Propylene Carbonate as Solvent
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Propylene carbonate

Propylene Carbonate as Solvent
Product Name
Propylene carbonate
CAS No.
108-32-7
Chemical Name
Propylene carbonate
Synonyms
PC;1,2-PDC;ARCONATE;texacarpc;Texacar PC;Solvenon PC;arconate5000;1.2-Propylene;ene carbonate;ARCONATE(R) PC
CBNumber
CB8852744
Molecular Formula
C4H6O3
Formula Weight
102.09
MOL File
108-32-7.mol
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Propylene carbonate Property

Melting point:
-55 °C (lit.)
Boiling point:
240 °C (lit.)
Density 
1.204 g/mL at 25 °C (lit.)
vapor pressure 
0.13 mm Hg ( 20 °C)
refractive index 
n20/D 1.421(lit.)
Flash point:
270 °F
storage temp. 
Store below +30°C.
solubility 
240g/l
form 
Liquid
Specific Gravity
1.209 (20/4℃)
color 
Clear
Relative polarity
6
PH
7.0 (200g/l, H2O, 20℃)
explosive limit
1.8-14.3%(V)
Water Solubility 
240 g/L (20 ºC)
λmax
λ: 235 nm Amax: 1.00
λ: 280 nm Amax: 0.50
λ: 300 nm Amax: 0.30
λ: 350 nm Amax: 0.05
λ: 375-400 nm Amax: 0.01
BRN 
107913
Stability:
Stable. Incompatible with strong oxidizing agents, acids, bases, reducing agents. Protect from contact with moist air or water.
InChIKey
RUOJZAUFBMNUDX-UHFFFAOYSA-N
CAS DataBase Reference
108-32-7(CAS DataBase Reference)
NIST Chemistry Reference
Propylene carbonate(108-32-7)
EPA Substance Registry System
Propylene carbonate (108-32-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26-37/39
WGK Germany 
1
RTECS 
FF9650000
3-10
Autoignition Temperature
851 °F
TSCA 
Yes
HS Code 
29209010
Hazardous Substances Data
108-32-7(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 20000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.07051
Product name
Propylene carbonate
Purity
for synthesis
Packaging
100 mL
Price
$30.52
Updated
2021/03/22
Sigma-Aldrich
Product number
8.07051
Product name
Propylene carbonate
Purity
for synthesis
Packaging
1 L
Price
$62.9
Updated
2021/03/22
Sigma-Aldrich
Product number
310328
Product name
Propylene carbonate
Purity
anhydrous, 99.7%
Packaging
1l
Price
$119
Updated
2021/03/22
Sigma-Aldrich
Product number
1576504
Product name
Propylene carbonate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$399
Updated
2021/03/22
Sigma-Aldrich
Product number
8.07051
Product name
Propylene carbonate
Purity
for synthesis
Packaging
25 L
Price
$478
Updated
2021/03/22
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Propylene carbonate Chemical Properties,Usage,Production

Propylene Carbonate as Solvent

In the context of Green Chemistry, processes that minimise environmental impact are of great interest at both the industrial and academic levels, and the use of solvents that are innocuous to the environment is also a factor of great interest. Propylene carbonate maybe an appropriate choice. Not only it has a low evaporation rate, low toxicity, and VOC exemption, PC also has other benefits such as:

  • Improves lubricity
  • It is chemically stable
  • Co-firing in any atmosphere without oxidation
  • Excellent viscosity properties and green strength
  • Propylene Carbonate is one of the most eco-efficient alternatives for coating wires

Chemical Properties

colourless liquid

Chemical Properties

Propylene carbonate is a clear, colorless, mobile liquid, with a faint odor.

Uses

Pharmaceutic aid (gelling agent).

Uses

propylene carbonate is used in chemical reactions as a solvent, plasticizer, solubilizer, or dilutent.

Production Methods

Propylene carbonate may be prepared by the reaction of sodium bicarbonate with propylene chlorohydrin.

Preparation

To a stirred solution of 1,2- propanediol 957 (230 mg, 3.0 mmol) in toluene (8 mL) was added DPC (670 mg, 3.1 mmol). After stirring at 110 ℃ for 1.5 h, the reaction mixture was allowed to cool to room temperature, diluted with dichloromethane (40 mL), washed with brine (30 mL), dried over anhydrous MgSO4, and concentrated to dryness under reduced pressure. The crude product was distilled in vacuo in a kugelrohr apparatus to give 4-methyl-1,3-dioxolan-2-one 958 (254 mg) in 83% yield.

