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Chloromethyl isopropyl carbonate

Product Name
Chloromethyl isopropyl carbonate
CAS No.
35180-01-9
Chemical Name
Chloromethyl isopropyl carbonate
Synonyms
CMIC;Chloromethy Isopropyl carbonate;ALSTint-A08;Chloromethyl isoprop;Tenofovir Impurity 56;Tenofovir CMIC Impurity;Tenofovir Impurity 41 CRS;Tenofovir intermediate(CMIC);L-Propylchloromethylcarbonate;Chloromethyl isopropyl carbote
CBNumber
CB0223267
Molecular Formula
C5H9ClO3
Formula Weight
152.58
MOL File
35180-01-9.mol
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Chloromethyl isopropyl carbonate Property

Boiling point:
66 °C(Press: 16 Torr)
Density 
1.14
refractive index 
1.4110-1.4150
storage temp. 
Inert atmosphere,2-8°C
solubility 
Chloroform (Slightly), DMSO, Ethyl Acetate (Slightly)
form 
clear liquid
color 
Colorless to Almost colorless
Stability:
Moisture sensitive
InChI
InChI=1S/C5H9ClO3/c1-4(2)9-5(7)8-3-6/h4H,3H2,1-2H3
InChIKey
JHYNXXBAHWPABC-UHFFFAOYSA-N
SMILES
C(OC(C)C)(=O)OCCl
CAS DataBase Reference
35180-01-9(CAS DataBase Reference)
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Safety

Safety Statements 
24/25
RIDADR 
2924
HazardClass 
3/8
PackingGroup 
Ⅲ
HS Code 
29189900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1115705
Product name
Chloromethyl isopropyl carbonate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
100MG
Price
$1360
Updated
2024/03/01
TCI Chemical
Product number
C2626
Product name
Chloromethyl Isopropyl Carbonate
Purity
>98.0%(GC)
Packaging
25g
Price
$57
Updated
2024/03/01
TCI Chemical
Product number
C2626
Product name
Chloromethyl Isopropyl Carbonate
Purity
>98.0%(GC)
Packaging
100g
Price
$170
Updated
2024/03/01
Usbiological
Product number
268404
Product name
Chloromethyl isopropyl carbonate
Packaging
5g
Price
$360
Updated
2021/12/16
TRC
Product number
C369230
Product name
Chloromethyl Isopropyl Carbonate
Packaging
100g
Price
$470
Updated
2021/12/16
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Chloromethyl isopropyl carbonate Chemical Properties,Usage,Production

Chemical Properties

Clear Colourless Liquid

Uses

Chloromethyl Isopropyl Carbonate is an antiviral agent and a Tenofovir (T018500) intermediate. Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor used as an anti-HIV agent.

Synthesis

At 0-5°C, a photoinitiator is added, and dimethyl carbonate and chlorine are subjected to light reaction. The reaction is stopped, and the product is distilled and separated to obtain dimethyl monochlorocarbonate. At 70-100°C, a catalyst is added, and dimethyl monochlorocarbonate and isopropanol are added to a distillation tower capable of controlling the reflux ratio. Methanol is distilled and separated under normal pressure while reacting. After the reaction is completed, excess isopropanol is distilled off under reduced pressure, and finally chloromethyl isopropyl carbonate is distilled under reduced pressure.

Chloromethyl isopropyl carbonate Preparation Products And Raw materials

Raw materials

Preparation Products

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Chloromethyl isopropyl carbonate Suppliers

Americas 1 Belgium 2 Canada 2 China 377 Europe 1 Germany 1 India 49 Italy 1 Japan 2 United Kingdom 15 United States 32 Global 483
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
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View Lastest Price from Chloromethyl isopropyl carbonate manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
Chloromethyl isopropyl carbonate 35180-01-9
Price
US $30.00/kg
Min. Order
1kg
Purity
98
Supply Ability
2000kg
Release date
2024-05-14
Hebei Chuanghai Biotechnology Co,.LTD
Product
Chloromethyl Isopropyl Carbonate 35180-01-9
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-21
Shaanxi Dideu Medichem Co. Ltd
Product
Chloromethyl isopropyl carbonate 35180-01-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2024-08-09

35180-01-9, Chloromethyl isopropyl carbonateRelated Search:

Chloromethyl ethyl carbonate Diethyl (tosyloxy)methylphosphonate Tenofovir Fluorobenzene Sodium metabisulfite Quinolinic acid Chloromethyl chlorosulfate Chloromethyl isobutyrate (S)-Metolachlor N2-ISOBUTYRYL-2'-DEOXYGUANOSINE 2-Hydroxypropyl methacrylate Propylene carbonate Allyl methacrylate Isopropyl chloroformate Diisopropyl peroxydicarbonate Triphosgene rac-Tenofovir-d7 ChloroMethyl Propyl Carbonate

  • CMIC
  • CHLOROMETHYL ISOPROPYL CARBONATE
  • I-PROPYL CHLOROMETHYL CARBONATE
  • Chloromethyl (1-Methylethyl) Carbonate
  • Chloromethyl-2-propyl carbonate
  • L-Propylchloromethylcarbonate
  • Chloromethyl Isopropyl Carbonate (JMC-1)
  • Carbonic acid, chloromethyl 1-methylethyl ester
  • Chloromethy Isopropyl carbonate
  • Chloromethyl Isopropyl Carbonate (CMIC) ( CAS No. : )
  • Chloromethyl isopropyl carbonate ,99%
  • Chloromethyl isoprop
  • Carbonic Acid ChloroMethyl Isopropyl Ester
  • [(Isopropyloxycarbonyl)oxy]Methyl Chloride
  • chloroMethyl isopropyl carbonate (Sanyou)
  • ChloroMethyl Isopropyl Carbonate, 95+%
  • Chlorine Methyl isopropyl carbonate
  • Tenofovir intermediate(CMIC)
  • Chloromethyl isopropyl carbonate, >=99.5%
  • carbonic acid chloromethyl ester isopropyl ester
  • Chloromethyl isopropyl carbonate(CMIC)
  • Chioromethyl isopropyl carbonate
  • Chloromethyl isopropyl carbote
  • Tenofovir Disoproxil Fumarate impurity S
  • ALSTint-A08
  • Tenofovir Impurity 56
  • Chloromethyl Isopropyl Carbonate &gt
  • Tenofovir CMIC Impurity
  • TIANFU-CHEM - Chloromethyl isopropyl carbonate
  • Chloromethyl isopropyl carbonate [Tenofovir Disoproxil Fumarate Impurity
  • Tenofovir disoproxil Impurity 96
  • Tenofovir Impurity 41 CRS
  • 35180-01-9
  • 5180-1-9
  • Miscellaneous Reagents
  • Pharmaceutical Intermediates
  • bc0001