Toxicity
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Triphosgene

Toxicity
Product Name
Triphosgene
CAS No.
32315-10-9
Chemical Name
Triphosgene
Synonyms
Triphosg;TRIPHOSGEN;TRIPHOSGENE;triphosqene;Triphosgene98+%;Triphosgene,99%;Triphosgene, BTC;Ritalin Impurity 13;Triphosgene, 99% 5GR;Triphosgene, 98.0%(T)
CBNumber
CB2420273
Molecular Formula
C3Cl6O3
Formula Weight
296.73
MOL File
32315-10-9.mol
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Triphosgene Property

Melting point:
79-83 °C (lit.)
Boiling point:
203-206 °C (lit.)
Density 
1.78
vapor pressure 
16 hPa (90 °C)
Flash point:
203-206°C
storage temp. 
2-8°C
form 
Crystalline Powder, Crystals and/or Chunks
color 
White to off-white
Water Solubility 
practically insoluble
Sensitive 
Moisture Sensitive
BRN 
1787583
InChIKey
UCPYLLCMEDAXFR-UHFFFAOYSA-N
CAS DataBase Reference
32315-10-9(CAS DataBase Reference)
EPA Substance Registry System
Methanol, trichloro-, carbonate (2:1) (32315-10-9)
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Safety

Hazard Codes 
T+,Xn,T
Risk Statements 
26-34-29-36/37/38-20/21/22-23/24/25
Safety Statements 
36/37/39-45-9-26-36-7/9
RIDADR 
UN 2928 6.1/PG 2
WGK Germany 
2
10-19-21
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29209010
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

H330Fatal if inhaled

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P310Immediately call a POISON CENTER or doctor/physician.

P320Specific treatment is urgent (see … on this label).

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.14283
Product name
Bis(trichloromethyl) carbonate
Purity
for synthesis
Packaging
25 g
Price
$113.77
Updated
2021/12/16
Sigma-Aldrich
Product number
15217
Product name
Bis(trichloromethyl) carbonate
Purity
purum, ≥99.0% (AT)
Packaging
10g
Price
$90.4
Updated
2021/12/16
Sigma-Aldrich
Product number
8.14283
Product name
Bis(trichloromethyl) carbonate
Purity
for synthesis
Packaging
100 g
Price
$171.12
Updated
2021/12/16
Sigma-Aldrich
Product number
8.14283
Product name
Bis(trichloromethyl) carbonate
Purity
for synthesis
Packaging
1 kg
Price
$176.67
Updated
2021/12/16
Sigma-Aldrich
Product number
15217
Product name
Bis(trichloromethyl) carbonate
Purity
purum, ≥99.0% (AT)
Packaging
50g
Price
$295
Updated
2021/12/16
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Triphosgene Chemical Properties,Usage,Production

Toxicity

As a common production raw material for chemical enterprises, Sanguang gas is not listed in the list of hazardous chemicals, and its risk is not familiar and understood by many users, which often leads to decomposition and poisoning accidents. Therefore, it is of great practical significance to study the hazards and safety measures in the use of Triphosgene. Based on the characteristic identification of triphosgene, the hazards in the process of dissolution and reaction are identified and analyzed, and the corresponding safety measures in the use of Triphosgene are put forward according to the results of hazard identification and analysis. Triphosgene has gradually become the raw material for acyl chlorination in many enterprises because it is a non hazardous chemical, relatively stable material properties, easy transportation and easy treatment of tail gas. However, if the safety measures are not appropriate during the transportation, storage and use of triphosgene, it is very easy to cause poisoning accidents.

Description

Triphosgene is also known as solid phosgene. Its chemical name is bis (Trichloromethyl) carbonate, and its English name is bisgriehloromethyl) carbonate or triphosgene, abbreviated as BTC. Triphosgene is a white crystal, similar to the smell of phosgene. It is mainly used to synthesize chloroformate, isocyanate, polycarbonate and acyl chloride. It is widely used as an intermediate in plastics, medicine, herbicides and pesticides.

Chemical Properties

White solid

Uses

An efficient carbonylating agent for liquid and solid-phase aza-peptide synthesis.

Uses

Triphosgene is used as a carbonylating agent for aza-peptide synthesis. It reacts with several alfa-amino acids to give the corresponding N-carboxyanhydrides. It is involved in the preparation of the esterification coupling reagent, di-2-thienyl carbonate from 2(5H)-thiophenone. Further, it is used as a reagent in organic synthesis and converts an amino group into isocyanate. In addition to this, it is employed in the preparation of 2-chloronicotinaldehydes through cyclization of the corresponding enamides. It is considered as a useful substitute for phosgene.

