Role and purpose Uses Production methods
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p-Toluenesulfonamide

Role and purpose Uses Production methods
Product Name
p-Toluenesulfonamide
CAS No.
70-55-3
Chemical Name
p-Toluenesulfonamide
Synonyms
PTSA;PASAM;Tosylamide;Tosylamine;Uniplex 173;p-Tosylamide;p-Toluenesulfo;Tolylsulfonamide;p-Toluenesulfomide;p-Toluolsulfonamid
CBNumber
CB7330843
Molecular Formula
C7H9NO2S
Formula Weight
171.22
MOL File
70-55-3.mol
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p-Toluenesulfonamide Property

Melting point:
134-137 °C (lit.)
Boiling point:
221 °C (10 mmHg)
Density 
1.2495 (rough estimate)
vapor density 
5.9 (vs air)
refractive index 
1.6100 (estimate)
Flash point:
202 °C
storage temp. 
Store below +30°C.
solubility 
DMSO: soluble
pka
10.20±0.10(Predicted)
form 
Crystalline Powder
color 
White
Odor
Odorless
Water Solubility 
0.32 g/100 mL (25 º C)
BRN 
472689
CAS DataBase Reference
70-55-3(CAS DataBase Reference)
NIST Chemistry Reference
4-Methylbenzenesulfonamide(70-55-3)
EPA Substance Registry System
p-Toluenesulfonamide (70-55-3)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36-20/21/22
Safety Statements 
26-36
WGK Germany 
1
RTECS 
XT5075000
TSCA 
Yes
PackingGroup 
III
HS Code 
29350090
Hazardous Substances Data
70-55-3(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.08230
Product name
4-Toluenesulfonamide
Purity
for synthesis
Packaging
100 g
Price
$19.7
Updated
2021/12/16
Sigma-Aldrich
Product number
105902
Product name
p-Toluenesulfonamide
Purity
reagent grade, 98%
Packaging
250g
Price
$25.1
Updated
2021/12/16
Sigma-Aldrich
Product number
105902
Product name
p-Toluenesulfonamide
Purity
reagent grade, 98%
Packaging
1kg
Price
$71.4
Updated
2021/12/16
Sigma-Aldrich
Product number
8.08230
Product name
4-Toluenesulfonamide
Purity
for synthesis
Packaging
1 kg
Price
$67.89
Updated
2021/12/16
Sigma-Aldrich
Product number
8.08230
Product name
4-Toluenesulfonamide
Purity
for synthesis
Packaging
25 kg
Price
$435.67
Updated
2021/12/16
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p-Toluenesulfonamide Chemical Properties,Usage,Production

Role and purpose

P-toluene sulfonamide is a kind of excellent solid plasticizer used for thermoset plastic. It is suitable for being applied to phenolic resin, melamine resin, urea-formaldehyde resins and polyamide resins. Combination with a small amount can improve workability and make the solidification be uniform, and thus endowing the products with a good gloss. However, P-toluene sulfonamide has no softening effect as the liquid plasticizer, and is incompatible with polyvinyl chloride and vinyl chloride copolymer and is partially compatible with cellulose acetate, cellulose acetate butyrate and cellulose nitrate.
p-Toluene sulfonamide has a low toxicity. It has been approved by the US Food and Drug Administration for being applied into adhesives as food packaging materials.
p-Toluene sulfonamide is briefly called TSH and is commonly used for nickel plating. It can improve the coating structure by the adsorption on the electrode so that it has some degree of surface glossing effect; it is generally not strictly limited for the added amount of brighteners lax; moreover it also has very light effects on the coating characteristics. However, it can only give semi-bright coatings, and the surface gloss is related to the polishing quality of the matrix before plating.
Currently, the brightener agents of nickel plating used is mostly some kinds of organic compounds. And the used amount of these organic compound, although are very little, but with a significant effect. In addition to brightening the coating, it can also largely determine the mechanical properties and chemical properties of the coating. But it must be realized that, since the bright nickel plating solution has been added to the organic brightener, it naturally makes the nickel plating layer contain a relative big amount of organic sulfur and other impurities, thus inevitably enlarging the internal stress, so its mechanical properties is a bitter lower than the conventional nickel-plate, and is prone to crack layer when the plating gets stress; its antirust ability is also worse than the dark nickel. Thus, a single layer of bright nickel is unable to improve the corrosion resistance and mechanical properties of the nickel layer; it must need to form a bi-layer and multilayer nickel or chromium to form a multilayer combination of decorative protective coatings.
When toluene sulfonamide is heated to 105 °C, it will be decomposed and there will be nitrogen released (gas evolution 130 mL/g); p-toluene sulfonamide foaming agents can give a fine foaming with small product shrinkage. It also has a high tear strength and good stability. Thereby, it has a wide range of applications.
The above information is edited by the chemicalbook of Dai xiongfeng.

