Diethyl (tosyloxy)methylphosphonate
- Product Name
- Diethyl (tosyloxy)methylphosphonate
- CAS No.
- 31618-90-3
- Chemical Name
- Diethyl (tosyloxy)methylphosphonate
- Synonyms
- DESMP;(DIETHOXYPHOSPHORYL)METHYL 4-METHYLBENZENESULFONATE;DESM;Tenofovir intermediate;oxy)methyL;DESMP (DMESP/TSDEP);Tenofovir Impurity 36;Adefovir Impurity 6 CRS;Ethy16,8-dichlorooctanoate;1,3-dimethyl-36-nitrosourea
- CBNumber
- CB9101524
- Molecular Formula
- C12H19O6PS
- Formula Weight
- 322.31
- MOL File
- 31618-90-3.mol
Diethyl (tosyloxy)methylphosphonate Property
- Boiling point:
- 137°C/0.02mmHg(lit.)
- Density
- 1.255
- refractive index
- 1.4980 to 1.5020
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Chloroform (Sparingly), Dichloromethane, Ethyl Acetate, Methanol (Sparingly)
- form
- Oil
- color
- Clear Colourless to Pale Yellow
- InChI
- InChI=1S/C12H19O6PS/c1-4-16-19(13,17-5-2)10-18-20(14,15)12-8-6-11(3)7-9-12/h6-9H,4-5,10H2,1-3H3
- InChIKey
- UOEFFQWLRUBDME-UHFFFAOYSA-N
- SMILES
- P(COS(C1=CC=C(C)C=C1)(=O)=O)(=O)(OCC)OCC
- CAS DataBase Reference
- 31618-90-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D4968
- Product name
- Diethyl (p-Toluenesulfonyloxymethyl)phosphonate
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $22
- Updated
- 2025/07/31
- Product number
- D445260
- Product name
- Diethyl (p-Toluenesulfonyloxymethyl)phosphonate
- Packaging
- 25g
- Price
- $155
- Updated
- 2021/12/16
- Product number
- FD10108
- Product name
- Diethyl p-tosyloxymethylphosphonate
- Packaging
- 500g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- OPC0000204
- Product name
- DIETHYL(TOSYLOXY)METHYLPHOSPHONATE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $2055.9
- Updated
- 2021/12/16
- Product number
- OPC0000204
- Product name
- DIETHYL(TOSYLOXY)METHYLPHOSPHONATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $704.55
- Updated
- 2021/12/16
Diethyl (tosyloxy)methylphosphonate Chemical Properties,Usage,Production
Chemical Properties
Pale Yellow Oil
Uses
Diethyl (tosyloxy)methylphosphonate is an antiviral agent and a Tenofovir intermediate. Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor used as an anti-HIV agent.
Uses
Diethyl p-Toluenesulfonyloxymethylphosphonate is an antiviral agent and a Tenofovir (T018500) intermediate. Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor used as an anti-HIV agent.
Synthesis
3084-40-0
98-59-9
31618-90-3
The general procedure for the synthesis of diethyl p-toluenesulfonyl oxymethylphosphonate from diethyl hydroxymethylphosphonate and p-toluenesulfonyl chloride was as follows: first, diethyl hydroxymethylphosphonate (51 kg, 1107 mol) and diethyl phosphite (22 kg, 159.3 mol) were added to a glass autoclave, followed by the addition of anhydrous ethanol to promote mixing. After stirring until the mixture was homogeneous, paraformaldehyde (5.5 kg, 61.06 mol) and triethylamine (1.4 kg, 13.84 mol) were added to the kettle. The mixture was heated to 40°C for 0.5-1 hr for the reaction, and then warmed to 50-65°C to continue the reaction for 5 hr. Upon completion of the reaction, the mixture was cooled to 30-40°C, the solids were filtered by adding 0.3 kg of diatomaceous earth and washed with 2 kg of anhydrous ethanol. The filtrate and washings were combined and concentrated under reduced pressure at 55°C to remove ethanol. After concentration, toluene (18 kg, 195.35 mol) was added and concentration was continued until the ethanol was completely evaporated. After cooling the mixture to 30°C, it was further cooled to below -10°C and triethylamine (15.2 kg, 150.21 mol) was slowly added dropwise and p-toluenesulfonyl chloride (24.5 kg, 128.51 mol) was added in batches. The temperature was controlled at -3 to -10°C during the dropwise addition and stirring was continued for 1 hour after completion of the dropwise addition. The mixture was then heated to 19-25°C and the reaction was held for 2.5-3.5 hours. Upon completion of the reaction, 18 kg of water was added for washing and 5 kg of anhydrous sodium sulfate was added for drying for 6 hours. After filtration, the filtrate was concentrated under reduced pressure at 65°C to remove the solvent. The residue was a thickened form of diethyl p-toluenesulfonyl oxymethylphosphonate. Further distillation under reduced pressure at elevated temperature (152°C, 2-3 mmHg) afforded 30.14 kg of bouquets of diethyl p-toluenesulfonyl oxymethylphosphonate with ≥99% purity in 137% yield.
References
[1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994, # 11, p. 1477 - 1482
[2] Synlett, 2016, vol. 27, # 9, p. 1423 - 1427
[3] Patent: CN106699814, 2017, A. Location in patent: Paragraph 0017-0019
[4] Collection of Czechoslovak Chemical Communications, 1982, vol. 47, # 12, p. 3447 - 3463
[5] Patent: CN105541910, 2016, A. Location in patent: Paragraph 0031; 0032; 0034
Diethyl (tosyloxy)methylphosphonate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Diethyl (tosyloxy)methylphosphonate manufacturers
- Product
- Diethyl (tosyloxy)methylphosphonate/DESMP 31618-90-3
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 10000kg
- Release date
- 2021-11-05
- Product
- Diethyl (tosyloxy)methylphosphonate 31618-90-3
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-19
- Product
- Diethyl (tosyloxy) Methylphosphonate 31618-90-3
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-22