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Ciprofloxacin

Product Name
Ciprofloxacin
CAS No.
85721-33-1
Chemical Name
Ciprofloxacin
Synonyms
CPFX;Cipro;Baycip;Cipmbay;ciloxan;ciproiv;Ciprine;CiprofL;Ciprinol;Ciproxin
CBNumber
CB7217221
Molecular Formula
C17H18FN3O3
Formula Weight
331.34
MOL File
85721-33-1.mol
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Ciprofloxacin Property

Melting point:
255-257°C
Boiling point:
581.8±50.0 °C(Predicted)
Density 
1.461±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Soluble in 0.1N HCl at 25mg/ml. Poorly soluble in DMSO
form 
powder
pka
pKa 4.04 (Uncertain)
Water Solubility 
86mg/L(25 ºC)
Merck 
14,2314
BRN 
3568352
CAS DataBase Reference
85721-33-1(CAS DataBase Reference)
EPA Substance Registry System
Ciprofloxacin (85721-33-1)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
2
RTECS 
VB1993800
HS Code 
29339900
Hazardous Substances Data
85721-33-1(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
17850
Product name
Ciprofloxacin
Purity
≥98.0% (HPLC)
Packaging
5g-f
Price
$69.6
Updated
2021/12/16
Sigma-Aldrich
Product number
17850
Product name
Ciprofloxacin
Purity
≥98% (HPLC)
Packaging
5 g
Price
$71.8
Updated
2021/12/16
Sigma-Aldrich
Product number
17850
Product name
Ciprofloxacin
Purity
≥98.0% (HPLC)
Packaging
25g-f
Price
$158
Updated
2021/12/16
Sigma-Aldrich
Product number
17850
Product name
Ciprofloxacin
Purity
≥98% (HPLC)
Packaging
25 g
Price
$163
Updated
2021/12/16
Sigma-Aldrich
Product number
Y0000198
Product name
Ciprofloxacin
Purity
European Pharmacopoeia (EP) Reference Standard
Price
$190
Updated
2021/12/16
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Ciprofloxacin Chemical Properties,Usage,Production

Description

Ciprofloxacin is a quinolone antibacterial related to recently marketed norfloxacin (10), ofloxacin (2), pefloxacin (2) and enoxacin. It has a broad spectrum of activity against gram-positive and gram-negative bacteria, and is useful in the treatment of urinary and upper respiratory tract infections.

Chemical Properties

White Powder

Originator

Bayer (W. Germany)

Uses

Ciprofloxacin is used in the treatment of infections from a wide range of aerobic gram-positive and aerobic gramnegative microorganisms. It has been shown to be effective against inhalational anthrax and reduce the incidence or progression of disease following exposure to aerosolized Bacillus anthracis. It is also used in select respiratory infections, urinary tract infections, typhoid fever, some sexually transmitted diseases, and septicemia. Infectious diarrhea may be caused by organisms found in food or water and transferred by person-to-person contact. This may have a devastating effect, globally, especially in immunocompromised individuals. Ciprofloxacin is effective against those organisms that may contribute to infectious diarrhea, such as Escherichia coli (enterotoxigenic strains), Campylobacter jejuni, and select strains of Shigella; and is utilized when antibacterial therapy is medically indicated. Ciprofloxacin has also been utilized as a secondary agent in the treatment of tuberculosis.

Uses

Ciprofloxacin, inhibits bacterial DNA gyrase (topoisomerase). Inhibits cell division and causes double-strand breaks in the bacterial chromosome.

Uses

Fluorinated quinolone antibacterial

Definition

ChEBI: A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.

Manufacturing Process

Cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid was synthesized by heating of a mixture of 7-chloro-1-cyclopropyl-6- fluoro-1,4-dihydro-4-oxo-quinolin-3-carboxylic acid and 30.1 g dry piperazine in 100 ml DMSO for 2 hours at 135-140°C. DMSO was evaporated in high vacuum. The residue was heated with 100 ml of water, and was dried over CaCl2 in vacuum. Cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3- quinolinecarboxylic acid obtained has a temperature of decomposition 255- 257°C.

brand name

Cipro (Bayer);CIPROBAY.

Therapeutic Function

Antibiotic

Antimicrobial activity

It exhibits potent activity against most Enterobacteriaceae, as well as against Acinetobacter spp. (MIC 0.25–1 mg/L), fastidious Gram-negative bacilli such as Mor. catarrhalis (MIC 0.06–0.25 mg/L) and Campylobacter jejuni(MIC 0.12 mg/L). In common with other quinolones, it is active against Bacillus anthracis. Ciprofloxacin is the most active quinolone against Ps. aeruginosa and exhibits good activity in vitro against other non-fermenting Gram-negative bacilli. In-vitro activity against Staph. aureus coagulase-negative staphylococci, Str. pyogenes, Str. pneumoniae and Enterococcus spp. (MIC c. 0.5–2 mg/L) is moderate. Most methicillin-resistant strains of staphylococci are resistant. It has poor activity against anaerobes, but is active against M. tuberculosis, Mycoplasma spp. and intracellular pathogens such as Chlamydia, Chlamydophila and Legionella.

Pharmaceutical Applications

A 6-fluoro, 7-piperazinyl quinolone formulated as the hydrochloride for oral administration and as the lactate for intravenous use.

