1-(Cbz-amino)cyclopropanecarboxylic acid
- Product Name
- 1-(Cbz-amino)cyclopropanecarboxylic acid
- CAS No.
- 84677-06-5
- Chemical Name
- 1-(Cbz-amino)cyclopropanecarboxylic acid
- Synonyms
- Z-ACPC-OH;Z-AC3C-OH;Cbz-ACPC-OH;1-(Z-amino)cycL;1-(z-amino)cyclopropanecarboxylic acid;Z-1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID;1-(Cbz-amino)cyclopropanecarboxylic acid;N-Cbz-1-aMinocyclopropanecarboxylic acid;CBZ-1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID;1-(N-CBZ-AMINO)CYCLO-PROPANECARBOXYLIC ACID
- CBNumber
- CB1349236
- Molecular Formula
- C12H13NO4
- Formula Weight
- 235.24
- MOL File
- 84677-06-5.mol
1-(Cbz-amino)cyclopropanecarboxylic acid Property
- Melting point:
- 157.0 to 161.0 °C
- Boiling point:
- 449.0±34.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 4.02±0.20(Predicted)
- color
- White to Almost white
- CAS DataBase Reference
- 84677-06-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C7047
- Product name
- 1-(Z-amino)cyclopropanecarboxylic acid
- Packaging
- 500mg
- Price
- $430
- Updated
- 2025/07/31
- Product number
- C2680
- Product name
- 1-(Carbobenzoxyamino)cyclopropanecarboxylic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $32
- Updated
- 2025/07/31
- Product number
- C2680
- Product name
- 1-(Carbobenzoxyamino)cyclopropanecarboxylic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $129
- Updated
- 2025/07/31
- Product number
- B130013
- Product name
- 1-(Benzyloxycarbonylamino)cyclopropyl-1-carboxylicAcid
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 261303
- Product name
- Z-1-aminocyclopropane-1-carboxylic acid
- Packaging
- 2g
- Price
- $345
- Updated
- 2021/12/16
1-(Cbz-amino)cyclopropanecarboxylic acid Chemical Properties,Usage,Production
Chemical Properties
White powder
Uses
1-(Benzyloxycarbonylamino)cyclopropyl-1-carboxylic Acid is a useful intermediate used in the preparation of the analogs of vasopressins and other peptide derivatives.
Synthesis
13139-17-8
22059-21-8
84677-06-5
Step A: Synthesis of intermediate VI A tetrahydrofuran (THF, 500 mL) solution of benzyl 2,5-dioxopyrrolidin-1-yl carbonate (83 g, 334 mmol) was added slowly and dropwise to an aqueous (500 mL) solution of 1-aminocyclopropanecarboxylic acid (25 g, 247 mmol). A solution of sodium bicarbonate (91 g, 1088 mmol) in water (500 mL) was added dropwise to the reaction mixture under cooling in an ice bath. After the dropwise addition, the reaction system was slowly warmed to room temperature and the reaction was continued with stirring for 16 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was resuspended in dichloromethane (200 mL) and extracted with water (500 mL). The aqueous phase was acidified by acetic acid and the precipitated white solid was collected by filtration to afford 1-((benzyloxy)carbonyl)amino)cyclopropanecarboxylic acid (53 g, 171 mmol, 69.2% yield). The crude product can be directly used in the next step of the reaction.LC/MS analysis result: m/z calculated value 235.1, measured value 258.0 ([M+Na]+).
References
[1] Synlett, 2004, # 14, p. 2489 - 2492
[2] Patent: WO2013/20245, 2013, A1. Location in patent: Paragraph 00105
[3] Patent: WO2015/95227, 2015, A2. Location in patent: Page/Page column 220; 221
1-(Cbz-amino)cyclopropanecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(Cbz-amino)cyclopropanecarboxylic acid manufacturers
- Product
- 1-(Benzyloxycarbonylamino)cyclopropyl-1-carboxylic acid 84677-06-5
- Price
- US $1.10-9.90/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-08-18
- Product
- 1-(Cbz-amino)cyclopropanecarboxylic acid 84677-06-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 1-(Cbz-amino)cyclopropanecarboxylic acid 84677-06-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-06-11