Pharmaceutical Applications

Propylene carbonate is used mainly as a solvent in oral and topical pharmaceutical formulations.
In topical applications, propylene carbonate has been used in combination with propylene glycol as a solvent for corticosteroids. The corticosteroid is dissolved in the solvent mixture to yield microdroplets that can then be dispersed in petrolatum.Propylene carbonate has been used as a dispensing solvent in topical preparations.
Propylene carbonate has also been used in hard gelatin capsules as a nonvolatile, stabilizing, liquid carrier. For formulations with a low dosage of active drug, a uniform drug content may be obtained by dissolving the drug in propylene carbonate and then spraying this solution on to a solid carrier such as compressible sugar; the sugar may then be filled into hard gelatin capsules
Propylene carbonate may additionally be used as a solvent, at room and elevated temperatures, for many cellulose-based polymers and plasticizers. Propylene carbonate is also used in cosmetics.

Safety

Propylene carbonate is used as a solvent in oral and topical pharmaceutical formulations, and is generally regarded as an essentially nontoxic and nonirritant material.
In animal studies, propylene carbonate was found to cause tissue necrosis after parenteral administration.
(mouse, oral): 20.7 g/kg
(mouse, SC): 15.8 g/kg
(rat, oral): 29 g/kg
(rat, SC): 11.1 g/kg

storage

Propylene carbonate and its aqueous solutions are stable but may degrade in the presence of acids or bases, or upon heating;
Store in a well-closed container in a cool, dry place.

Purification Methods

It is manufactured by reaction of 1,2-propylene oxide with CO2 in the presence of a catalyst (quaternary ammonium halide). Contaminants include propylene oxide, carbon dioxide, 1,2-and 1,3-propanediols, allyl alcohol and ethylene carbonate. It can be purified by percolation through molecular sieves (Linde 5A, dried at 350o for 14hours under a stream of argon), followed by distillation under a vacuum. [Jasinski & Kirkland Anal Chem 39 163 1967.] It can be stored over molecular sieves under an inert gas atmosphere. When purified in this way it contains less than 2ppm of water. Activated alumina and dried CaO have also been used as drying agents prior to fractional distillation under reduced pressure. It has been dried with 3A molecular sieves and distilled under nitrogen in the presence of p-toluenesulfonic acid, then redistilled and the middle fraction collected. [Beilstein 19 III/IV 1564, 19/4 V 21.]

Incompatibilities

Propylene carbonate hydrolyzes rapidly in the presence of strong acids and bases, forming mainly propylene oxide and carbon dioxide. Propylene carbonate can also react with primary and secondary amines to yield carbamates.

Regulatory Status

Included in the FDA Inactive Ingredients Database (topical ointments). Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

Propylene carbonate Preparation Products And Raw materials

Raw materials

Preparation Products

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Propylene carbonate Suppliers

SHANDONG SENJE CLEANTECHcO.,LTD.
Tel
0533-3883249-
Email
zzq528@163.com
Country
China
ProdList
1
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58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
021-20337333-801
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
24980
Advantage
65
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
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Tianmen Hengchang Chemical Co., Ltd
Tel
027-59322316- ;027-59322316-
Fax
027-59322316
Email
1208480077@qq.com;1178380066@qq.com
Country
China
ProdList
8894
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58
WUHAN JIXINYIBANG BIOTECHNOLOGY .,LTD
Tel
Email
2783694916@qq.com
Country
China
ProdList
2826
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58
Tianjin Zhongxin Chemtech Co., Ltd.
Tel
022-66880623;022-89880623
Fax
86(0)22-66880086
Email
sales@tjzxchem.com;sales@tjzxchem.com
Country
China
ProdList
617
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J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
future industrial shanghai co., ltd
Tel
400-0066-400;021-60496031
Fax
021-55660885
Email
sales@jonln.com;sales@jonln.com
Country
China
ProdList
1999
Advantage
65
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
84
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View Lastest Price from Propylene carbonate manufacturers

Wuhan Mulei New Material Technology Co. Ltd
Product
Propylene carbonate 108-32-7
Price
US $20.00/Kg/Drum
Min. Order
25Kg/Drum
Purity
99.99%
Supply Ability
1 ton per week
Release date
2021-04-02
Hebei Crovell Biotech Co Ltd
Product
P-Chlorobenzotrifluoride 108-32-7
Price
US $10.00/Kg/Drum
Min. Order
1KG
Purity
98%
Supply Ability
10 ton
Release date
2021-07-13
Hebei Dongdu Import and Export Co. LTD
Product
Propylene Carbonate (PC) 108-32-7
Price
US $1.30/Kg/Drum
Min. Order
20T
Purity
99.8%;99.7%;99.5%;99%
Supply Ability
1000tons/month
Release date
2020-12-10

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