Grepafloxacin

Product Name: Grepafloxacin
CAS No.: 119914-60-2
Chemical Name: Grepafloxacin
Synonyms: GREPAFLOXACIN;dl-Grepafloxacin;Grepafloxacin USP/EP/BP;Grepafloxacin/OPC-17116/dl-Grepafloxacin;1-Cyclopropyl-6-fluoro-7-(3-methyl-1-piperazinyl)-5-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
CBNumber: CB5136636
Molecular Formula: C19H22FN3O3
Formula Weight: 359.39
MOL File: 119914-60-2.mol

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Grepafloxacin Property

Melting point:: 189-192 ºC
Boiling point:: 610.0±55.0 °C(Predicted)
Density: 1.366
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 6.44±0.50(Predicted)
color: Pale Beige to Pale Yellow
Stability:: Hygroscopic
CAS DataBase Reference: 119914-60-2(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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Grepafloxacin Chemical Properties,Usage,Production

Uses

dl-Grepafloxacin is an antibacterial compound used to treat various respirator infections.

Definition

ChEBI: Grepafloxacin is a member of quinolines, a quinolone antibiotic and a fluoroquinolone antibiotic.

in vivo

Grepafloxacin (OPC-17116; 200 mg/kg; p.o.; Balb/c mice) displays good safety profile in terms of phototoxicity^[2].
Grepafloxacin (25-200 mg/kg; p.o.; 5 days/week for 4 weeks; female C57BL6/J-Lyst bg-J/ mice/beige mice) has modest activities in both intranasal (IN) infection and intravenous (IV) Mycobacterium aviuminfection models^[3].

Animal Model:	Female Balb/c mice (5-6 weeks)^[2]
Dosage:	200 mg/kg
Administration:	Oral administration; once
Result:	Had mild and short-lived erythema and no changed auricular thickness.

Animal Model:	Female C57BL6/J-Lyst bg-J/ mice/beige mice with mycobacterium avium infection^[3]
Dosage:	25, 50, 100, and 200 mg/kg
Administration:	Oral administration; 5 days/week for 4 weeks
Result:	Had bactericidal activity and limited the growth of the bacteria.

IC 50

Quinolone

Grepafloxacin Preparation Products And Raw materials

Raw materials

Preparation Products

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Grepafloxacin Suppliers

China 32 Europe 2 Germany 1 India 3 South Korea 1 United Kingdom 3 United States 8 Global 50

J & K SCIENTIFIC LTD.

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Shanghai Sunway Pharmaceutical Technology Co., Ltd

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Beijing HuaMeiHuLiBiological Chemical

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The future of Shanghai Industrial Co., Ltd.

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Shanghai JONLN Reagent Co., Ltd.

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Pharmacodia (Beijing) Co.,Ltd

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Aikon International Limited

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Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.

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Shenzhen Polymeri Biochemical Technology Co., Ltd.

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View Lastest Price from Grepafloxacin manufacturers

Dideu Industries Group Limited

Product: Grepafloxacin 119914-60-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-19

Career Henan Chemical Co

Product: Grepafloxacin 119914-60-2
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2019-12-25

119914-60-2, GrepafloxacinRelated Search:

Cyclopropyl methyl ketone Tribenuron methyl Chloromethyl isopropyl carbonate Methyl salicylate Moxifloxacin METSULFURON METHYL 1-AdaMantanethylaMine 3-Methyl-2-butanone Ofloxacin Norfloxacin Ciprofloxacin Levofloxacin Gatifloxacin Quinclorac 1-Methylpiperazine Kresoxim-methyl Thiophanate-methyl Methyl

GREPAFLOXACIN

1-Cyclopropyl-6-fluoro-7-(3-methyl-1-piperazinyl)-5-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

dl-Grepafloxacin

Grepafloxacin USP/EP/BP

Grepafloxacin/OPC-17116/dl-Grepafloxacin

119914-60-2