Purification Methods

It is a good solid substitute for phosgene (using a third mol per mol). Crystallise it from pet ether (b 60-80o), wash it with anhydrous cold Et2O, de-gas it at 200mm then dry at 0.1mm (over H2SO4). It has IR: max 900 and 1900 cm-1 . It is a lachrymator, is TOXIC and should be handled with gloves and in an efficient fume hood. [Hales et al. J Chem Soc 620 1957, Eckert & Forster Angew Chem, Int Ed Engl 26 894 1987, Aldrichimica Acta 21 47 1988, Beilstein 3 H 17, 3 I 8, 3 II 16, 3 III 36, 3 IV 33.]

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Triphosgene Suppliers

Ningbo biermann pharmaceutical technology co., LTD
Tel
0571-82572971
Email
bichem.sales01@bichem.cn
Country
China
ProdList
40
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
+86-021-61259100
Fax
86-21-61259102
Email
int02@meryer.com
Country
China
ProdList
40264
Advantage
62
Nanjing Xiezun Chemical Co., Ltd.
Tel
025-85620080
Fax
025-85620080
Email
1919348357@qq.com;
Country
China
ProdList
25
Advantage
60
Yancheng Green Chemicals Co.,Ltd.
Tel
Email
marketing@royal-chem.com
Country
China
ProdList
60
Advantage
58
Hefei Qianhang Pharmaceutical Technology Co., Ltd.
Tel
Email
1356223173@qq.com
Country
China
ProdList
54
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2213
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Sichuan Ruibo Technology Co., Ltd
Tel
+86-817-5586080
Fax
+86-817-5527378
Email
sales@scrbkj.com
Country
China
ProdList
42
Advantage
69
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2346
Advantage
56
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View Lastest Price from Triphosgene manufacturers

Anhui Rencheng Technology Co., Ltd
Product
Triphosgene 32315-10-9
Price
US $1.00-499.00/KG
Min. Order
0.5KG
Purity
>99%
Supply Ability
20tons
Release date
2020-12-31
Wuhan Mulei New Material Technology Co. Ltd
Product
Triphosgene 32315-10-9
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99.9%
Supply Ability
100000kg per month
Release date
2021-04-02
Shanxi Naipu Import and Export Co.,Ltd
Product
Bis(trichloromethyl)carbonate 32315-10-9
Price
US $100.00/KG
Min. Order
1KG
Purity
99
Supply Ability
5000
Release date
2021-09-02

32315-10-9, TriphosgeneRelated Search:


  • TRIPHOSGENE
  • BIS(TRICHLOROMETHYL) CARBONATE
  • CARBONIC ACID BISTRICHLOR METHYL ESTER
  • TriphosgeneForSynthesis
  • Triphosgene98+%
  • Triphosgene, 98% [Bis-(trichloromethyl)-carbonat]
  • Methanol, trichloro-, carbonate (2:1)
  • TRICHLOROMETHANOLCARBONATE
  • TRIPHOSGENE (BIS-(TRICHLOROMETHYL)CARBONATE)
  • TRIPHOSGEN
  • Bis(trichloroMethyl) carbonate puruM, >=99.0% (AT)
  • Triphosgene reagent grade, 98%
  • Three chloroMethyl carbonate
  • Triphosgene, 98.0%(T)
  • tri-Phosgene, Triphosgene
  • Carbonic acid bis(trichloromethyl)
  • Carbonic acid bis(trichloromethyl) ester
  • Ritalin Impurity 13
  • Bis(trichlormethyl)carbonat
  • Trichloromethoxyformic acid trichloromethyl ester
  • Triphosgene,99%
  • Triphosgene (Technical grade)
  • BIS(TRICHLOROMETHYL) CARBONATE FOR SYNTH
  • Triphosgene, BTC
  • Bis(trichloromethyl)carbonat
  • triphosqene
  • Triphosgene, 99% 10GR
  • Triphosgene, 99% 5GR
  • Triphosg
  • Methanol, 1,1,1-trichloro-, 1,1'-carbonate
  • Triphosgene fandachem
  • 32315-10-9
  • C3O3Cl6
  • Cl3COCOOCCl3
  • CCl3O2CO
  • C3Cl6O3
  • Building Blocks
  • Carbonyl Compounds
  • Carbonates
  • Organic Building Blocks
  • Coupling
  • Phosgene Derivatives
  • Synthetic Reagents
  • Aliphatics
  • Other Reagents