Cyclopropylamine
- Product Name
- Cyclopropylamine
- CAS No.
- 765-30-0
- Chemical Name
- Cyclopropylamine
- Synonyms
- Cyclopropanamine;AMINOCYCLOPROPANE;AURORA KA-2551;Cylopropylamine;Cydopropylamine;Cyloprolylamine;CYCLOPROPYLAMINE;Ring propylaMine;AKOS BBS-00003593;AMINOTRIMETHYLENE
- CBNumber
- CB1782699
- Molecular Formula
- C3H7N
- Formula Weight
- 57.09
- MOL File
- 765-30-0.mol
Cyclopropylamine Property
- Melting point:
- -50 °C
- Boiling point:
- 49-50 °C (lit.)
- Density
- 0.824 g/mL at 25 °C (lit.)
- vapor pressure
- 4.67 psi ( 20 °C)
- refractive index
- n20/D 1.420(lit.)
- Flash point:
- −14 °F
- storage temp.
- Store below +30°C.
- solubility
- Chloroform, Ethyl Acetate (Sparingly), Methanol (Slightly)
- form
- Volatile Liquid
- pka
- pK1:9.10(+1) (25°C)
- color
- Clear colorless
- Specific Gravity
- 0.824
- Water Solubility
- Miscible with water, ethanol,ether and chloroform.
- Sensitive
- Lachrymatory
- BRN
- 741858
- Stability:
- Volatile
- InChIKey
- HTJDQJBWANPRPF-UHFFFAOYSA-N
- LogP
- 0.070
- CAS DataBase Reference
- 765-30-0(CAS DataBase Reference)
- NIST Chemistry Reference
- Cyclopropylamine(765-30-0)
- EPA Substance Registry System
- Cyclopropanamine (765-30-0)
Safety
- Hazard Codes
- F,C,Xi
- Risk Statements
- 11-22-34-36/37
- Safety Statements
- 16-26-36/37/39-45-33-7/9
- RIDADR
- UN 2733 3/PG 2
- WGK Germany
- 2
- RTECS
- GZ0685500
- Autoignition Temperature
- 527 °F
- Hazard Note
- Extremely Flammable/Harmful/Corrosive/Lachrymatory
- TSCA
- T
- HazardClass
- 3
- PackingGroup
- II
- HS Code
- 29213099
- Toxicity
- LD50 orally in Rabbit: 445 mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 8.18017
- Product name
- Cyclopropylamine
- Purity
- for synthesis
- Packaging
- 10ml
- Price
- $38.5
- Updated
- 2024/03/01
- Product number
- 8.18017
- Product name
- Cyclopropylamine
- Purity
- for synthesis
- Packaging
- 100mL
- Price
- $290
- Updated
- 2024/03/01
- Product number
- 125504
- Product name
- Cyclopropylamine
- Purity
- 98%
- Packaging
- 10g
- Price
- $44.6
- Updated
- 2024/03/01
- Product number
- 125504
- Product name
- Cyclopropylamine
- Purity
- 98%
- Packaging
- 25g
- Price
- $89.7
- Updated
- 2024/03/01
- Product number
- C0981
- Product name
- Cyclopropylamine
- Purity
- >95.0%(GC)(T)
- Packaging
- 5mL
- Price
- $20
- Updated
- 2024/03/01
Cyclopropylamine Chemical Properties,Usage,Production
Chemical Properties
Cyclopropylamine is a colorless and transparent flammable liquid with volatility and ammonia odor. It is miscible with water, methanol, ethanol, benzene, toluene and other solvents.
Uses
Cyclopropylamine is used in the preparation of N-[4-(4-fluoro)phenyl-2-aminothiazol-5-yl]pyrimidin-2-yl-alkylamine derivatives. It is also used to prepare Pt(CPA)2(bismethylthiomethylenepropanedioate) and Pt(CPA)2(bisethylthiomethylenepropanedioate) complexes.
Definition
ChEBI: Cyclopropylamine is a primary aliphatic amine that consists of cyclopropane bearing a single amino substituent. It has a role as a mouse metabolite.
Application
Cyclopropylamine is mainly used in organic synthesis, pharmaceutical synthesis intermediates, and can be used in the synthesis of new antibacterial drugs ciprofloxacin products, such as the synthesis of ciprofloxacin, enrofloxacin, spafloxacin and other drugs. In addition, cyclopropylamine is also an important intermediate for the synthesis of pesticides, plant protection agents and herbicides, such as 2-chloro-4-6-cyclopropyl-s-triazine, cyprochlor, cyproterazine, cyprocyanine and other cyclopropanes class of pesticides.
Preparation
Cyclopropylamine is synthesized from 1,3-propanediol by bromination, cyanation, cyclization, amidation, and Hoffmann rearrangement. It is also synthesized with γ-butyrolactone and isopropanol by five steps of ring-opening esterification, cyclization, hydrolysis, acylation and Hofmann degradation.
Biochem/physiol Actions
Cyclopropylamine inactivates cytochrome P450 enzymes by a mechanism involving initial one-electron oxidation at nitrogen followed by scission of the cyclopropane ring leading to covalent modification of the enzyme. It is a mechanism-based inhibitor of quinoprotein methylamine dehydrogenase from Paracoccus denitrificans.
Purification Methods
It has been isolated as the benzamide m 100.6-101.0o (from aqueous EtOH). It forms a picrate m 149o (from EtOH/pet ether) from which the free base can be recovered using a basic ion-exchange resin and can then be distilled through a Todd column (p 11) using an automatic still head which only collects products boiling below 51o/atm. Polymeric materials if present will boil above this temperature. The hydrochloride has m 85-86o [Roberts & Chambers J Am Chem Soc 73 5030 1951, Jones J Org Chem 9 484 1944, Emmons J Am Chem Soc 79 6522 1957]. [Beilstein 12 IV 3.]
Cyclopropylamine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Cyclopropylamine manufacturers
- Product
- Cyclopropylamine 765-30-0
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 10 ton
- Release date
- 2024-08-23
- Product
- Cyclopropylamine 765-30-0
- Price
- US $10.00-100.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100 tons
- Release date
- 2024-03-12
- Product
- Cyclopropylamine 765-30-0
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99%
- Supply Ability
- 1-10000kgs
- Release date
- 2023-09-11