Uses

1. It is used in the manufacture of dyes, synthetic resins, paints, disinfectants and wood processing brightener.
2. It is used for the manufacture of plasticizers, disinfectants; it can also be used for the production of synthetic resins, paints, and fluorescent dyes.
3. It can be used as primary brightener in the bright nickel plating. It is sued for bright nickel plating for multilayer to obtain uniform bright coating. It has a commonly used amount of 0.2~0.3 g/L.
4. It can be used as plasticizers, also used for synthesis of organics, resins and saccharin.

Production methods

It is obtained by the reaction between toluenesulfonyl chloride and ammonia.
First, add part of HN3 water into the reaction pot, stirring for adding p-toluenesulfonyl chloride with the temperature rising naturally to above 50 °C; after the temperature has dropped, add the remaining ammonia and have reaction for 0.5 h at 85~90 °C. Stop the reaction when the pH reaches 8 to 9. Cool to 20 °C, filter, and wash the filter cake with water to obtain the crude. Then further go through bleaching via activated carbon, alkali dissolution, acid precipitation, rejection filter, drying to get products.

Chemical Properties

White leaflets. Soluble in alcohol; very slightly soluble inwater.Combustible.

Uses

p-Toluenesulfonamide was used to prepare the precursor required for synthesis of ethyl 6-phenyl-1-tosyl-1,2,5,6-tetrahydropyridine-3-carboxylate.

Uses

4-Tolylsulfonamide is a carbonic anhydrase inhibitor used the synthesis of antiglaucoma and anticancer drugs.

Uses

Used in the manufacture of plasticizer, disinfectant, fungicide, fungicides, wood brightener. Also can be used in the production of synthetic resin, the coating, the fluorescent dye, pharmaceutical, etc.

Definition

ChEBI: A sulfonamide that is benzenesulfonamide bearing a methyl group at position 4.

Synthesis Reference(s)

The Journal of Organic Chemistry, 47, p. 4327, 1982 DOI: 10.1021/jo00143a031
Synthetic Communications, 20, p. 293, 1990 DOI: 10.1080/00397919008052297
Synthesis, p. 1031, 1986 DOI: 10.1055/s-1986-31862

General Description

p-Toluenesulfonamide undergoes FeCl3-catalyzed direct substitution reaction with benzylic and allylic alcohols.It is employed as nucleophile in tetrabutylammonium fluoride (TBAF) catalyzed vinyl aziridine opening reaction.

Purification Methods

Crystallise the amide from hot water, then from EtOH or Et2O/pet ether. [Beilstein 11 H 104, 11 IV 376.]

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p-Toluenesulfonamide Suppliers

Shouguang Nuomeng Chemical Co Ltd.
Tel
536-5399456-
Fax
0536-5399456
Email
sales@nuomengchem.com
Country
China
ProdList
44
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58
Jiaxing Trustworthy Import And Export Co., Ltd.
Tel
+86 (573) 8203-0555
Email
jessica@chinatrustworthy.com
Country
China
ProdList
38
Advantage
56
Credit-Chem Co., Ltd.
Tel
400-821-5857 021-64326257
Fax
021-64393586 QQ;2798200800
Email
credit-chem@foxmail.com
Country
China
ProdList
5229
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58
Heze Kingvolt Chemical Co., Ltd
Tel
+86-15157335533 13505737768
Fax
+86-0573-82118912
Email
richard@kingvoltchem.com
Country
China
ProdList
23
Advantage
55
AbaChemScene
Tel
732-484-9848
Fax
888-484-5008
Email
sales@chemscene.com
Country
United States
ProdList
3989
Advantage
60
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.
Tel
133-96369453- ;
Fax
0536-2101172
Email
sdfantai@163.com;sdfantai@163.com
Country
China
ProdList
801
Advantage
58
Wuhan Rongcan Biotechnology Co., Ltd
Fax
183-27024450
Email
2130026275@qq.com
Country
China
ProdList
2056
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
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76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
+86-021-61259100
Fax
86-21-61259102
Email
int02@meryer.com
Country
China
ProdList
40264
Advantage
62
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
84
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View Lastest Price from p-Toluenesulfonamide manufacturers

Shanxi Naipu Import and Export Co.,Ltd
Product
p-Toluenesulfonamide 70-55-3
Price
US $100.00/ASSAYS
Min. Order
1ASSAYS
Purity
99%
Supply Ability
5000kg/month
Release date
2021-09-24
Zhuozhou Wenxi import and Export Co., Ltd
Product
p-Toluenesulfonamide 70-55-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
p-Toluenesulfonamide 70-55-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

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