesis

1435-48-9

75-36-5

704-10-9

In a 1000 mL four-necked flask, 15 g (0.091 mol) of 2,4-dichlorofluorobenzene was added and cooled to 20°C. The solution was then purified with aluminum chloride. Subsequently, 200.2 g (1.5 mol) of aluminum chloride was added, the temperature was maintained between 20-30°C, and 78.5 g (1.0 mol) of acetyl chloride was slowly added dropwise, with the dropwise process being controlled to be completed in 2 to 3 hours. The reaction mixture was gradually heated to 40°C and maintained for 30 minutes, then slowly warmed to 70°C and maintained for 1~2 hours. Then, the heating was continued slowly to 110°C and the reaction was carried out at 110±2°C for 3~4 hours. After the reaction was completed, it was cooled to room temperature, 500 g of 5% hydrochloric acid solution was added and hydrolyzed at 80~90°C for 2~3 hours. After the hydrolysis product was washed to neutral, the organic phase was separated and purified by secondary distillation and recrystallization to obtain 168 g of 2',4'-dichloro-5'-fluoroacetophenone with a purity of 99.8% and a yield of 89.3%.

References

[1] Patent: CN102249881, 2016, B. Location in patent: Paragraph 0020; 0082-0083
[2] Tetrahedron Letters, 2009, vol. 50, # 21, p. 2525 - 2528
[3] Patent: WO2010/58421, 2010, A2. Location in patent: Page/Page column 20-21
[4] Patent: US6967205, 2005, B1. Location in patent: Page/Page column 25-26

2,4-Dichloro-5-fluoroacetophenone Preparation Products And Raw materials

Raw materials

Acetyl chloride Fluorobenzene 1,3-Dichloro-4-fluorobenzene Aluminum chloride

Preparation Products

Ciprofloxacin hydrochloride TEMAFLOXACIN Sarafloxacin Ciprofloxacin

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2,4-Dichloro-5-fluoroacetophenone Suppliers

Americas 1 Belgium 2 Canada 4 China 272 Europe 4 France 2 Germany 2 India 39 Italy 1 Japan 5 Jordan 1 Slovakia 1 South Africa 1 South Korea 1 Switzerland 2 The Netherlands 2 Ukraine 2 United Kingdom 22 United States 39 Global 403

Taizhou Jun Rui Import and Export Co., Ltd.

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Energy Chemical

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View Lastest Price from 2,4-Dichloro-5-fluoroacetophenone manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2,4-Dichloro-5-fluoroacetophenone 704-10-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-22

Shaanxi Dideu New Materials Co. Ltd

Product: 2,4-Dichloro-5-fluoroacetophenone 704-10-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-27

Henan Fengda Chemical Co., Ltd

Product: 1-(2,4-Dichloro-5-fluorophenyl)ethanone 704-10-9
Price: US $9.00-0.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-23

704-10-9, 2,4-Dichloro-5-fluoroacetophenoneRelated Search:

Acetophenone 3-Nitroacetophenone Trifluoroacetophenone 3'-Fluoroacetophenone 4-Nitroacetophenone 4'-(Trifluoromethyl)acetophenone 2',4'-Difluoroacetophenone Dichloroacetonitrile PIPERACETAZINE (250 MG) 4-Fluoroacetophenone 4'-Hydroxyacetophenone 3'-(Trifluoromethyl)acetophenone 4'-Methoxyacetophenone 2',4'-Dichloroacetophenone METHYL 3-(CYCLOPROPYLAMINO)-2-(2,4-DICHLORO-5-FLUOROBENZOYL)ACRYLATE 2,6-Dichloro-3-fluoroacetophenone 3',5'-DICHLORO-2'-FLUOROACETOPHENONE,3,5-DICHLORO-2-FLUOROACETOPHENONE (Z)-3-CYCLOPROPYLAMINO-2-(2,4-DICHLORO-5-FLUORO-BENZOYL)-ACRYLIC ACID ETHYL ESTER

2,4-DICHLORO-5-FLUOROACETOPHENONE

1-(2,4-DICHLORO-5-FLUOROPHENYL)ETHAN-1-ONE

1-(2,4-DICHLORO-5-FLUORO-PHENYL)-ETHANONE

2',4'-Dichloro-5'-Fluoroacetophenone 2,4-Dichloro-5-Fluoroacetophenone

2',4'-DICHLORO-5'-FLUOROACETOPHENONE, 90

2',4'-Dichloro-5'-fluoroacetophenone 98%

2',4'-Dichloro-5'-fluoroacetophenone98%

2,4- Dichloro -5-fluorohypnone

2,4- twochlorine-5- fluoroAcetophenone

Ethanone,1-(2,4-dichloro-5-fluorophenyl)-

2',4'-Dichloro-5'-fluoroacetophenone 98%, 4'-Dichloro-5'-fluoroacetophenone 98%

DCFA ( 2,4-Dichloro-5-Fluoro-Acetophenone)

2',4'-Dichloro-5'-Fluoroacet

2,4-Dichloro-5-fluor

2,4-dichloro-5-fluoroben

2, 4 - dichloro - 5 - fluorine acetophenone

2',4'-DICHLORO-5'-FLUOROACETOPHENONE

Ciprofloxacin Impurity 18

2,4-Dichloro-5-flouroacetophenone

704-10-9 2,4-Dichloro-5-fluoroacetophenone

2',4'- dichloro -5'- fluoroacetophenone

2,4-Dichloro-5-fluorobenzophenone

2′,4′-Dichloro-5′-fluoroacetophenone, CAS 704-10-9

704-10-9

C8H5C12FO

C7 to C8

Carbonyl Compounds

Building Blocks

Ketones

Organic Building Blocks

Ciprofloxacin intermediate

C7 to C8

Carbonyl Compounds

Ketones

ketone

FINE Chemical & INTERMEDIATES

Aromatic Acetophenones & Derivatives (substituted)

K00001