Chloromethyl isopropyl carbonate

Product Name: Chloromethyl isopropyl carbonate
CAS No.: 35180-01-9
Chemical Name: Chloromethyl isopropyl carbonate
Synonyms: CMIC;Chloromethy Isopropyl carbonate;ALSTint-A08;Chloromethyl isoprop;Tenofovir Impurity 56;Tenofovir CMIC Impurity;Tenofovir Impurity 41 CRS;Tenofovir intermediate(CMIC);L-Propylchloromethylcarbonate;Chloromethyl isopropyl carbote
CBNumber: CB0223267
Molecular Formula: C5H9ClO3
Formula Weight: 152.58
MOL File: 35180-01-9.mol

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Chloromethyl isopropyl carbonate Property

Boiling point:: 66 °C(Press: 16 Torr)
Density: 1.14
refractive index: 1.4110-1.4150
Flash point:: 50°
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform (Slightly), DMSO, Ethyl Acetate (Slightly)
form: clear liquid
color: Colorless to Almost colorless
Stability:: Moisture sensitive
Major Application: pharmaceutical (small molecule)
InChI: InChI=1S/C5H9ClO3/c1-4(2)9-5(7)8-3-6/h4H,3H2,1-2H3
InChIKey: JHYNXXBAHWPABC-UHFFFAOYSA-N
SMILES: C(OC(C)C)(=O)OCCl
CAS DataBase Reference: 35180-01-9(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
RIDADR: 2924
WGK Germany: WGK 3
HazardClass: 3/8
PackingGroup: Ⅲ
HS Code: 29189900
Storage Class: 10 - Combustible liquids
Hazard Classifications: Aquatic Chronic 2
Skin Irrit. 2
Skin Sens. 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1115705
Product name: Chloromethyl isopropyl carbonate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 100MG
Price: $1360
Updated: 2025/07/31

TCI Chemical

Product number: C2626
Product name: Chloromethyl Isopropyl Carbonate
Purity: >98.0%(GC)
Packaging: 25g
Price: $54
Updated: 2025/07/31

TCI Chemical

Product number: C2626
Product name: Chloromethyl Isopropyl Carbonate
Purity: >98.0%(GC)
Packaging: 100g
Price: $162
Updated: 2025/07/31

Usbiological

Product number: 268404
Product name: Chloromethyl isopropyl carbonate
Packaging: 5g
Price: $360
Updated: 2021/12/16

TRC

Product number: C369230
Product name: Chloromethyl Isopropyl Carbonate
Packaging: 100g
Price: $470
Updated: 2021/12/16

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Chloromethyl isopropyl carbonate Chemical Properties,Usage,Production

Chemical Properties

Clear Colourless Liquid

Uses

Chloromethyl Isopropyl Carbonate is an antiviral agent and a Tenofovir (T018500) intermediate. Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor used as an anti-HIV agent.

Synthesis

At 0-5°C, a photoinitiator is added, and dimethyl carbonate and chlorine are subjected to light reaction. The reaction is stopped, and the product is distilled and separated to obtain dimethyl monochlorocarbonate. At 70-100°C, a catalyst is added, and dimethyl monochlorocarbonate and isopropanol are added to a distillation tower capable of controlling the reflux ratio. Methanol is distilled and separated under normal pressure while reacting. After the reaction is completed, excess isopropanol is distilled off under reduced pressure, and finally chloromethyl isopropyl carbonate is distilled under reduced pressure.

References

[1] Tetrahedron, 2011, vol. 67, # 29, p. 5319 - 5328
[2] Patent: JP2015/164934, 2015, A. Location in patent: Paragraph 0195
[3] Journal of Medicinal Chemistry, 2009, vol. 52, # 3, p. 771 - 778
[4] Patent: WO2004/92189, 2004, A1. Location in patent: Page 29
[5] Journal of Medicinal Chemistry, 2015, vol. 58, # 23, p. 9133 - 9153

Chloromethyl isopropyl carbonate Preparation Products And Raw materials

Raw materials

Preparation Products

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Chloromethyl isopropyl carbonate Suppliers

Americas 1 Belgium 2 Canada 2 China 374 Europe 1 Germany 1 India 49 Italy 1 Japan 2 United Kingdom 15 United States 32 Global 480

Huangshi Fuertai Pharmaceutical Tech Co., Ltd.

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Saintchem Chemical Co., Ltd.

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Yangzhou Sanyou Synthesis Chemical Co., Ltd

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J & K SCIENTIFIC LTD.

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3B Pharmachem (Wuhan) International Co.,Ltd.

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TCI (Shanghai) Development Co., Ltd.

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ShangHai DEMO Chemical Co.,Ltd

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Ark Pharm, Inc.

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Country: United States
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View Lastest Price from Chloromethyl isopropyl carbonate manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: chloromethyl isopropyl carbonate 35180-01-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-12-22

Dideu Industries Group Limited

Product: Chloromethyl isopropyl carbonate 35180-01-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2025-09-12

Hebei Chuanghai Biotechnology Co., Ltd

Product: Chloromethyl isopropyl carbonate 35180-01-9
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-18

35180-01-9, Chloromethyl isopropyl carbonateRelated Search:

Chloromethyl ethyl carbonate Diethyl (tosyloxy)methylphosphonate Tenofovir Fluorobenzene Sodium metabisulfite Quinolinic acid Chloromethyl chlorosulfate Chloromethyl isobutyrate (S)-Metolachlor N2-ISOBUTYRYL-2'-DEOXYGUANOSINE 2-Hydroxypropyl methacrylate Allyl methacrylate Isopropyl chloroformate Diisopropyl peroxydicarbonate Triphosgene rac-Tenofovir-d7 ChloroMethyl Propyl Carbonate Propylene carbonate

CMIC

CHLOROMETHYL ISOPROPYL CARBONATE

I-PROPYL CHLOROMETHYL CARBONATE

Chloromethyl (1-Methylethyl) Carbonate

Chloromethyl-2-propyl carbonate

L-Propylchloromethylcarbonate

Chloromethyl Isopropyl Carbonate (JMC-1)

Carbonic acid, chloromethyl 1-methylethyl ester

Chloromethy Isopropyl carbonate

Chloromethyl Isopropyl Carbonate (CMIC) ( CAS No. : )

Chloromethyl isopropyl carbonate ,99%

Chloromethyl isoprop

Carbonic Acid ChloroMethyl Isopropyl Ester

[(Isopropyloxycarbonyl)oxy]Methyl Chloride

chloroMethyl isopropyl carbonate (Sanyou)

ChloroMethyl Isopropyl Carbonate, 95+%

Chlorine Methyl isopropyl carbonate

Tenofovir intermediate(CMIC)

Chloromethyl isopropyl carbonate, >=99.5%

carbonic acid chloromethyl ester isopropyl ester

Chloromethyl isopropyl carbonate(CMIC)

Chioromethyl isopropyl carbonate

Chloromethyl isopropyl carbote

Tenofovir Disoproxil Fumarate impurity S

ALSTint-A08

Tenofovir Impurity 56

Chloromethyl Isopropyl Carbonate &gt

Tenofovir CMIC Impurity

TIANFU-CHEM - Chloromethyl isopropyl carbonate

Chloromethyl isopropyl carbonate [Tenofovir Disoproxil Fumarate Impurity

Tenofovir Impurity 41 CRS

Tenofovir disoproxil Impurity 96

chloromethyl propan-2-yl carbonate

Chloromethyl isopropyl carbonate, 98%

Chloromethylisopropylisocarbonate

35180-01-9

5180-1-9

Miscellaneous Reagents

Pharmaceutical Intermediates

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