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Phenyl chloroformate

Product Name
Phenyl chloroformate
CAS No.
1885-14-9
Chemical Name
Phenyl chloroformate
Synonyms
Phenyl carbonochloridate;CARBONOCHLORIDIC ACID;chlorocarbonic acid;PHENYL CHLOROCARBONATE;CHLOROFORMIC ACID PHENYL ESTER;carbonochloridic acid phenyl ester;tl398;PHENYL CHLOROFORMAT;Phenyl choroformate;PHENYL CHLOROFORMATE
CBNumber
CB2702258
Molecular Formula
C7H5ClO2
Formula Weight
156.57
MOL File
1885-14-9.mol
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Phenyl chloroformate Property

Melting point:
-28 °C
Boiling point:
74-75 °C/13 mmHg (lit.)
Density 
1.248 g/mL at 25 °C (lit.)
vapor density 
1 (vs air)
vapor pressure 
1.22 psi ( 20 °C)
refractive index 
n20/D 1.511(lit.)
Flash point:
168 °F
storage temp. 
2-8°C
solubility 
Miscible with N,N-dimethylformamide.
form 
Liquid
color 
Clear
Water Solubility 
hydrolysis
Sensitive 
Moisture Sensitive
BRN 
606778
CAS DataBase Reference
1885-14-9(CAS DataBase Reference)
NIST Chemistry Reference
Carbonochloridic acid, phenyl ester(1885-14-9)
EPA Substance Registry System
Carbonochloridic acid, phenyl ester (1885-14-9)
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Safety

Hazard Codes 
T+
Risk Statements 
22-26-34-41-38-29-37
Safety Statements 
26-28-36/37/39-45-28A
RIDADR 
UN 2746 6.1/PG 2
WGK Germany 
3
RTECS 
FG3850000
10-19-21
Autoignition Temperature
540 °C
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29159020
Toxicity
LD50 orally in Rabbit: 1730 mg/kg LD50 dermal Rabbit 4880 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H290May be corrosive to metals

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H330Fatal if inhaled

H335May cause respiratory irritation

Precautionary statements

P234Keep only in original container.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.02353
Product name
Phenyl chloroformate
Purity
for synthesis
Packaging
250ML
Price
$80.7
Updated
2024/03/01
Sigma-Aldrich
Product number
237906
Product name
Phenyl chloroformate
Purity
97%
Packaging
5g
Price
$89.5
Updated
2024/03/01
Sigma-Aldrich
Product number
167525
Product name
Phenyl chloroformate
Purity
99%
Packaging
100g
Price
$82.3
Updated
2024/03/01
TCI Chemical
Product number
C0649
Product name
Phenyl Chloroformate
Purity
>98.0%(GC)(T)
Packaging
25mL
Price
$20
Updated
2024/03/01
TCI Chemical
Product number
C0649
Product name
Phenyl Chloroformate
Purity
>98.0%(GC)(T)
Packaging
100mL
Price
$34
Updated
2024/03/01
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Phenyl chloroformate Chemical Properties,Usage,Production

Chemical Properties

clear oily liquid. Corrosive. Insoluble in water, soluble in ethanol, ether, easily soluble in petroleum ether.

Uses

Phenyl chloroformate is used in the synthesis of poly(2-(phenoxycarbonyloxy)ethyl methacrylate) and phenyl-(4-vinylphenyl) carbonate. It acts as a precursor of phenyl mixed anhydrides which are used in peptide coupling reactions. It serves as a dehydrating reagent for the conversion of primary amides to nitriles and an intermediate in the synthesis of pharmaceuticals and carbamates.

Preparation

Phenyl chloroformate is synthesized by the reaction of phenol with phosgene. Phenol was dissolved in chloroform, phosgene was introduced under cooling, and the absorbed phosgene was in an equal molar ratio to phenol, and equimolar N,N-dimethylaniline was added dropwise under stirring at 5-10 °C. Then add cold water to dilute, separate the oil layer, wash with dilute hydrochloric acid and water successively. After drying with anhydrous calcium chloride, chloroform is evaporated, and then distilled under reduced pressure to collect 74-75°C (1.73kPa) fraction, which is phenyl chloroformate. The yield is about 90%.

Application

Phenyl chloroformate is an important organic synthesis intermediate, which is widely used in chemical synthesis and can be used as polymer catalyst, plastic modifier, fiber treatment agent, and intermediate of medicine and pesticide.

General Description

Phenyl chloroformate appears as a colorless liquid with a strong odor. Toxic by ingestion, inhalation and skin absorption. Very irritating to skin and eyes. Used as a reagent for organic synthesis.

Air & Water Reactions

Emits fumes containing HCl in moist air. Decomposes in water to form HCl.

Reactivity Profile

Phenyl chloroformate is incompatible with strong oxidizing agents, alcohols, amines, alkali. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Health Hazard

TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

Safety Profile

Poison by inhalation. Moderately toxic by ingestion and skin contact. A corrosive sktn and eye irritant. See also ESTERS. When heated to decomposition it emits toxic fumes of Cl-.

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Phenyl chloroformate Suppliers

Shandong Hongyuan Chemical Technology Co., LTD
Tel
13561560789
Email
xinxiaoxiao2008@126.com
Country
China
ProdList
320
Advantage
58
SHANGHAI BANGCHENG CHEMICAL Co.,Ltd.
Tel
021-69106960 13701823733
Fax
021-69106780
Email
13701823733@163.com
Country
China
ProdList
4776
Advantage
60
Nanjing Vital Chemical Co., Ltd.
Tel
025-87193546 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
9030
Advantage
60
QUALITY CONTROL SOLUTIONS LTD.
Tel
15920483169
Email
ORDERS@QCSRM.COM
Country
China
ProdList
18735
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Beijing dtftchem Technology Co., Ltd.
Tel
010-60275820 13031183356
Fax
010-60270825
Email
elainezt@sina.com
Country
China
ProdList
1392
Advantage
62
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
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View Lastest Price from Phenyl chloroformate manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
Phenyl chloroformate 1885-14-9
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-06-28
Hebei Guanlang Biotechnology Co,.LTD
Product
Phenyl chloroformate 1885-14-9
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2022-12-12
Hebei Guanlang Biotechnology Co., Ltd.
Product
Phenyl chloroformate 1885-14-9
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-04-23

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