Pharmacokinetics

Oral absorption: 50–80%
Cmax 500 mg oral: 1.5–2 mg/L after 1–2 h
200 mg intravenous (15-min infusion): 3.5 mg/L end infusion
Plasma half-life: 3–4 h
Volume ofdistribution: 3–4 L/kg
Plasma protein binding: 20–40%
Absorption
After escalating oral doses, mean peak plasma levels increase proportionately with dose. However, accumulation occurs after repeated doses of 500 mg orally or 200 mg intravenously every 12 h: the apparent elimination half-life has been reported to rise to about 6 h after a regimen of 250 mg every 12 h for 6 days. Absorption is delayed, but seems unaffected by food and, in common with other quinolones, is reduced by certain antacids. Co-administration of sucralfate reduces the peak plasma concentrations to undetectable levels in many subjects (mean value from 2 to 0.2 mg/L) and the AUC is reduced to 12% of the value obtained when ciprofloxacin is administered alone. Ferrous sulfate and multivitamin preparations containing zinc significantly reduce absorption, which is also impaired in patients receiving cytotoxic chemotherapy for hematological malignancies. Calculated total bioavailability is 60–70%.
Distribution
It is widely distributed in body fluids, concentrations in most tissues and in phagocytic cells approximating those in plasma. Concentrations in the CSF, even in the presence of meningitis, are about half the simultaneous plasma levels.
Metabolism and excretion
It is partly metabolized to four metabolites, all but one of which (desethylciprofloxacin) display antibacterial activity. About 95% of a dose can be recovered from feces and urine. Around 40% of an oral and 75% of an intravenous dose appear in the urine over 24 h. Elimination is by both glomerular filtration and tubular secretion (60–70%) and is reduced by concurrently administered probenecid and by renal insufficiency. It is poorly removed by hemodialysis. Part of the administered drug is eliminated in the bile. An enterohepatic cycle results in prolongation of the half-life. The four metabolites are eliminated in the urine and feces at low concentration in comparison to the parent compound.

Side effects

Untoward reactions are uncommon, those encountered being typical of the group. Reactions severe enough to require withdrawal of treatment have occurred in <2% of patients. The most common reactions, gastrointestinal tract disturbances, have been seen in 5% of patients and rashes in about 1%. CNS disturbances typical of quinolones have been reported in 1–2% of patients. Tendinitis and tendon rupture (especially of the Achilles tendon) may occur in a small number of patients and ciprofloxacin should be avoided in patients at risk for these conditions. Potentiation of the action of theophylline and other drugs metabolized by microsomal enzymes may occur. Crystalluria and transient arthralgia have been reported.
In volunteers, dosages of up to 750 mg produced no change in the numbers of fecal streptococci and anaerobes, but did produce a 2.5 × log10 decline in the numbers of enterobacteria, which lasted 1 week. There was no change in the susceptibility of the affected organisms and no overgrowth by resistant strains. As with other quinolones, ciprofloxacin is not recommended for use in children or in pregnant or lactating women.
The drug should be avoided in suspected or confirmed infections caused by Str. pneumoniae. It is inferior to conventional agents and some other fluoroquinolones in the treatment of genital tract infections caused by C. trachomatis.
Ciprofloxacin has also been shown to be effective in the treatment of patients with malignant otitis externa, catscratch disease, prevention of infection in patients undergoing biliary tract surgery, and treatment of biliary tract infections. A topical preparation for use in the treatment of ocular infections is available, but is neither more effective nor safer than established topical agents; it may be indicated for superficial eye infections caused by pathogens resistant to conventional drugs or in patients unable to tolerate standard therapeutic agents.

Chemical Synthesis

Ciprofloxacin, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolincarboxylic acid (33.2.19), is synthesized in a completely analogous scheme, except that instead of using ethyl iodide in the alkylation stage, cyclopropyl bromide is used.

Veterinary Drugs and Treatments

Because of its similar spectrum of activity, ciprofloxacin could be used as an alternative to enrofloxacin when a larger oral dosage form or intravenous product is desired. But the two compounds cannot be considered equivalent because of pharmacokinetic differences (see below).

Environmental Fate

The antimicrobial action of the drug is due to inhibition of the enzymes required for bacterial DNA function. Topoisomerase II (DNA gyrase) and topoisomerase IV are necessary for bacterial DNA replication, transcription, strand repair, and recombination. Thus, ciprofloxacin cytotoxicity may be caused by the loss of mtDNA encoded functions.

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Ciprofloxacin Suppliers

Zhejiang Guobang Pharmaceutical Co., Ltd.
Tel
--
Fax
--
Email
gb@gbpharm.com
Country
China
ProdList
155
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J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
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76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
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62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15877
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TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
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China
ProdList
2346
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TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
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BeiJing Hwrk Chemicals Limted
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0757-86329057-
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0757-86311057
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sales.gd@hwrkchemical.com
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China
ProdList
17295
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Energy Chemical
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021-58432009-
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021-58436166
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sales8178@energy-chemical.com
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China
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43431
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Beijing Ouhe Technology Co., Ltd
Tel
010-82967028-
Fax
+86-10-82967029
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2355560935@qq.com
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China
ProdList
12270
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Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
9917
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View Lastest Price from Ciprofloxacin manufacturers

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Ciprofloxacin base 85721-33-1
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-11-09
Hebei Yime New Material Technology Co., Ltd.
Product
Ciprofloxacin/ciprofloxacine/ Base 85721-33-1
Price
US $50.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1000kg
Release date
2021-11-17
HEBEI YINGONG NEW MATERIAL TECHNOLOGY CO.,LTD
Product
Ciprofloxacin 85721-33-1
Price
US $200.00/KG
Min. Order
10g
Purity
99%
Supply Ability
500kg/month
Release date
2021-12-02

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